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Combination by Hyperthermia and Radiation (and Chemotherapy): Lung Cancer

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Hyperthermic Oncology from Bench to Bedside

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Abstract

In this chapter, the clinical results of radiotherapy or chemoradiotherapy with hyperthermia for the treatment of lung cancer were reviewed. Especially for the patients with superior sulcus tumors or lung cancer with chest wall invasion, the intra-tumor temperature could be elevated to therapeutic levels by the 8-MHz RF capacitive heating device. The correlations between the clinical outcomes and thermal parameters were observed. A randomized trial demonstrated that an adding of hyperthermia to radiotherapy showed a significant improvement in the local tumor control rate in patients with non-small cell lung cancer.

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References

  1. van der Zee J. Heating the patient: a promising approach? Ann Oncol. 2002;13(8):1173–84.

    Article  PubMed  Google Scholar 

  2. Jones EL, Samulski TV, Leonard RP, Dewhirst MW. Hyperthermia. In: Principles and practice of radiation oncology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2003.

    Google Scholar 

  3. Hiraoka M, Masunaga S, Nishimura Y, Nagata Y, Jo S, Akuta K, et al. Regional hyperthermia combined with radiotherapy in the treatment of lung cancers. Int J Radiat Oncol Biol Phys. 1992;22(5):1009–14.

    Article  CAS  PubMed  Google Scholar 

  4. Karasawa K, Muta N, Nakagawa K, Hasezawa K, Terahara A, Onogi Y, et al. Thermoradiotherapy in the treatment of locally advanced nonsmall cell lung cancer. Int J Radiat Oncol Biol Phys. 1994;30(5):1171–7.

    Article  CAS  PubMed  Google Scholar 

  5. Sakurai H, Hayakawa K, Mitsuhashi N, Tamaki Y, Nakayama Y, Kurosaki H, et al. Effect of hyperthermia combined with external radiation therapy in primary non-small cell lung cancer with direct bony invasion. Int J Hyperthermia. 2002;18(5):472–83. doi:10.1080/02656730210146917.

    Article  CAS  PubMed  Google Scholar 

  6. Ohguri T, Imada H, Yahara K, Morioka T, Nakano K, Terashima H, et al. Radiotherapy with 8-MHz radiofrequency-capacitive regional hyperthermia for stage III non-small-cell lung cancer: the radiofrequency-output power correlates with the intraesophageal temperature and clinical outcomes. Int J Radiat Oncol Biol Phys. 2009;73(1):128–35. doi:S0360-3016(08)00648-2 [pii] 10.1016/j.ijrobp.2008.03.059.

    Article  PubMed  Google Scholar 

  7. Song CW, Rhee JG, Lee CK, Levitt SH. Capacitive heating of phantom and human tumors with an 8 MHz radiofrequency applicator (Thermotron RF-8). Int J Radiat Oncol Biol Phys. 1986;12(3):365–72. doi:0360-3016(86)90352-4 [pii].

    Article  CAS  PubMed  Google Scholar 

  8. Abe M, Hiraoka M, Takahashi M, Egawa S, Matsuda C, Onoyama Y, et al. Multi-institutional studies on hyperthermia using an 8-MHz radiofrequency capacitive heating device (Thermotron RF-8) in combination with radiation for cancer therapy. Cancer. 1986;58(8):1589–95.

    Article  CAS  PubMed  Google Scholar 

  9. Imada T, Nomoto S, Tomimatsu A, Kosaka K, Kusano S, Ostapenk VV, et al. Importance of patient positioning in hyperthermia for deep-seated intrathoracic tumors using an 8 MHz RF capacitive heating device. Jpn J Hyperthermic Oncol. 1999;15(1):15–9.

    Google Scholar 

  10. Ohguri T, Yahara K, Murakami M, Imada H, Terashima H, Korogi Y. Current status and future directions of hyperthermia at the University of Occupational and Environmental Health. Thermal Med. 2010;26(3):87–96.

    Article  Google Scholar 

  11. Tomimatsu A, Imada H, Kosaka K, Nomoto S, Kusano S, Ostapenko VV. Refinement of circulating liquid of overlay bolus in hyperthermia using an 8 MHz RF capacitive heating device. Jpn J Hyperthermic Oncol. 1999;15(2):71–7.

    Google Scholar 

  12. Ohguri T, Imada H, Yahara K, Kakeda S, Tomimatsu A, Kato F, et al. Effect of 8-MHz radiofrequency-capacitive regional hyperthermia with strong superficial cooling for unresectable or recurrent colorectal cancer. Int J Hyperthermia. 2004;20(5):465–75. doi:10.1080/02656730310001657729. H74GQRD0GEFG59ME [pii].

    Article  CAS  PubMed  Google Scholar 

  13. Tomimatsu A, Imada H, Kosaka K, Nomoto S, Kusano S, Ostapenko VV, et al. Advantage of an external cooling unit in deep hyperthermia using an 8 MHz RF capacitive heating device. Jpn J Hyperthermic Oncol. 1999;15(2):65–70.

