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Techniques for Crystal Optical Characterisation: Chiroptical Spectroscopy

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Engineering Crystallography: From Molecule to Crystal to Functional Form

Abstract

Solid state can provide unique and novel chemistry which is different from traditional solution chemistry. However, very few solid-state chirality measurements have been reported to date, as chiroptical spectra are inevitably accompanied by artifact signals originated from macroscopic anisotropies of a sample which are unique to the solid state. We have developed chiroptical spectrophotometers which overcome these problems. In this article, principle and instrumentation of Universal Chiroptical Spectrophotometers (UCS-1, UCS-2 and UCS-3) are described. These instruments measure artifact signals as well, which are then removed to obtain true chirality information. UCS-2 and -3 can measure both diffuse reflectance and transmittance CD (circular dichroism) as they have a horizontal sample stage, ideal for soft materials such as gels or powder crystallines. Some examples of the application are presented. The principle of multichannel (MC) CD which is based on an entirely new idea to detect directly true CD, free from artefact signals, is also briefly described.

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Authors and Affiliations

  1. Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba, 278-8510, Japan

    Reiko Kuroda

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  1. Reiko Kuroda
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Correspondence to Reiko Kuroda .

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Editors and Affiliations

  1. School of Chemical & Process Engineering, University of Leeds, Leeds, United Kingdom

    Kevin J. Roberts

  2. Pfizer Global R&D, Pharmaceutical Sciences, Pfizer Global R&D, Sandwich, Kent, United Kingdom

    Robert Docherty

  3. Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto, Japan

    Rui Tamura

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Kuroda, R. (2017). Techniques for Crystal Optical Characterisation: Chiroptical Spectroscopy. In: Roberts, K., Docherty, R., Tamura, R. (eds) Engineering Crystallography: From Molecule to Crystal to Functional Form. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1117-1_24

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