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Chemical Risk Characterization

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Public Health Risk Assessment for Human Exposure to Chemicals

Part of the book series: Environmental Pollution ((EPOL,volume 27))

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Abstract

Fundamentally, risk characterization consists of estimating the probable incidence of adverse impacts to potential receptors, under the various exposure conditions associated with a chemical hazard situation. It involves an integration of the hazard effects and exposure assessments—in order to arrive at an estimate of the health risk to the exposed population. In general, all information derived from each step of a chemical exposure-cum-hazard assessment are integrated and utilized during the risk characterization—so as to help project the degree and severity of adverse health effects in the populations potentially at risk.

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Suggested Reading

  • Bogen, K. T. (2014a). Does EPA underestimate cancer risks by ignoring susceptibility differences? Risk Analysis, 34(10), 1780–1784.

    Article  Google Scholar 

  • Bogen, K. T. (2014b). Unveiling variability and uncertainty for better science and decisions on cancer risks from environmental chemicals. Risk Analysis, 34(10), 1795–1806.

    Article  Google Scholar 

  • Callahan, M. A., & Sexton, K. (2007). If ‘cumulative risk assessment’ is the answer, what is the question? Environmental Health Perspectives, 115(5), 799–806.

    Article  CAS  Google Scholar 

  • Feron, V., van Vliet, P., & Notten, W. (2004). Exposure to combinations of substances: A system for assessing health risks. Environmental Toxicology and Pharmacology, 18, 215–222.

    Article  CAS  Google Scholar 

  • Finkel, A. M. (2013). Protecting the cancer susceptibility curve. Environmental Health Perspectives, 121(8), A238.

    Article  Google Scholar 

  • Finkel, A. M. (2014). EPA underestimates, oversimplifies, miscommunicates, and mismanages cancer risks by ignoring susceptibility. Risk Analysis, 34(10), 1785–1794.

    Article  Google Scholar 

  • Goldman, M. (1996). Cancer risk at low-level exposure. Science, 271, 1821–1822.

    Article  CAS  Google Scholar 

  • Goodrich, M. T., & McCord, J. T. (1995). Quantification of uncertainty in exposure assessment at hazardous waste sites. Ground Water, 33(5), 727–732.

    Article  CAS  Google Scholar 

  • Heidenreich, W. F. (2005). Heterogeneity of cancer risk due to stochastic effects. Risk Analysis, 25(6), 1589–1594.

    Article  Google Scholar 

  • Law, A. M., & Kelton, W. D. (1991). Simulation modeling and analysis. New York, NY: McGraw-Hill.

    Google Scholar 

  • Maxwell, R. M., & Kastenberg, W. E. (1999). Stochastic environmental risk analysis: An integrated methodology for predicting cancer risk from contaminated groundwater. Stochastic Environmental Research and Risk Assessment, 13, 27–47.

    Article  Google Scholar 

  • Nendza, M. (1997). Structure-activity relationships in environmental sciences. Dordrecht: Kluwer Academic Publishers.

    Google Scholar 

  • Phelan, M. J. (1998). Environmental health policy decisions: The role of uncertainty in economic analysis. Journal of Environmental Health, 61(5), 8–13.

    Google Scholar 

  • Richards, D., & Rowe, W. D. (1999). Decision-making with heterogeneous sources of information. Risk Analysis, 19(1), 69–81.

    Google Scholar 

  • Sarigiannis, D., & Hansen, U. (2012). Considering the cumulative risk of mixtures of chemicals—A challenge for policy makers. Environmental Health, 11(1), S18.

    Article  Google Scholar 

  • USEPA. (1997). Guiding principles for Monte Carlo analysis. Washington, DC: EPA/630/R-97/001, Risk Assessment Forum, Office of Research and Development, US Environmental Protection Agency (USEPA).

    Google Scholar 

  • USEPA. (1999). Report of the workshop on selecting input distributions for probabilistic assessments. Washington, DC: EPA/630/R-98/004, Risk Assessment Forum, Office of Research and Development, US Environmental Protection Agency (USEPA).

    Google Scholar 

  • USEPA (U.S. Environmental Protection Agency). (2003). Framework for cumulative risk assessment. Washington, DC: EPA/600/P-02/001F, National Center for Environmental Assessment, Risk Assessment Forum, U.S. Environmental Protection Agency.

    Google Scholar 

  • West, G. B., Brown, J. H., & Enquist, B. J. (1997). A general model of the origin of allometric scaling laws in biology. Science, 276, 122–126.

