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Aquaporins in Cardiovascular System

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Aquaporins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 969))

Abstract

Recent studies have shown that some aquaporins (AQPs ), including AQP1, AQP4, AQP7 and AQP9, are expressed in endothelial cells, vascular smooth muscle cells and heart of cardiovascular system. These AQPs are involved in the cardiovascular function and in pathological process of related diseases, such as cerebral ischemia , congestion heart failure , hypertension and angiogenesis. Therefore, it is important to understand the accurate association between AQPs and cardiovascular system, which may provide novel approaches to prevent and treat related diseases. Here we will discuss the expression and physiological function of AQPs in cardiovascular system and summarize recent researches on AQPs related cardiovascular diseases.

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Acknowledgements

Research in the author’s laboratory is supported by the National Natural Science Foundation of China No. 81473235, 81673453, 91129727, 81673486, 81270049 to X.-J. Li, No. 81673486, 81373405 and 30901803 to L. Tie, Research Fund from Ministry of Education of China (111 Projects No. B07001), Beijing Higher Education Young Elite Teacher Project (No. YETP0053) and the Fund of Janssen Research Council China (JRCC2011).

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Authors and Affiliations

  1. State Key Laboratory of Natural and Biomimetic Drugs, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China

    Lu Tie Ph.D. & Xuejun Li M.S.

  2. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China

    Di Wang B.S. & Yundi Shi B.S.

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  1. Lu Tie Ph.D.
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  2. Di Wang B.S.
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  3. Yundi Shi B.S.
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Correspondence to Xuejun Li M.S. .

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  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Baoxue Yang

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Tie, L., Wang, D., Shi, Y., Li, X. (2017). Aquaporins in Cardiovascular System. In: Yang, B. (eds) Aquaporins. Advances in Experimental Medicine and Biology, vol 969. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1057-0_6

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