Abstract
We treated 2322 patients with advanced or recurrent cancer using immunotherapy or hyperthermia (HT) (between July 2005 and March 2015). HT was used in 2235 cancer patients, cytokine-activated T cells (CAT) in 1256 patients, and dendritic cells (DC) in 1447 patients. Response to therapy was evaluated in 2217 patients. Clinical benefit case (complete response (CR), partial response (PR) or 6-month stable disease (SD)) was noted in 350 patients, including 35 who showed CR. The rate of beneficial effects from DC increased from 7.1 to 19.1 % of patients with the addition of HT. The rate of beneficial effects from DC + CAT increased from 15.4 to 21.6 % of patients who also received HT. Maximal response rate (21.6 %) was thus noted in patients who received combination therapy comprising CAT + DC + HT. DC with HT had beneficial effects on multiple metastases observed in multiple important solid organs in breast cancer cases.
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© 2016 Springer Science+Business Media Singapore
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Takeda, T., Takeda, T. (2016). Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_30
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DOI: https://doi.org/10.1007/978-981-10-0719-4_30
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