    Article  CAS  Google Scholar 

Bibliography

  • Bogen, K. T. (1994). A note on compounded conservatism. Risk Analysis, 14, 379–381.

    Article  Google Scholar 

  • Callahan, M. A., & Sexton, K. (2007). If cumulative risk assessment is the answer, what is the question? Environmental Health Perspectives, 115(5), 799–806.

    Article  CAS  Google Scholar 

  • CAPCOA. (1990). Air toxics “Hot Spots” program. Risk assessment guidelines. California: California Air Pollution Control Officers Association (CAPCOA).

    Google Scholar 

  • CDHS. (1986). The California site mitigation decision tree manual. Sacremento, CA: California Department of Health Services (CDHS), Toxic Substances Control Division.

    Google Scholar 

  • Clayton, C. A., Pellizari, E. D., & Quackenboss, J. J. (2002). National human exposure assessment survey: Analysis of exposure pathways and routes for arsenic and lead in EPA Region 5. Journal of Exposure Analysis and Environmental Epidemiology, 12(1), 29–43.

    Article  CAS  Google Scholar 

  • Cohrssen, J. J., & Covello, V. T. (1989). Risk analysis: A guide to principles and methods for analyzing health and environmental risks. Springfield, VA: National Technical Information Service (NTIS), US Dept. of Commerce.

    Google Scholar 

  • DTSC. (1994a). CalTOX, A multimedia exposure model for hazardous waste sites. Sacramento, CA: Office of Scientific Affairs, CalEPA/DTSC.

    Google Scholar 

  • DTSC. (1994b). Preliminary endangerment assessment guidance manual (A guidance manual for evaluating hazardous substance release sites). Sacramento, CA: California Environmental Protection Agency, Department of Toxic Substances Control (DTSC).

    Google Scholar 

  • IARC. (1987). IARC monographs on the evaluation of carcinogenic risks of chemicals to humans: Overall evaluations of carcinogenicity, Supplement 7. Lyon, France: International Agency for Research on Cancer (IARC).

    Google Scholar 

  • Johnson, B. L., & Jones, D. E. (1992). ATSDR's activities and views on exposure assessment. Journal of Exposure Analysis and Environmental Epidemiology, Suppl., 1, 1–17.

    Google Scholar 

  • Klaassen, C. D. (Ed.). (2001). Casarett and Doull’s toxicology: The basic science of poisons (6th ed.). New York: McGraw-Hill.

    Google Scholar 

  • Kodell, R. L., & Chen, J. J. (1994). Reducing conservatism in risk estimation for mixtures of carcinogens. Risk Analysis, 14, 327–332.

    Article  CAS  Google Scholar 

  • NRC. (1983). Risk Assessment in the Federal Government: Managing the Process, National Research Council, Committee on the Institutional Means for Assessment of Risks to Public Health. Washington, DC: National Academy Press.

    Google Scholar 

  • NRC. (1991a). Environmental Epidemiology (Public Health and Hazardous Wastes). Washington, DC: National Academy Press.

    Google Scholar 

  • NRC. (1991b). Frontiers in Assessing Human Exposure to Environmental Toxicants. Washington, DC: National Academy Press.

    Google Scholar 

  • NRC. (1991c). Human Exposure Assessment for Airborne Pollutants: Advances and Opportunities. Washington, DC: National Academy Press.

    Google Scholar 

  • NRC. (2009). Science and decisions: Advancing risk assessment. Washington, DC: Committee on Improving Risk Analysis Approaches Used by the U.S. EPA The National Academies Press.

    Google Scholar 

  • NTP. (1991). Sixth annual report on carcinogens, National Toxicology Program (NTP). Washington, DC: US Department of Health and Human Services, Public Health Service.

    Google Scholar 

  • Safe, S. H. (1998). Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach. Environmental Health Perspectives, 106(Suppl.4), 1051–1058.

    Article  CAS  Google Scholar 

  • Shields, P. G., & Harris, C. C. (1991). Molecular epidemiology and the genetics of environmental cancer. Journal of American Medical Association, 266, 681–687.

    Article  CAS  Google Scholar 

  • Slob, W. (1994). Uncertainty analysis in multiplicative models. Risk Analysis, 14, 571–576.

    Article  Google Scholar 

  • USEPA (US Environmental Protection Agency). (1984a). Approaches to risk assessment for multiple chemical exposures (EPA-600/9-84-008), Environmental Criteria and Assessment Office, US Environmental Protection Agency (USEPA), Cincinnati, OH.

