Abstract
We treated 2322 patients with advanced or recurrent cancer using immunotherapy or hyperthermia (HT) (between July 2005 and March 2015). HT was used in 2235 cancer patients, cytokine-activated T cells (CAT) in 1256 patients, and dendritic cells (DC) in 1447 patients. Response to therapy was evaluated in 2217 patients. Clinical benefit case (complete response (CR), partial response (PR) or 6-month stable disease (SD)) was noted in 350 patients, including 35 who showed CR. The rate of beneficial effects from DC increased from 7.1 to 19.1 % of patients with the addition of HT. The rate of beneficial effects from DC + CAT increased from 15.4 to 21.6 % of patients who also received HT. Maximal response rate (21.6 %) was thus noted in patients who received combination therapy comprising CAT + DC + HT. DC with HT had beneficial effects on multiple metastases observed in multiple important solid organs in breast cancer cases.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Ito A, Shinkai M, Honda H, et al. Augmentation of MHC class I antigen presentation via heat shock ptotein expression by hyperthermia. Cancer Immunol Immunother. 2001;50:515–22.
Takahashi T, Mitsuhashi N, Sakurai H, et al. Modification of tumor-asociated antigen expression on human lung cancer cells by hyperthermia and cytokine. Anticancer Res. 1995;15:2601–6.
Ostberg JR, Kabingu E, Repasky EA. Thermal regulation of dendritic cell activation and migration from skin explants. Int J Hyperthermia. 2003;19:520–33.
Takeda T, Takahashi T, Yamamoto I, et al. Hyperthermia enhances immunotherapy in cancer patients: clinical and experimental analyses. Thermal Med. 2012;28:11–6.
Takeda T, Kobayashi T, Monden T, et al. The effect of local immunotherapy for breast cancer using a mixture of OK-432 and fibrinogen supplemented with activated macrophages. Biotherapy. 1994;7:47–54.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Science+Business Media Singapore
About this chapter
Cite this chapter
Takeda, T., Takeda, T. (2016). Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_30
Download citation
DOI: https://doi.org/10.1007/978-981-10-0719-4_30
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-0717-0
Online ISBN: 978-981-10-0719-4
eBook Packages: MedicineMedicine (R0)