Abstract
Solid tumors have a more acidic and hypoxic microenvironment than normal tissue. This unfavorable microenvironment results from an imbalance in the oxygen supply and demand of the tumor tissue. To overcome hypoxia, the tumor induces a new vascular supply. This new vasculature, however, is inefficient and chaotic, resulting in preserving the factors that stimulated the neovascularization. This review focuses on these processes and particularly on angiogenesis, tumor vascular morphology, hypoxia, pH, and the metabolic-vascular events induced or following tumor tissue heating. The various mechanisms that either modulate tumor microenvironments or blood perfusion during hyperthermia are described, providing also the many clinical modalities that may enhance or sensitize cancer cells to heat.
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Masunaga, Si. (2016). Tumor Microenvironment and Hyperthermia. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_14
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DOI: https://doi.org/10.1007/978-981-10-0719-4_14
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