Abstract
The family Euphorbiaceae is comprised of 300 genera and some 7500 species widely distributed over the world, especially in the tropical and subtropical regions of the Americas, Africa and Asia. Croton is one of the most important genera of this family that comprises about 1300 species widespread in Africa, Asia and South America. This genus is rich in constituents with biological activities, chiefly diterpenoids such as phorbol esters, clerodane, labdane, kaurane, trachylobane, pimarane, etc. Croton is also rich in alkaloids, flavonoids, triterpenoids and steroids. Several species are aromatic, indicating the presence of volatile oils. Croton zehntneri Pax & K. Hoffm. is native to Northeastern Brazil, where it is often used in folk medicine to treat anxiety, as sedative, appetite stimulating, antianorexigen and for the relief of gastrointestinal disturbances. In view of its popular uses in treating various diseases, this chapter reviews scientific studies on the chemical and biological properties of this species.
Croton zehntneri Pax & K. Hoffm
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Aguiar UN, Lima SG, Rocha MS, Freitas RM, Oliveira TM, Silva RM, Moura LCB, Almeida LTG (2014) Preparation and characterization of the inclusion complex essential oil of Croton zehntneri with β-cyclodextrin. Quim Nova 37(1):50–55
Batatinha MJM, Souza-Spinosa H, Bernardi MM (1995) Croton zehntneri: possible central nervous system effects of the essential oil in rodents. J Ethnopharmacol 45(1):53–57
Bernardi MM, Souza-Spinosa H, Batatinha MJM, Giorgi R (1991) Croton zehntneri: possible central nervous system effects in rodents. J Ethnopharmacol 33(3):285–287
Bracher F, Randau KP, Lerche H (2008) Crototropone, a new tropone derivative from Croton zehntneri. Fitoterapia 79(3):236–237
Cavalcanti JM, Leal-Cardoso JH, Diniz LR, Portella VG, Costa CO, Linard CF, Alves K, Rocha MV, Lima CC, Cecatto VM, Coelho-de-Souza AN (2012) The essential oil of Croton zehntneri and trans-anethole improves cutaneous wound healing. J Ethnopharmacol 144(2):240–247
Coelho-de-Souza AN, Lahlou S, Barreto JE, Yum ME, Oliveira AC, Oliveira HD, Celedônio NR, Feitosa RG, Duarte GP, Santos CF, de Albuquerque AA, Leal-Cardoso JH (2013) Essential oil of Croton zehntneri and its major constituent anethole display gastroprotective effect by increasing the surface mucous layer. Fundam Clin Pharmacol 27(3):288–298
Cordeiro I, Secco R, Carneiro-Torres DS, Lima LR de, Caruzo MBR, Berry P, Riina R, Silva OLM, Silva MJ da, Sodré RC (2015) Croton in Lista de Espécies da Flora do Brasil. Jardim Botânico do Rio de Janeiro. Disponível em: http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB29246. Acesso em: 29 Mai. 2015
Costa JGM, Rodrigues FFG, Angélico EC, Pereira CKB, Souza EO, Caldas GFR, Silva MR, Santos NKA, Mota ML, Santos PF (2008) Chemical composition and evaluation of the antibacterial activity and toxicity of the essential oil of Croton zehntneri (variety estragol). Rev Bras Farmacogn 18(4):583–586
Craveiro AA, Andrade CHS, Matos FJA, Alencar JW (1978) Anise-like flavor Croton aff zehntneri. J Agric Food Chem 26(3):772–773
Craveiro AA, Rodrigues AS, Andrade CHS, Matos FJA, Alencar JW, Machado MIL (1981) Volatile constituents of Brazillian Euphorbiaceae. Genus Croton. J Nat Prod 44(5):602–608
Cunha CSM, Maia SSS, Coelho MFB (2012) Cuttings of Croton zehntneri Pax et Hoffm. at different concentrations of indole butyric acid. Cienc Rural 42(4):621–626
