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Taurine Chloramine Prevents Neuronal HT22 Cell Damage Through Nrf2-Related Heme Oxygenase-1

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Taurine 10

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 975))

Abstract

Oxidative cell damages are able to contribute to neuronal degeneration in several diseases of the central nervous system (CNS) including stroke as well as ischemia. Heme oxygenase (HO)-1 plays a major role in the pathogenesis of neuronal disorder. Taurine chloramine (TauCl) has been shown to possess strong neuronal activities; however, the direct effects of TauCl on neuronal cell death remain to be determined. Therefore, this study was designed to assess the neuroprotective effect of TauCl using oxidative stress-stimulated mouse hippocampal HT22 cells. TauCl showed protective effects against oxidative stress-induced neurotoxicity and inhibited the reactive oxygen species (ROS) production by inducing the heme oxygenase (HO)-1 expression in HT22 cells. TauCl upregulated HO-1 expression and it also increased the nuclear factor E2-related factor 2 (Nrf2) translocation to nuclear. Using an inhibitor of HO-1 activity, we verified that the oxidative stress-related HT22 cell death was significantly suppressed by TauCl. In addition, we found reduced TauCl-induced HO-1 expression and cytoprotection following treatment of the cells with an extracellular signal-regulated kinase (ERK) inhibitor (PD98059) or a p38 inhibitor (SB203580), but not following treatment with a SP600125 as a c-Jun NH2-terminal kinase (JNK) inhibitor. These findings suggest that TauCl improves cellular damage induced by glutamate or H2O2 through ERK and p38, Nrf2, and HO-1 pathways in HT22 cells.

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Abbreviations

CNS:

Central nervous system

ERK:

Extracellular signal regulated kinase

HO:

Heme oxygenase

JNK:

c-Jun NH2 terminal kinase

Nrf2:

Nuclear factor E2-related factor 2

ROS:

Reactive oxygen species

SnPP:

Tin protoporphyrin

TauCl:

Taurine chloramine

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Acknowledgements

This study was financially supported by Chonnam National University, 2016.

Author information

Authors and Affiliations

  1. Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu, 550-749, South Korea

    Sun Hee Cheong

  2. College of Pharmacy, Chosun University, Dong-gu, Gwangju, 61452, South Korea

    Dong-Sung Lee

Authors
  1. Sun Hee Cheong
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  2. Dong-Sung Lee
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Corresponding authors

Correspondence to Sun Hee Cheong or Dong-Sung Lee .

Editor information

Editors and Affiliations

  1. Department of Life Sciences, University of Seoul, Seoul, South Korea

    Dong-Hee Lee  & Ha Won Kim  & 

  2. College of Medicine, University of South Alabama, Mobile, Alabama, USA

    Stephen W. Schaffer

  3. Department of Developmental Neurobiology, NY State Institute for Basic Research in Developmental Disabilities, New York, USA

    Eunkyue Park

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Cheong, S.H., Lee, DS. (2017). Taurine Chloramine Prevents Neuronal HT22 Cell Damage Through Nrf2-Related Heme Oxygenase-1. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_13

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