    Google Scholar 

  • USEPA. (1986a). Ecological risk assessment. Hazard Evaluation Division Standard Evaluation Procedure, Washington, DC.

    Google Scholar 

  • USEPA. (1986b). Guidelines for the health risk assessment of chemical mixtures (EPA/630/R-98/002), Risk Assessment Forum, Office of Research and Development, US Environmental Protection Agency (USEPA), Washington, DC.

    Google Scholar 

  • USEPA. (1986c). Guidelines for carcinogen risk assessment (EPA/630/R-00/004), September 1986. US EPA, Office of Research and Development, National Center for Environmental Assessment, Washington, DC.

    Google Scholar 

  • USEPA. (1986d). Guidelines for mutagenicity risk assessment (EPA/630/R-98/003), Risk Assessment Forum, Office of Research and Development, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1986e). Methods for assessing exposure to chemical substances, volume 8: Methods for assessing environmental pathways of food contamination (EPA/560/5-85-008), Exposure Evaluation Division, Office of Toxic Substances, Washington, DC.

    Google Scholar 

  • USEPA. (1986f). Superfund public health evaluation manual (EPA/540/1-86/060), Office of Emergency and Remedial Response, Washington, DC.

    Google Scholar 

  • USEPA. (1989a). Exposure factors handbook (EPA/600/8-89/043), Office of Health and Environmental Assessment, Washington, DC.

    Google Scholar 

  • USEPA. (1989d). Methods for evaluating the attainment of cleanup standards. Volume I: Soils and solid media. EPA/230/2-89/042. Office of Policy, Planning and Evaluation, Washington, DC.

    Google Scholar 

  • USEPA. (1992a). Dermal exposure assessment: Principles and applications. EPA/600/8-91/011B, Office of Health and Environmental Assessment, US EPA, Washington, DC.

    Google Scholar 

  • USEPA. (1992b). Framework for ecological risk assessment. EPA/630/R-92/001, February, 1992, Risk Assessment Forum, Washington, DC.

    Google Scholar 

  • USEPA. (1992c). Guidance for data useability in risk assessment (Parts A & B), Publication No. 9285.7-09A&B, Office of Emergency and Remedial Response, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1992d). Guidelines for exposure assessment, EPA/600/Z-92/001, Risk Assessment Forum, Office of Research and Development, Office of Health and Environmental Assessment, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1992e). Supplemental guidance to RAGS: Calculating the concentration term. Publication No. 9285.7-08I, Office of Emergency and Remedial Response, USEPA, Washington, DC

    Google Scholar 

  • USEPA. (1994a). Ecological risk assessment issue papers. EPA/630/R-94/009, Risk Assessment Forum, Washington, DC.

    Google Scholar 

  • USEPA. (1994b). Estimating exposures to dioxin-like compounds. EPA/600/6-88/005Cb, Office of Research and Development, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1994c). Estimating radiogenic cancer risks. EPA 402-R-93-076, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1994d). Guidance for the data quality objectives process. EPA/600/R-96/055. Office of Research and Development, Washington, DC.

    Google Scholar 

  • USEPA. (1994e). Guidance manual for the integrated exposure uptake biokinetic model for lead in children. EPA/540/R-93/081, Office of Emergency and Remedial Response, US Environmental Protection Agency (USEPA), Washington, DC.

    Google Scholar 

  • USEPA. (1994f). Radiation site cleanup regulations: Technical support document for the development of radionuclide cleanup levels for soil. EPA 402-R-96-011A, September 1994.

    Google Scholar 

  • USEPA. (1994g). Methods of derivation of inhalation reference concentrations and application of inhalation dosimetry. Office of Research and Development, Research Triangle Park, NC.

    Google Scholar 

  • USEPA. (1996a). Guidelines for reproductive toxicity risk assessment. EPA/630-96/009, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1996b). Interim approach to assessing risks associated with adult exposures to lead in soil. US Environmental Protection Agency (USEPA), Washington, DC.

    Google Scholar 

  • USEPA. (1996c). PCBs: Cancer dose-response assessment and application to environmental mixtures. EPA/600/P-96/001F, September 1996, National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • USEPA. (1996d). Radiation exposure and risk assessment manual. EPA 402-R-96-016, US Environmental Protection Agency (USEPA), Washington, DC.

    Google Scholar 

  • USEPA. (1996e). Soil screening guidance: Technical background document, EPA/540/R-95/128. Office of Emergency and Remedial Response, Washington, DC.

