Abstract
It is known that cells acquire a transient resistance to heat when cells are treated with a pre-mild heat. This phenomenon is so-called thermo-tolerance. Thermo-tolerance restricts the effectiveness of hyperthermia and combined therapy of hyperthermia and radio-therapy. Heat shock proteins (HSPs) are reported to play important roles in thermo-tolerance of cells. However, the details of the molecular mechanism in which HSPs restore or repair proteins are still unknown. This chapter proposes possible molecular mechanisms which might play a role in heat sensitivity and thermo-tolerance.
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© 2016 Springer Science+Business Media Singapore
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Ohnishi, K. (2016). Thermo-Tolerance. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_7
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DOI: https://doi.org/10.1007/978-981-10-0719-4_7
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