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Translational Research in Drug Discovery and Development

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Translational Bioinformatics and Its Application

Part of the book series: Translational Medicine Research ((TRAMERE))

Abstract

Translational research facilitates the application of basic scientific discoveries in clinical and community settings to prevent and treat human diseases. The translation of knowledge and innovations from basic laboratory experiments to point-of-care patient applications; production of new drugs, devices, and healthcare products; and promising treatments for patients is referred to as benchside to bedside transition. Numerous opportunities encompass translational research. However, there are several obstacles involved in the process that make the translational journey quite challenging. The major challenges that hamper the growth of translational research include insufficient resources, inadequate funding and infrastructure, shortage of qualified researchers, and lack of sufficient experience in essential techniques. Translational drug discovery and development is an exceedingly difficult, expensive, time-consuming, and risky process. Despite thousands of pharmaceutical companies working to develop and get new drugs to market, and billions of dollars spent every year, only a few new molecular entities (NMEs) receive marketing approval from the FDA per year. Translational drug discovery demands both the need for cooperation between clinical and pharmacological research and the significance of the role of academia in target identification and drug discovery, design, and development. This chapter highlights an overview of translational research in a drug discovery and development perspective. We further discussed associated opportunities and challenges, as well as possible strategies that could be used to overcome the challenges. Certain strategies like prioritizing research area, clearer vision on the project, committed team of researchers, established infrastructure, sufficient funding, and meaningful collaborations could be highly beneficial in accelerating the hunt to discover new drugs and for the establishment of successful translational drug discovery process.

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Abbreviations

BrIDGs:

Bridging Interventional Development Gaps

FASEB:

Federation of American Societies for Experimental Biology

FDA:

Food and Drug Administration

GWAS:

Genome-wide association study

ITHS:

Institute of Translational Health Sciences

MHRA:

Medicines and Healthcare Products Regulatory Agency

NCATS:

National Center for Advancing Translational Science

NCI:

National Cancer Institute

NIH:

National Institutes of Health

TRWG:

Translational Research Working Group

CRC:

Colorectal cancer

ALL:

Acute lymphoblastic leukemia

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Author information

Authors and Affiliations

  1. Department of Botany, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India

    Neha Arora

  2. Amity Institute of Biotechnology, Amity University, Sector-125, Noida, Uttar Pradesh, 201313, India

    Pawan Kumar Maurya

  3. Interdisciplinary Laboratory of Clinical Neurosciences (LiNC), Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil

    Pawan Kumar Maurya

  4. Pharma Analytics Division, Excelra Knowledge Solutions Pvt. Ltd., 6th floor, Wing B, NSL SEZ Arena, Plot No. 6, Survey No. 1, IDA Uppal, Hyderabad, Telangana, 500039, India

    Puneet Kacker

Authors
  1. Neha Arora
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  2. Pawan Kumar Maurya
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  3. Puneet Kacker
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Corresponding author

Correspondence to Puneet Kacker .

Editor information

Editors and Affiliations

  1. State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

    Dong-Qing Wei

  2. Center for Neurosciences, The Feinstein Institute for Medical Research, New York, USA

    Yilong Ma

  3. Department of Molecular Medicine, Hofstra Northwell School of Medicine, New York, USA

    William C.S. Cho

  4. Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, Hong Kong

    Qin Xu

  5. College of Computer Science & Technology, Jilin University, Changchun, Jilin, China

    Fengfeng Zhou

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© 2017 Shanghai Jiao Tong University Press, Shanghai and Springer Science+Business Media Dordrecht

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Arora, N., Maurya, P.K., Kacker, P. (2017). Translational Research in Drug Discovery and Development. In: Wei, DQ., Ma, Y., Cho, W., Xu, Q., Zhou, F. (eds) Translational Bioinformatics and Its Application. Translational Medicine Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1045-7_3

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