Abstract
A high rate of post-neonatal deaths is due to a Respiratory Syncytial Virus (RSV). An early diagnosis with the accurate patient stratification and forecast of disease outcome is vital for an effective treatment. Common diagnostics for the identification of unknown pathogens require large sample volumes and are laborious. In this work, a novel piezoelectric FPW Bio-MEMS sensor based on the frequency shift of a resonating membrane due to binding of an additional mass was developed. The experimental results show that the sensor, a critical part of point-of-care devices, can detect with a high degree of accuracy RSV chemokines in complex media and is much faster than standard methods.
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References
Baker BK (2013) Empowering patients and strengthening communities for real health workforce and funding targets. Bull World Health Organ 91:889
Chan C, Mak W, Cheung K, Sin K, Yu C, Rainer T, Renneberg R (2013) Evidence-based point-of-care diagnostics: current status and emerging technologies. Annu Rev Anal Chem (Palo Alto Calif) 6:191
Point of care testing: applications of microfluidic technologies. Report May 2014 (Yole-Developement, 2014)
Niemz A, Ferguson TM, Boyle DS (2011) Point-of-care nucleic acid testing for infectious diseases. Trends Biotechnol 29:240
Pai NP, Vadnais C, Denkinger C, Engel N, Pai M (2012) Point-of-care testing for infectious diseases: diversity, complexity, and barriers in low- and middle-income countries. PLoS Med 9(9):1
Palamountain KM, Baker J, Cowan EP, Essajee S, Mazzola LT, Metzler M (2012) Perspectives on introduction and implementation of new point-of-care diagnostic tests. J Infect Dis 205(2):181
Peeling RW, McNerney R (2014) Emerging technologies in point-of-care molecular diagnostics for resource-limited settings. Expert Rev Mol Diagn 14:525
WHO (2009) Infant mortality from respiratory diseases. Fact Sheet CODE: RPG3_Air_E2
Bjurstrom J, Yantchev V, Katardjiev I (2006) Thin film Lamb wave resonant structures – the first approach. Solid State Electron 50:322
Shruthi GS, Amitha CV, Mathew BB (2014) Biosensors: a modern day achievement. J Instrum Technol 2(1):26
Rocha-Gaso MI, March-Iborra C, Montoya-Baides A, Arnau-Vives A (2009) Surface generated acoustic wave biosensors for the detection of pathogens: a review. Sensors 9:5740
Huang IY, Lee MC (2006) Development of a novel flexural plate wave biosensor for immunoglobulin-E detection by using SAM and MEMS technologies. In: Proceedings of the 5th IEEE conference on sensors (IEEE sensors 2006), Daegu, 22–25 Oct 2006
Huang IY, Lee MC, Chang YW, Huang RS (2007) Development and characterization of FPW based allergy biosensor. In: Proceedings of the 2007 IEEE international symposium on industrial electronics (IEEE ISIE 2007), Vigo, 4–7 June
Huang IY, Lee MC (2008) Development of a FPW allergy biosensor using NEMS technology. In: Proceedings of the 2008 Asia-Pacific conference on transducers and micro-nano technology (APCOT 2008), Tainan, 22–25 June 2008
Huang IY, Lee MC (2008) Development of a FPW allergy biosensor for human IgE detection by MEMS and cystamine-based SAM technologies. Sens Actuators B 132:340–348
Ballantine DS Jr, White RM, Martin SJ, Ricco AJ, Frye GC, Zellers ET, Wohltjec H (1997) Acoustic wave sensors: theory, design, and physicochemical application. Academic, New York
Bjurstrom J, Yantchev V, Katardjiev I (2006) Thin film Lamb wave resonant structures – the first approach. Solid State Electron 50:322
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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 634415.
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Jupe, A. et al. (2018). Development of a Piezoelectric Flexural Plate-Wave (FPW) Biomems-Sensor for Rapid Point-of-Care Diagnostics. In: Bonča, J., Kruchinin, S. (eds) Nanostructured Materials for the Detection of CBRN. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1304-5_15
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DOI: https://doi.org/10.1007/978-94-024-1304-5_15
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