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Allergy and Immunotoxicology in Occupational Health pp 115–128Cite as

Combined Effect on Immune and Nervous System of Aluminum Nanoparticles

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Abstract

Aluminum is believed to be a neurotoxicant for a lot of years and thought to be related with Alzheimer’s disease. In recent decades, aluminum nanoparticles have been utilized widely in many fields, and their potential adverse effect on health drew great concern. Al2O3 nanoparticles (ANPs) can be inhaled more deeply into the respiratory system, and translocated into the bloodstream to induce immunotoxicity and into the central nervous system to induce neurotoxicity, of which the possible mechanisms are summarized in this chapter. ANPs may induce pneumocyte apoptosis by triggering oxidative stress and inhibit or activate activity of cytokines, and the immunotoxicity induced by nanoalumina (Nano-Al) particles was higher than that of macro-sized alumina particles. Besides though blood compartment by which ANPs damage the blood-brain barrier, ANPs may enter into the central nervous system through the olfactory nerve. ANPs impair behavioral performance of model organisms and rodents. ANPs may induce neural cell death by triggering apoptosis, necrosis, and autophagy, complicate cell signal transmission pathways, and promote Aβ deposit and degeneration.

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Author information

Authors and Affiliations

  1. Occupational Health Department, Public Health School, Shanxi Medical University, Shanxy, Taiyuan, 030001, China

    Qiao Niu

  2. Shanxi medical University, Taiyuan, 030001, China

    Qinli Zhang

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  1. Qiao Niu
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  2. Qinli Zhang
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Correspondence to Qiao Niu .

Editor information

Editors and Affiliations

  1. Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan

    Takemi Otsuki

  2. Immuntotoxicology and Allergy Unit & Occupational Biorepository, Center of Excellence on Aging and Translational Medicine (CeSI-MeT), “G. D’Annunzio” University Foundation, Chieti, Italy

    Claudia Petrarca

  3. Immuntotoxicology and Allergy Unit & Occupational Biorepository, Center of Excellence on Aging and Translational Medicine (CeSI-MeT), “G. D’Annunzio” University Foundation, Chieti, Italy

    Mario Di Gioacchino

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Niu, Q., Zhang, Q. (2017). Combined Effect on Immune and Nervous System of Aluminum Nanoparticles. In: Otsuki, T., Petrarca, C., Di Gioacchino, M. (eds) Allergy and Immunotoxicology in Occupational Health. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-10-0351-6_9

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  • DOI: https://doi.org/10.1007/978-981-10-0351-6_9

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  • Publisher Name: Springer, Singapore

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  • Online ISBN: 978-981-10-0351-6

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