    Google Scholar 

  14. Kroeze H, van de Kamer JB, de Leeuw AA, Kikuchi M, Lagendijk JJ. Treatment planning for capacitive regional hyperthermia. Int J Hyperthermia. 2003;19(1):58–73. doi:905C1MH2DYR4XEF4 [pii].

    Article  CAS  PubMed  Google Scholar 

  15. Ohguri T, Yahara K, Moon SD, Yamaguchi S, Imada H, Terashima H, et al. Deep regional hyperthermia for the whole thoracic region using 8 MHz radiofrequency-capacitive heating device: relationship between the radiofrequency-output power and the intra-oesophageal temperature and predictive factors for a good heating in 59 patients. Int J Hyperthermia. 2011;27(1):20–6. doi:10.3109/02656736.2010.500644.

    Article  PubMed  Google Scholar 

  16. Feldmann HJ, Seegenschmiedt MH, Molls M. Hyperthermia--its actual role in radiation oncology. Part III: clinical rationale and results in deep seated tumors. Strahlenther Onkol. 1995;171(5):251–64.

    CAS  PubMed  Google Scholar 

  17. van der Zee J, Vujaskovic Z, Kondo M, Sugahara T. The Kadota Fund International Forum 2004--clinical group consensus. Int J Hyperthermia. 2008;24(2):111–22. doi:790655589 [pii] 10.1080/02656730801895058.

    Article  PubMed  PubMed Central  Google Scholar 

  18. van der Zee J, Gonzalez Gonzalez D, van Rhoon GC, van Dijk JD, van Putten WL, Hart AA. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group. Lancet. 2000;355(9210):1119–25. doi:S0140673600020596 [pii].

    Article  PubMed  Google Scholar 

  19. Moon SD, Ohguri T, Imada H, Yahara K, Yamaguchi S, Hanagiri T, et al. Definitive radiotherapy plus regional hyperthermia with or without chemotherapy for superior sulcus tumors: a 20-year, single center experience. Lung Cancer. 2011;71(3):338–43. doi:S0169-5002(10)00276-X [pii] 10.1016/j.lungcan.2010.06.007.

    Article  PubMed  Google Scholar 

  20. Mitsumori M, Zeng ZF, Oliynychenko P, Park JH, Choi IB, Tatsuzaki H, et al. Regional hyperthermia combined with radiotherapy for locally advanced non-small cell lung cancers: a multi-institutional prospective randomized trial of the International Atomic Energy Agency. Int J Clin Oncol. 2007;12(3):192–8. doi:10.1007/s10147-006-0647-5.

    Article  PubMed  Google Scholar 

  21. Fournel P, Robinet G, Thomas P, Souquet PJ, Lena H, Vergnenegre A, et al. Randomized phase III trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer: Groupe Lyon-Saint-Etienne d’Oncologie Thoracique-Groupe Francais de Pneumo-Cancerologie NPC 95-01 Study. J Clin Oncol. 2005;23(25):5910–17. doi:JCO.2005.03.070 [pii] 10.1200/JCO.2005.03.070.

    Article  CAS  PubMed  Google Scholar 

  22. Vernon CC, Hand JW, Field SB, Machin D, Whaley JB, van der Zee J, et al. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. Int J Radiat Oncol Biol Phys. 1996;35(4):731–44. doi:036030169600154X [pii].

    Article  CAS  PubMed  Google Scholar 

  23. Juffermans JH, Hanssens PE, van Putten WL, van Rhoon GC, van Der Zee J. Reirradiation and hyperthermia in rectal carcinoma: a retrospective study on palliative effect. Cancer. 2003;98(8):1759–66. doi:10.1002/cncr.11719.

    Article  PubMed  Google Scholar 

  24. Milani V, Pazos M, Issels RD, Buecklein V, Rahman S, Tschoep K, et al. Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer. Strahlenther Onkol. 2008;184(3):163–8. doi:10.1007/s00066-008-1731-8.

    Article  PubMed  Google Scholar 

  25. Ohguri T, Imada H, Yahara K, Moon SD, Yamaguchi S, Yatera K, et al. Re-irradiation plus regional hyperthermia for recurrent non-small cell lung cancer: a potential modality for inducing long-term survival in selected patients. Lung Cancer. 2012;77(1):140–5. doi:S0169-5002(12)00107-9 [pii] 10.1016/j.lungcan.2012.02.018.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University of Occupational and Environmental Health, 1‑1 Iseigaoka, Yahatanishi‑ku, Kitakyushu, 807-8555, Japan

    Takayuki Ohguri

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  1. Takayuki Ohguri
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Correspondence to Takayuki Ohguri .

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Editors and Affiliations

  1. Kokura Lab, Health and Medical Sciences, Kyoto Gakuen University, Kyoto, Kyoto, Japan

    Satoshi Kokura

  2. Department of Inflammation and Immunolog, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan

    Toshikazu Yoshikawa

  3. Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan

    Takeo Ohnishi

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Ohguri, T. (2016). Combination by Hyperthermia and Radiation (and Chemotherapy): Lung Cancer. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_17

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  • DOI: https://doi.org/10.1007/978-981-10-0719-4_17

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-0717-0

  • Online ISBN: 978-981-10-0719-4

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