Skip to main content

Amniotic Membrane in the Treatment of Burns

  • Chapter
Amniotic Membrane

Abstract

Burn wound dressing represents an important aspect of burn care. The various inherent features of amniotic membrane proved to be useful as it contributes towards the attributes of an ideal dressing. This biological dressing is inexpensive, able to enhance re-epithelialization, readily available and stored, hence rendering it suitable for a wide range of burn wound treatment. The different preparations of amniotic membrane provide additional benefit whereby clinicians can have a range of product to choose from. Pain relief, good wound adherence and conformability further increase the importance of amnion as burn wound dressing. The versatility and efficacy of the amnion makes it an attractive option despite of the enormous range commercially available wound management products in the market. This chapter presents a review of the various aspects of amniotic membrane for burn wound treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. WHO (2012) Burns – fact sheet. http://www.who.int/mediacentre/factsheets/fs365/en/

  2. ABA (2012) Burn incidence fact sheet. http://www.ameriburn.org/resources_factsheet.php

  3. Tyszkiewicz J, Uhrynowska-Tyszkiewicz I, Kaminski A, Dziedzic-Goclawska A (1999) Amnion allografts prepared in the central tissue bank in Warsaw. Ann Transplant 4:85–90

    CAS  PubMed  Google Scholar 

  4. Davis J (1910) Skin transplantation with a review of 550 cases at the Johns Hopkins hospital. Johns Hopkins Hosp Rep 15:307–395

    Google Scholar 

  5. Subrahmanyam M (1995) Amniotic membrane as a cover for microskin grafts. Br J Plast Surg 48:477–478

    Article  CAS  PubMed  Google Scholar 

  6. Ward D, Bennett J, Burgos H, Fabre J (1989) The healing of chronic venous leg ulcers with prepared human amnion. Br J Plast Surg 42:463–467

    Article  CAS  PubMed  Google Scholar 

  7. Gajiwala AL, Sharma V (2003) Use of irradiated amnion as a biological dressing in the treatment of radiation induced ulcers. Cell Tissue Bank 4:147–150

    Article  Google Scholar 

  8. Ravishanker R, Bath A, Roy R (2003) “Amnion Bank” – the use of long term glycerol preserved amniotic membranes in the management of superficial and superficial partial thickness burns. Burns 29:369–374

    Article  CAS  PubMed  Google Scholar 

  9. Mohammadi AA, Sabet B, Riazi H et al (2009) Human amniotic membrane dressing: an excellent method for outpatient management of burn wounds. Iran J Med Sci 34:61–64

    Google Scholar 

  10. Rao TV, Chandrasekharam V (1981) Use of dry human bovine amnion as a biological dressing. Arch Surg 116:891–896

    Article  CAS  PubMed  Google Scholar 

  11. Colocho G, Graham WP, Greene AE et al (1974) Human amniotic membrane as a physiologic wound dressing. Arch Surg 109:370–373

    Article  CAS  PubMed  Google Scholar 

  12. Burgos H, Sergeant R (1983) Lyophilized human amniotic membranes used in reconstruction of the ear. J R Soc Med 76:433

    CAS  PubMed Central  PubMed  Google Scholar 

  13. Adly O, Moghazy A, Abbas A et al (2010) Assessment of amniotic and polyurethane membrane dressings in the treatment of burns. Burns 36:703–710

    Article  CAS  PubMed  Google Scholar 

  14. Singh R, Chacharkar M (2011) Dried gamma-irradiated amniotic membrane as dressing in burn wound care. J Tissue Viability 20:49–54

    Article  PubMed  Google Scholar 

  15. Halim AS, Khoo TL, Yussof SJM (2010) Biologic and synthetic skin substitutes: an overview. Indian J Plast Surg 43:23–28

    Article  Google Scholar 

  16. Trelford J, Trelford-Sauder M (1979) The amnion in surgery, past and present. Am J Obstet Gynecol 134:833–845

    CAS  PubMed  Google Scholar 

  17. Matthews R, Faulk W, Bennett J (1982) A review of the role of amniotic membranes in surgical practice. Obstet Gynecol Ann 11:31–58

    CAS  Google Scholar 

  18. Talmi Y, Finkelstein Y, Zohar Y (1990) Use of human amniotic membrane as a biologic dressing. Eur J Plast Surg 13:160–162

