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Hyperthermic Oncology from Bench to Bedside pp 329–340Cite as

Effects of Fever-Range Hyperthermia on T Cell-Mediated Immunity: Possible Combination of Hyperthermia and T Cell-Based Cancer Immunotherapy

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Abstract

Elevated body temperature has been thought to play an important role in the regulation of immune responses, and accumulating evidence in thermal medicine indicates that hyperthermia could be a useful combination therapy to enhance the efficacy of cancer immunotherapy. However, the intrinsic effects of elevated body temperature on the immune system are poorly understood, particularly in humans. Future clinical studies are expected to elucidate the practical utility of hyperthermia, and in particular fever-range whole-body hyperthermia in combination with T-cell and/or DC-based cancer immune cell therapy.

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Authors and Affiliations

  1. Bio-Thera Clinic, 5-6-12 Shinjuku, Shinjuku-ku, Tokyo, 1600022, Japan

    Keishi Tanigawa, Yusuke Ito & Yasunobu Kobayashi

Authors
  1. Keishi Tanigawa
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  2. Yusuke Ito
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  3. Yasunobu Kobayashi
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Corresponding author

Correspondence to Keishi Tanigawa .

Editor information

Editors and Affiliations

  1. Kokura Lab, Health and Medical Sciences, Kyoto Gakuen University, Kyoto, Kyoto, Japan

    Satoshi Kokura

  2. Department of Inflammation and Immunolog, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan

    Toshikazu Yoshikawa

  3. Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan

    Takeo Ohnishi

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© 2016 Springer Science+Business Media Singapore

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Tanigawa, K., Ito, Y., Kobayashi, Y. (2016). Effects of Fever-Range Hyperthermia on T Cell-Mediated Immunity: Possible Combination of Hyperthermia and T Cell-Based Cancer Immunotherapy. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_31

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  • DOI: https://doi.org/10.1007/978-981-10-0719-4_31

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-0717-0

  • Online ISBN: 978-981-10-0719-4

  • eBook Packages: MedicineMedicine (R0)

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