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Viedma Ripening and Its Role in the Chiral Separation of Optical Isomers

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Engineering Crystallography: From Molecule to Crystal to Functional Form

Abstract

It has recently been observed that a mixture of two enantiomeric crystals subjected to attrition in a solution containing a racemizing agent undergoes symmetry breaking, with only one of the enantiomers eventually remaining in solid form. This process is believed to occur due to the interplay between racemization in solution, attrition, agglomeration and crystal growth and dissolution caused by the crystal size dependence of solubility. This process is called Viedma ripening and is one of the most fascinating and complex crystallisation processes. In this work, we present a commented review of the most recent literature on Viedma ripening and related topics.

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Authors and Affiliations

  1. Institute of Process Engineering, Eidgenössische Technische Hochschule Zurich, CH-8092, Zurich, Switzerland

    Martin Iggland, Giovanni Maria Maggioni & Marco Mazzotti

Authors
  1. Martin Iggland
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  2. Giovanni Maria Maggioni
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  3. Marco Mazzotti
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Correspondence to Marco Mazzotti .

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Editors and Affiliations

  1. School of Chemical & Process Engineering, University of Leeds, Leeds, United Kingdom

    Kevin J. Roberts

  2. Pfizer Global R&D, Pharmaceutical Sciences, Pfizer Global R&D, Sandwich, Kent, United Kingdom

    Robert Docherty

  3. Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto, Japan

    Rui Tamura

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Iggland, M., Maggioni, G.M., Mazzotti, M. (2017). Viedma Ripening and Its Role in the Chiral Separation of Optical Isomers. In: Roberts, K., Docherty, R., Tamura, R. (eds) Engineering Crystallography: From Molecule to Crystal to Functional Form. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1117-1_20

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