    Google Scholar 

  • USEPA. (1996f). Soil screening guidance: User’s Guide, EPA/540/R-96/018. Office of Emergency and Remedial Response, Washington, DC.

    Google Scholar 

  • USEPA. (1997a). Ecological risk assessment guidance for superfund: Process for designing and conducting ecological risk assessments (ERAGS, EPA 540-R-97-006, OSWER Directive # 9285.7-25, June 1997), US Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • USEPA. (1997b). Establishment of cleanup levels for CERCLA sites with radioactive contamination. OSWER Directive 9200.4-18, August 1997.

    Google Scholar 

  • USEPA. (1997c). Estimating radiogenic cancer risks. USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1997d). Exposure factors handbook, Volumes I through III. EPA/600/0-95-002Fa, Fb, Fc, Office of Research and Development, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1997e). Guiding principles for Monte Carlo analysis. EPA/630/R-97/001, Office of Research and Development, Risk Assessment Forum, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1997f). Policy for use of probabilistic analysis in risk assessment. EPA/630/R-97/001, Office of Research and Development, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1997g). The lognormal distribution in environmental applications. EPA/600/r-97/006, Office of Research and Development/Office of Solid Waste and Emergency Response, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (1997h). Users guide for the Johnson and Ettinger (1991) model for subsurface vapor intrusion into buildings. Office of Emergency and Remedial Response, USEPA, Washington, DC.

    Google Scholar 

  • USEPA. (2000). Science policy handbook: Risk characterization. Science Policy Council, Washington, DC; EPA/100/B/00/002.

    Google Scholar 

  • USEPA. (2003a). Framework for cumulative risk assessment. EPA/600/P- 02/001F. National Center for Environmental Assessment, Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • USEPA. (2004a). Community air screening how-to manual. A step-by-step guide to using risk-based screening to identify priorities for improving outdoor air quality. EPA 744-B-04-001. U.S. Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • USEPA. (2004b). Risk assessment guidance for Superfund: Volume 1—Human health evaluation manual (Part E, supplemental guidance for dermal risk assessment). Final, July 2004. EPA/540/R/99/005. Office of Emergency and Remedial Response, US Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • USEPA. (2004c). Example Exposure Scenarios. EPA/600/R-03/036. Center for Environmental Assessment, US Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • USEPA. (2004d). Risk assessment principles and practices. Staff Paper, EPA/100/B-04/001. Office of the Science Advisor, U.S. Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • USEPA. (2004e). User’s guide for evaluating subsurface vapor intrusion into buildings. Office of Emergency and Remedial Response, Washington, DC.

    Google Scholar 

  • USEPA. (2004f). Air quality criteria for particulate matter: Volume II. Office of Research and Development, Washington, D.C. EPA/600/P-95/001bF.

    Google Scholar 

  • USEPA. (2004g). An examination of EPA risk assessment principles and practices. Washington, DC: Office of the Science Advisor, Environmental Protection Agency.

    Google Scholar 

  • USEPA. (2005a). Guidelines for Carcinogen risk assessment. EPA/630/P-03/001B, March 2005. US EPA, Office of Research and Development, National Center for Environmental Assessment, Washington, DC.

    Google Scholar 

  • USEPA. (2006a). Approaches to the application of physiologically based pharmacokinetic (PBPK) models and supporting data in risk assessment (Final Report), EPA/600/R-05/043F. National Center for Environmental Assessment, NCEA, US Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • USEPA. (2009). Risk assessment guidance for superfund Volume I: Human health evaluation manual (Part F, Supplemental Guidance for Inhalation Risk Assessment), EPA-540-R-070-002, OSWER 9285.7-82, January 2009, Office of Superfund Remediation and Technology Innovation, Environmental Protection Agency Washington, DC.

    Google Scholar 

  • USEPA. (2000b). Supplementary guidance for conducting health risk assessment of chemical mixtures. U.S. Environmental Protection Agency, Washington, DC. EPA/630/R-00/002. August

    Google Scholar 

  • CEQ. (1989). Risk analysis: A guide to principles and methods for analyzing health and environmental risks, Council on Environmental Quality. Washington, D.C. NTIS: PB89-137772.

    Google Scholar 

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  1. Human Health Risk Assessment Practice, Washington, DC, USA

    Kofi Asante-Duah (Scientific Advisor/Environmental Consultant)

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  1. Kofi Asante-Duah
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Asante-Duah, K. (2017). Chemical Risk Characterization. In: Public Health Risk Assessment for Human Exposure to Chemicals. Environmental Pollution, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1039-6_11

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