    Article  Google Scholar 

  19. Unger M, Roberts M (1976) Lyophilized amniotic membranes on graft donor sites. Br J Plast Surg 29:99–101

    Article  CAS  PubMed  Google Scholar 

  20. Mostaque A, Rahman K (2011) Comparisons of the effects of biological membrane (amnion) and silver sulfadiazine in the management of burn wounds in children. J Burn Care Res 32:200–209

    Article  PubMed  Google Scholar 

  21. Bujang-Safawi E, Halim A, Khoo T, Dorai A (2010) Dried irradiated human amniotic membrane as a biological dressing for facial burns -a 7-year case series. Burns 36:876–882

    Article  CAS  PubMed  Google Scholar 

  22. Mohammadi AA, Mohammadi MK (2011) How does human amniotic membrane help major burn patients who need skin grafting: new experiences. In: Spear M (ed) Ski. grafts – Indic. Appl. Curr. Res. In Tech Europe, Rijeka, Croatia pp 265–276

    Google Scholar 

  23. Mohammadi AA, Johari HG, Eskandari S (2013) Effect of amniotic membrane on graft take in extremity burns. Burns 39:1137–1141

    Article  PubMed  Google Scholar 

  24. Barnea Y, Amir A, Leshem D et al (2004) Clinical comparative study of aquacel and paraffin gauze dressing for split-skin donor site treatment. Ann Plast Surg 53:132–136

    Article  PubMed  Google Scholar 

  25. Innes ME, Umraw N, Fish JS et al (2001) The use of silver coated dressings on donor site wounds: a prospective, controlled matched pair study. Burns 27:621–627

    Article  CAS  PubMed  Google Scholar 

  26. Losada F, García-Luna PP, Gómez-Cía T et al (2002) Effects of human recombinant growth hormone on donor-site healing in burned adults. World J Surg 26:2–8

    Article  PubMed  Google Scholar 

  27. Singh R, Kumar A, Singh D, Malviya A (2013) Use of gamma-irradiated amniotic membrane for the healing of split skin graft donor site. Tissue Eng Regen Med 10:110–114. doi:10.1007/s13770-013-0004-5

    Article  CAS  Google Scholar 

  28. Salehi SH, As’adi K, Mousavi SJ, Shoar S (2013) Evaluation of amniotic membrane effectiveness in skin graft donor site dressing in burn patients. Indian J Surg. doi:10.1007/s12262-013-0864-x. http://link.springer.com/search?query=Evaluation+of+Amniotic+Membrane+Effectiveness+in+Skin+Graft+Donor+Site+Dressing+in+Burn+Patients&search-within=Journal&facet-journal-id=12262#page-2. Published online 31 Jan 2013

  29. Fraser JF, Cuttle L, Kempf M et al (2009) A randomised controlled trial of amniotic membrane in the treatment of a standardised burn injury in the merino lamb. Burns 35:998–1003

    Article  PubMed  Google Scholar 

  30. Kirschbaum S, Hernandez H (1963) Use of amnion in extensive burns. In: 3rd International Congress in Plastic Surgery. Excerpta Medica, Amsterdam

    Google Scholar 

  31. Pigeon J (1960) Treatment of second-degree burns with amniotic membranes. Can Med Assoc J 83:844–845

    CAS  PubMed Central  PubMed  Google Scholar 

  32. Dino B, Eufemio G, De Villa M (1966) Human amnion: the establishment of an amnion bank and its practical application in surgery. J Philipp Med Assoc 42:357–366

    CAS  PubMed  Google Scholar 

  33. Sharma S, Bagree M, Bhat A et al (1985) Amniotic membrane is an affective burn dressing material. Jpn J Surg 15:140–143

    Article  CAS  PubMed  Google Scholar 

  34. Burleson R, Eiseman B (1972) Nature of the bond between partial-thickness skin and wound granulations. Surgery 72:315–322

    CAS  PubMed  Google Scholar 

  35. Niknejad H, Peirovi H, Jorjani M et al (2008) Properties of the amniotic membrane for potential use in tissue engineering. Eur Cell Mater 15:88–99

