Abstract
There were some studies both in vivo and in vitro, which showed some toxic effects of Cu-NPs. This study focused on the effect of these materials on rats’ hippocampal synaptic plasticity and spatial cognition, and the possible mechanism. In this research, 16 adult male Wistar rats were randomly divided into two groups: control group and Cu-NPs group. After intranasal application of Cu-NPs (3mg/kg) for two weeks, Morris water maze (MWM) was applied to evaluate the spatial learning and memory ability followed by long-term potentiation (LTP) to assess the hippocampal synaptic plasticity. The results showed that when compared with the control group, both results of MWM and LTP were impaired in Cu-NPs group. The histology analysis showed an abnormal morphology of hippocampal neurons in rats of Cu-NPs group. The content of reactive oxygen species (ROS) increased in hippocampus homogenate in Cu-NPs group, while the glutathione peroxidase (GSH-Px) level was reduced in this group. All the results above showed that Cu-NPs can cause damage to rats’ hippocampal synaptic plasticity and spatial cognition. The excessive ROS and decrease in GSH-Px levels can cause severe oxidative stress, which may account for the influence by Cu-NPs.
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This work was partly supported by the National Natural Science Foundation of China (31271074).
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Liu, Y., Guan, W., Liu, J., Yang, Z. (2016). The Impact of Nasal Copper Nanoparticle Exposure on Rats’ Synaptic Plasticity and Spatial Cognition. In: Wang, R., Pan, X. (eds) Advances in Cognitive Neurodynamics (V). Advances in Cognitive Neurodynamics. Springer, Singapore. https://doi.org/10.1007/978-981-10-0207-6_35
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DOI: https://doi.org/10.1007/978-981-10-0207-6_35
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