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Cellular Response of Therapeutic Nanoparticles

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Book cover Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

Abstract

Nanoparticles (NPs) are being extensively used in the field of nanomedicines. Different types of NPs are administered into the body by various routes. NPs come in contact with cells inside the body. Cellular response of NPs is affected by size, shape, surface chemistry, and cellular uptake pathways of NPs. In addition to this, type of cells, various cell lines, and growth media are also found to affect the cellular response of NPs. NPs induce diverse cellular responses like apoptosis, necrosis, and reactive oxygen species (ROS) production. NPs also form a protein corona inside the biological media which may alter their identity and behaviour as compared to bare NPs. In this chapter, we have made an attempt to throw light on cellular uptake pathways of NPs, monitoring of endocytic pathways followed by NPs, factors affecting cellular responses of therapeutic NPs, and protein corona formation, characterisation and its implications on fate of NPs.

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Acknowledgments

We are grateful to Director, IHBT for critical and valuable suggestions. Financial assistance from Council of Scientific and Industrial Research, Government of India is genuinely acknowledged.

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Authors and Affiliations

  1. Department of Biotechnology, Council of Scientific and Industrial Research-Institute of Himalayan Bioresource Technology, Palampur, 176061, Himachal Pradesh, India

    Avnesh Kumari, Rubbel Singla, Anika Guliani, Amitabha Acharya & Sudesh Kumar Yadav

  2. Academy of Scientific and Innovative Research, New Delhi, India

    Avnesh Kumari, Rubbel Singla, Anika Guliani, Amitabha Acharya & Sudesh Kumar Yadav

  3. Department of Biotechnology, Center of Innovative and Applied Bioprocessing (CIAB), Mohali, 160071, Punjab, India

    Sudesh Kumar Yadav

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  1. Avnesh Kumari
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  2. Rubbel Singla
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  3. Anika Guliani
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  4. Amitabha Acharya
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  5. Sudesh Kumar Yadav
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Correspondence to Amitabha Acharya or Sudesh Kumar Yadav .

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  1. Department of Biotechnology, CSIR-IHBT, Palampur, Himachal Pradesh, India

    Sudesh Kumar Yadav

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Kumari, A., Singla, R., Guliani, A., Acharya, A., Yadav, S.K. (2016). Cellular Response of Therapeutic Nanoparticles. In: Yadav, S. (eds) Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration. Springer, Singapore. https://doi.org/10.1007/978-981-10-0818-4_7

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