Abstract
No single method for predicting a protein’s function from its three-dimensional structure is perfect; some methods work well in some cases, whereas other methods perform better in others. Consequently, it makes sense to apply a number of different predictive methods to a given protein structure and obtain either a consensus or the most likely prediction from them all. In this chapter we describe two web servers, ProKnow (http://proknow.mbi.ucla.edu) and ProFunc (http://www.ebi.ac.uk/profunc), that use a cocktail of methods for predicting function from 3D structure.
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Acknowledgements
The author would like to thank Debnath Pal for help with ProKnow and for his useful comments on this chapter.
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Laskowski, R.A. (2017). Integrated Servers for Structure-Informed Function Prediction. In: J. Rigden, D. (eds) From Protein Structure to Function with Bioinformatics. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1069-3_13
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