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Mass Spectrometry and High Resolution Mass Spectrometry: An Overview

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Molecular Technologies for Detection of Chemical and Biological Agents

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Abstract

In this chapter, a brief overview of fundamentals in mass spectrometry and some applications are presented. The main concepts in ionization techniques, classical techniques and ambient mass spectrometry are followed by an overview on analyzers.

Particular attention has been paid to high resolution mass spectrometry and accurate mass measurements, highly debating topics in modern mass spectrometry, with some examples and applications. Finally tandem mass spectrometry, collision-induced dissociations (CID), interactions of ions with electrons (ECD, ETD), photons (IRMPD) and with surfaces (SID) are also briefly presented.

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Author information

Authors and Affiliations

  1. Department of Biotechnology, Chemistry & Pharmacy, University of Siena, Via Aldo Moro, I-53100, Siena, Italy

    Gianluca Giorgi

Authors
  1. Gianluca Giorgi
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Correspondence to Gianluca Giorgi .

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Editors and Affiliations

  1. Fisheries and Oceans Canada, Science Branch, Special Projects, Chemistry Department, Memorial University, St. John’s, Newfoundland and Labrador, Canada

    Joseph H. Banoub

  2. Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Richard M. Caprioli

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Giorgi, G. (2017). Mass Spectrometry and High Resolution Mass Spectrometry: An Overview. In: Banoub, J., Caprioli, R. (eds) Molecular Technologies for Detection of Chemical and Biological Agents. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1113-3_5

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