    CAS  PubMed  Google Scholar 

  36. Gump F, Kinney J (1970) Caloric and fluid losses through the burn wound. Surg Clin N Am 50:1235–1248

    CAS  PubMed  Google Scholar 

  37. Ghalambor A, Pipilzadeh MH, Khodadadi A (2000) The amniotic membrane: a suitable biological dressing to prevent infection in thermal burns. Med J Islam Acad Sci 13:115–118

    Google Scholar 

  38. Walker AB, Cooney DR, Allen JE (1977) Use of fresh amnion as a burn dressing. J Pediatr Surg 12:391–395

    Article  CAS  PubMed  Google Scholar 

  39. Miller T, Switzer W, Foley F, Moncrief J (1967) Early homografting of second degree burns. Plast Reconstr Surg 40:117–125

    Article  CAS  PubMed  Google Scholar 

  40. Robson M, Krizek T, Koss N, Samburg J (1973) Amniotic membranes as a temporary wound dressing. Surg Gynecol Obstet 136:904–906

    CAS  PubMed  Google Scholar 

  41. Bose B (1979) Burn wound dressing with human amniotic membrane. Ann R Coll Surg Engl 61:444–447

    CAS  PubMed Central  PubMed  Google Scholar 

  42. Bapat C, Kothary P (1974) Preliminary report on acceleration of wound healing by amnion membrane graft. Indian J Med Res 62:1342–1346

    CAS  PubMed  Google Scholar 

  43. Kim JS, Kim JC, Na BK et al (2000) Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn. Exp Eye Res 70:329–337

    Article  CAS  PubMed  Google Scholar 

  44. Faulk WP, Stevens PJ, Burgos H et al (1980) Human amnion as an adjunct in wound healing. Lancet 315:1156–1158

    Article  Google Scholar 

  45. Trelford J, Hanson F, Anderson D (1973) Amniotic membrane as a living surgical dressing in human patients. Oncology 28:358–364

    Article  CAS  PubMed  Google Scholar 

  46. Gruss JS, Jirsch DW (1978) Human amniotic membrane: a versatile wound dressing. Can Med Assoc J 118:1237–1246

    CAS  PubMed Central  PubMed  Google Scholar 

  47. Saymen DG, Nathan P, Holder IA et al (1973) Control of surface wound infection: skin versus synthetic grafts. Appl Microbiol 25:921–934

    CAS  PubMed Central  PubMed  Google Scholar 

  48. Burleson R, Eiseman B (1973) Mechanisms of antibacterial effect of biologic dressings. Ann Surg 177:181–186

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  49. Galask R, Snyder I (1970) Antimicrobial factors in amniotic fluid. Am J Obstet Gynecol 106:59–65

    CAS  PubMed  Google Scholar 

  50. Sachs B, Stern C (1979) Activity and characterization of a low molecular fraction present in human amniotic fluid with broad spectrum antibacterial activity. Br J Obstet Gynaecol 86:81–86

    Article  CAS  PubMed  Google Scholar 

  51. Faulk W, Galbraith GM (1979) Trophoblast transferrin and transferrin receptors in the host-parasite relationship of human pregnancy. Proc R Soc B Biol Sci 204:83–97

    Article  CAS  Google Scholar 

  52. McIntyre JA, Faulk WP (1979) Antigens of human trophoblast: effects of heterologous anti-trophoblast sera on lymphocyte responses in vitro. J Exp Med 149:824–836

    Article  CAS  PubMed  Google Scholar 

  53. Akle C, Adinolfi M, Welsh K et al (1981) Immunogenicity of human amniotic epithelial cells after transplantation into volunteers. Lancet 2:1003–1005

    Article  CAS  PubMed  Google Scholar 

  54. Dziedzic-Goclawska A (2000) The application of ionizing radiation to sterilise connective tissue allografts. In: Nather A, Yusof N, Hilmy N (eds) Radiation in tissue banking. World Scientific, Singapore, p 586

    Google Scholar 

  55. Singh R, Purohit S, Chacharkar M et al (2007) Microbiological safety and clinical efficacy of radiation sterilized amniotic membranes for treatment of second-degree burns. Burns 33:505–510

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ahmad Sukari Halim .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Halim, A.S., Bujang-Safawi, E., Saad, A.Z.M. (2015). Amniotic Membrane in the Treatment of Burns. In: Mamede, A., Botelho, M. (eds) Amniotic Membrane. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9975-1_7

Download citation

Publish with us

Policies and ethics