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Gastric Cancer Prewarning and Early Diagnosis System pp 195–238Cite as

Multifunctional Nanoprobes for Theranostics of Gastric Cancer

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Part of the book series: Translational Medicine Research ((TRAMERE))

Abstract

Gastric cancer therapeutic strategies still focus on early diagnosis and operation therapy, enhanced immunotherapy, and killing gastric cancer stem cells to overcome multidrug resistance (MDR). This chapter summarizes that our team designed and prepared series of multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, including series of fluorescent magnetic nanoprobes, series of quantum dots nanoprobes and carbon dots, series of gold nanoprobes, series of upconversion nanoprobes, RNA nanoprobes, and nanoprobes for killing gastric cancer stem cells and enhanced immunotherapeutic efficacy. Up to date, carbon dots based nanoprobes were evaluated to confirm their safety, and were used for identifying the boundary of gastric cancer and tracking metastasis lymph nodes, exhibiting clinical application prospect.

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Acknowledgment

This work was supported by Chinese Key Basic Research Program (973 Project) (No. 2010CB933901 and 2015CB931802), the National Natural Scientific Foundation of China (Grant No. 81225010, 81327002, and 31170961), and 863 project of China (no. 2012AA022703 and 2014AA020700), Shanghai Science and Technology Fund (No. 13NM1401500).

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  1. Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument, National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China

    Daxiang Cui

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    Daxiang Cui

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Cui, D. (2017). Multifunctional Nanoprobes for Theranostics of Gastric Cancer. In: Cui, D. (eds) Gastric Cancer Prewarning and Early Diagnosis System. Translational Medicine Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-0951-2_11

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