Fernandes AA, Alencar IW, Matos FJA, Craveiro AA, Andrade CHS, Fonteles MC, Viana GSB, Capelo LR, Matos FF (1978). Canelas silvestres nordestinas: aspectos botânicos, químicos e farmacológicos. In: Simpósio de Plantas Medicinais do Brasil, vol 5, 1978. Ciência e Cultura, São Paulo 197, 32:26–36
Fontenelle RO, Morais SM, Brito EH, Brilhante RS, Cordeiro RA, Nascimento NR, Kerntopf MR, Sidrim JJ, Rocha MF (2008) Antifungal activity of essential oils of Croton species from the Brazilian Caatinga biome. J Appl Microbiol 104(5):1383–1390
Giorgi R, Batatinha MJ, Bernardi MM, Souza-Spinosa H, Spinosa FR, Palermo-Neto J (1991) Effects of Croton zehntneri aqueous extracts on some cholinergic- and dopaminergic-related behaviours of laboratory rodents. J Ethnopharmacol 34(2–3):189–193
Lazarini CA, Uema AH, Brandão GMS, Guimarães APC, Bernardi MM (2000) Croton zehntneri essential oil: effects on behavioral models related to depression and anxiety. Phytomedicine 7(6):477–481
Leal-Cardoso JH, Albuquerque AAC, Cecatto VM, Souza ANC (2013). Croton zehntneri Pax et Hoffm. (canela de cunhã). In: Viana GSB, Leal LKAM, Vasconcelos SMM (eds) Plantas medicinais da Caatinga: atividades biológicas e potencial terapêutico. Ed. UFC, 131, 2013
Medeiros VM, Tavares JF, Almeida JRGS, Araujo-Junior VT, Athayde-Filho PF, Cunha EVL, Barbosa-Filho JM, Silva MS (2012). Phytochemistry of the genus Croton. In: Natural products: research reviews, vol 1. Daya Publishing House, New Delhi, pp 217–366
Melo IRS, Teixeira AMR, Sena-Junior DM, Santos HS, Albuquerque MRJR, Bandeira PN, Rodrigues AS, Braz-Filho R, Gusmão GOM, Silva JH, Fariad JLB, Bento RRF (2014 Jan) FT-Raman and FTIR-ATR spectroscopies and DFT calculations of triterpene acetyl aleuritolic acid. J Mol Struct 1058:221–227
Morais SM, Catunda-Junior FEA, Silva ARA, Martins-Neto JS, Rondina D, Leal-Cardoso JH (2006) Antioxidant activity of essential oils from Northeastern Brazilian Croton species. Quim Nova 29(5):907–910
Oliveira AC, Leal-Cardoso JH, Santos CF, Morais SM, Coelho-de-Souza AN (2001 Nov) Antinociceptive effects of the essential oil of Croton zehntneri in mice. Braz J Med Biol Res 34(11):1471–1474
Ramos JMO, Santos CA, Santana DG, Santos DA, Alves PB, Thomazzi SM (2013) Chemical constituents and potential antiinflammatory activity of the essential oil from the leaves of Croton argyrophyllus. Rev Bras Farmacogn 23(4):644–650
Salatino A, Salatino MLF, Negri G (2007) Traditional uses, chemistry and pharmacology of croton species (Euphorbiaceae). J Braz Chem Soc 18(1):11–33
Simionatto E, Bonani VFL, Morel AF, Poppi NR, Raposo-Junior JL, Stuker CZ, Peruzzo GM, Peres MTLP, Hess SC (2007) Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark. J Braz Chem Soc 18(5):879–885
Siqueira RJ, Magalhães PJ, Leal-Cardoso JH, Duarte GP, Lahlou S (2006) Cardiovascular effects of the essential oil of Croton zehntneri leaves and its main constituents, anethole and estragole, in normotensive conscious rats. Life Sci 78(20):2365–2372
Siqueira RJ, Duarte GP, Magalhães PJ, Lahlou S (2013) Cardiovascular effects of the essential oil of Croton zehntneri leaves in DOCA-salt hypertensive, conscious rats. Nat Prod Commun 8(8):1167–1170
Webster GL (1994) Systematics of the euphorbiaceae. In: Annals of the Missouri Botanic Garden, vol 1. EUA, California, n. 81, p 44
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da Silva Almeida, J.R.G., Ramalho, A.C.M., da Silveira, F.G. (2018). Croton zehntneri Pax & K. Hoffm (Euphorbiaceae). In: Albuquerque, U., Patil, U., Máthé, Á. (eds) Medicinal and Aromatic Plants of South America. Medicinal and Aromatic Plants of the World, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1552-0_15
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