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Functional Nanoparticles for Molecular Imaging-Guided Gene Delivery and Therapy

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Advances in Nanotheranostics II

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 7))

Abstract

The inefficient delivery of genes to target tissues and the inability to monitor delivery of genes and therapeutic responses at both cellular and tissue level hinder the success of gene therapy. Fortunately, molecular imaging strategy provides a vital role in assisting gene therapy in a noninvasive and spatiotemporal manner. To better optimize the effectiveness of gene therapy, numerous functional nanoparticles have been developed to achieve this goal while visualizing the delivery process. This chapter provides an overview of various functionalized nanoparticles with unique physiochemical properties for molecular imaging-guided gene therapy.

The original version of this chapter was revised: The name and affiliation of the author Yu Zhang was corrected. The erratum to this chapter is available at: http://dx.doi.org/10.1007/978-981-10-0063-8_11

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-981-10-0063-8_11

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Acknowledgments

This work was supported by the College of Engineering and Mathematical Sciences at the University of Vermont, the Major State Basic Research Development Program of China (973 Program) (Grant Nos. 2014CB744503 and 2013CB733802), the National Natural Science Foundation of China (NSFC) (Grant Nos. 81422023, 81101101, 81371596, and 51273165), the Key Project of Chinese Ministry of Education (Grant No. 212149), the Fundamental Research Funds for the Central Universities, China (Grant No. 2013121039), and the Program for New Century Excellent Talents in University (NCET-13-0502).

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  1. Bioengineering Program, College of Engineering and Mathematical Sciences, College of Medicine, University of Vermont, Burlington, VT, 05405, USA

    Tianxin Miao

  2. Electrical Engineering Program, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT, 05405, USA

    Yu Zhang

  3. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China

    Yun Zeng, Rui Tian & Gang Liu

  4. Department of Pharmacology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, China

    Yun Zeng

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  1. Tianxin Miao
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  4. Rui Tian
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  5. Gang Liu
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Correspondence to Gang Liu .

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    Zhifei Dai

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Miao, T., Zhang, Y., Zeng, Y., Tian, R., Liu, G. (2016). Functional Nanoparticles for Molecular Imaging-Guided Gene Delivery and Therapy. In: Dai, Z. (eds) Advances in Nanotheranostics II. Springer Series in Biomaterials Science and Engineering, vol 7. Springer, Singapore. https://doi.org/10.1007/978-981-10-0063-8_8

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