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TRPC Channels and Parkinson’s Disease

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Transient Receptor Potential Canonical Channels and Brain Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 976))

Abstract

Parkinson’s disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson’s disease; however, almost all of them are directly or indirectly dependent on Ca2+ signaling. Importantly, though disturbances in Ca2+ homeostasis have been implicated in Parkinson’s disease and other neuronal diseases, the identity of the calcium channel remains elusive. Members of the transient receptor potential canonical (TRPC) channel family have been identified as a new class of Ca2+ channels, and it could be anticipated that these channels could play important roles in neurodegenerative diseases, especially in PD. Thus, in this chapter we have entirely focused on TRPC channels and elucidated its role in PD.

Pramod Sukumaran and Yuyang Sun contributed equally

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Acknowledgments

We thank the grant support from the NIH (DE017102; DE024300; GM113123) awarded to B.B.S, and the assistance of John Lee, School of Medicine and Health Sciences, in making the figures.

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  1. Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA

    Pramod Sukumaran, Yuyang Sun, Anne Schaar, Senthil Selvaraj & Brij B. Singh

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  1. Pramod Sukumaran
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Correspondence to Brij B. Singh .

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  1. Center of Cognition and Brain Science, Institute of Basic Medical Science, Beijing, China

    Yizheng Wang

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Sukumaran, P., Sun, Y., Schaar, A., Selvaraj, S., Singh, B.B. (2017). TRPC Channels and Parkinson’s Disease. In: Wang, Y. (eds) Transient Receptor Potential Canonical Channels and Brain Diseases. Advances in Experimental Medicine and Biology, vol 976. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1088-4_8

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