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Taurine Have Neuroprotective Activity against Oxidative Damage-Induced HT22 Cell Death through Heme Oxygenase-1 Pathway

  • Conference paper
Taurine 10

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 975))

Abstract

Glutamate-induced oxidative neurotoxicity plays a part role in neuronal degeneration on the disorders of central nervous system (CNS). The expression of heme oxygenase (HO)-1 mediated by Inducible nuclear factor-E2-related factor 2 (Nrf2) functions as an anti-oxidants that is able to play an important role in the pathogenesis of several neuronal disorders. In the present study, taurine showed the inhibitory effect against reactive oxygen species (ROS) induction and protective effects against neurotoxicity induced by glutamate- and H2O2 through induction of HO-1 expression in HT22 cells. Moreover, taurine promoted the Nrf2 nuclear translocation in HT22 cells. We also verified the oxidative stress-mediated cell death of HT22 cells was significantly repressed by taurine, using tin protoporphyrin (SnPP) as an HO activity inhibitor. In addition, we found that treatment of the cells with p38 inhibitor (SB203580) suppressed taurine-induced HO-1 expression and cytoprotection, but inhibitors of c-Jun NH2 terminal kinase (JNK) (SP600125) or extracellular signal regulated kinase (ERK) (PD98059) did not. These results suggest that taurine improves the resistance against oxidative damages induced by glutamate in HT22 cells via the p38/Nrf2-dependent HO-1 expression. Our results demonstrated the potential application of taurine as a therapeutic agent for neurodegenerative diseases.

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Abbreviations

CNS:

Central nervous system

ERK:

Extracellular signal-regulated kinase

HO-1:

Heme oxygenase-1

JNK:

c-Jun NH2-terminal kinase

Nrf2:

Nuclear factor E2-related factor 2

ROS:

Reactive oxygen species

SnPP:

Tin protoporphyrin

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Acknowledgements

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) (No. 2015R1C1A1A02036465).

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Authors and Affiliations

  1. College of Pharmacy, Chosun University, Dong-gu, Gwangju, 61452, South Korea

    Dong-Sung Lee

  2. Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu, 550-749, South Korea

    Sun Hee Cheong

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  1. Dong-Sung Lee
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  2. Sun Hee Cheong
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Correspondence to Sun Hee Cheong .

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Editors and Affiliations

  1. Department of Life Sciences, University of Seoul, Seoul, South Korea

    Dong-Hee Lee  & Ha Won Kim  & 

  2. College of Medicine, University of South Alabama, Mobile, Alabama, USA

    Stephen W. Schaffer

  3. Department of Developmental Neurobiology, NY State Institute for Basic Research in Developmental Disabilities, New York, USA

    Eunkyue Park

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Lee, DS., Cheong, S.H. (2017). Taurine Have Neuroprotective Activity against Oxidative Damage-Induced HT22 Cell Death through Heme Oxygenase-1 Pathway. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_14

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