Abstract
Sonocrystallization is the application of ultrasound to influence crystallization processes. The most widely practiced approach is to initiate controlled nucleation to manage product particle size. This chapter describes the equipment which can be used and how this is applied particularly in pharmaceutical crystallization processes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Mason TJ, Lorimer JP (2002) Applied sonochemistry, the uses of power ultrasound in chemistry and processing. Wiley-VCH, Weinheim
Suslick KS, Price GJ (1999) Application of ultrasound to materials chemistry. Annu Rev Mater Sci 29:295–326
Price CJ, Martin PD, McCausland LJ, Ruddick S, Hobden I (1995) Sonocrystallization - designing better crystals for the pharmaceutical industry American institution of chemical engineers 1995 annual meeting p222b Miami Beach 12–17 November
Kim YH, Lee K, Koo KK, Shul YG, Haam S (2002) Comparison study of mixing effect on batch cooling crystallization of 3-nitro-1,2,4-triazol-5-one (NTO) using mechanical stirrer and ultrasound irradiation. Cryst Res Technol 37(9):928–944
Roberts CW, Hira SM, Mason BP, Strouse GF, Stoltz CA (2011) Controlling RDX explosive crystallite morphology and inclusion content via simple ultrasonic agitation and solvent evaporation. CrystEngComm 13:1074–1076
Ruecroft G, Hipkiss D, Fennell M (2005) Improving the Bayer process by power ultrasound induced crystallization of key impurities. The Minerals, Metals and Materials Society Light Metals, New York, pp 163–166
Wood RW, Loomis AL (1927) Physical and biological effects of high-frequency sound waves. Philos Mag 4:417–436
Umbdenstock RR (1955) Preparation of Procaine Penicillin. US patent 2,727,892 20th Dec 1955
Principe JR, Skauen DM (1962) Preparation of microcrystalline progesterone using ultrasound. J Pharm Sci 51:389–390
Hem SL (1967) The effect of ultrasonic vibrations on crystallization processes. Ultrasonics 5(4):202–207
Hem SL, Skauen DM, Beal HM (1967) Mechanism of crystallization of hydrocortisone by ultrasonic irradiation. J Pharm Sci 56(2):229–233
Wagterveld RL, Boels M, Mayer MJ, Witkamp GJ (2011) Visualization of acoustic cavitation effects on suspended calcite crystals. Ultrason Sonochem 18(1):216–225
Zeiger BW, Suslick KS (2011) Sonofragmentation of molecular crystals. J Am Chem Soc 133(37):14530–14533
Anderson HW, Carberry JB, Staunton HF, Sutradhar BC (1994) Crystallization of adipic acid. US 5471001 A 15 Dec 1994
Gracin S, Uusi-Penttila M, Rasmuson A (2005) Influence of ultrasound on the nucleation of polymorphs of p-amino benzoic acid. Cryst Growth Des 5(5):1787–1794
Price CJ (1997) Ultrasound the key to better crystals for the pharmaceutical industry. Pharmaceutical Technology Europe October 78–86
Guo Z, Zhang M, Li H, Wang J, Kougoulos E (2004) Effect of ultrasound on anti-solvent crystallization. J Cryst Growth 273:555–563
Cross WI, Hannan ML, Johns DM, Lee M-Y, Price CJ (2006) Novel crystalline pharmaceutical product. US 2009/0124585 A1 6 Apr 2006
Price CJ (2012) Developing pharmaceutical continuous crystallization processes - knowledge & gaps. Presented at the National Centre for Continuous Manufacturing and Crystallization annual conference September 2012. Available on line: http://www.cmac.ac.uk/files/media/Chris_Price_-_GSK.pdf Accessed 29th October 2015
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Science+Business Media B.V.
About this chapter
Cite this chapter
Price, C.J. (2017). Application of Ultrasound in Crystallization (Sonocrystallization). In: Roberts, K., Docherty, R., Tamura, R. (eds) Engineering Crystallography: From Molecule to Crystal to Functional Form. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1117-1_18
Download citation
DOI: https://doi.org/10.1007/978-94-024-1117-1_18
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-024-1115-7
Online ISBN: 978-94-024-1117-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)