Skip to main content
  • 1162 Accesses

Abstract

Plague, also known as Black Death, is a natural focal disease caused by Yersinia pestis. It prevails in wild rodents, with rats as its important source of infection. Its pathogen is commonly carried by rat fleas to infect humans, which causes bubonic plague after its invasion of human skin and pneumonic plague after its invasion via the respiratory tract. Plague, one of the most serious infectious diseases threatening human life, has strong infectivity and a high mortality rate. In the Prevention and Control Act of Infectious Diseases in China, it has been listed as the first infectious disease in class A. Three pandemics of plague occurred, with the first event occurring in the sixth century which spread from Mediterranean into Europe and nearly 100 million deaths reported. The second pandemic occurred in the fourteenth century, with the disease prevailing in Europe, Asia, and African. The third pandemic occurred in the eighteenth century, with the disease prevailing in 32 countries. The pandemic in the fourteenth century involved China. Yersinia pestis can be manufactured into bioterrorism weapon to threaten the world peace. Therefore, the prevention and control of plague is very important.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • DaWa WJ, Pan WJ, Gu XY, et al. Primary pneumonic plague: report of 5 cases. Chin J Tuberc Respir Dis. 2011;34(6):404–8.

    Google Scholar 

  • Layton RC, Mega W, Mc Donald JD, et al. Levofloxacin cures experimental pneumonic plague in African green monkeys. PLoS Negl Trop Dis. 2011a;5(2):e959.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Layton RC, Brasel T, Gigliotti A, et al. Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation. J Med Primatol. 2011b;40(1):6–17.

    Article  PubMed  PubMed Central  Google Scholar 

Suggested Reading

  • Clark EA, Walker N, Ford DC, et al. Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from Yersinia pestis. J Biol Chem. 2011;286(27):24015–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cornelius CA, Quenee LE, Overheim KA, et al. Immunization with recombinant V10 Protects cynomolgus macaques from lethal pneumonic plague. Infect Immun. 2008;76(12):5588–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dutt AK, Akhtar R, Mcveigh M. Surat plague of 1994 re-examined[J]. Southeast Asian J Trop Med Public Health. 2006;37(4):755–60.

    PubMed  Google Scholar 

  • Gamble C, Jacobsen KO, Leffel E, et al. Use of a low-concentration heparin solution to extend the life of central venous catheters in African green monkeys (Chlorocebus aethiops). J Am Assoc Lab Anim Sci. 2007;46(3):58–60.

    CAS  PubMed  Google Scholar 

  • Hinnebusch BJ, Erickson DL. Yersinia pestis biofilm in the flea vector and its role in the transmission of plague. Curr Top Microbiol Immunol. 2008;322:229–48.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li LJ. Studies of infectious diseases. Beijing: Higher Education Press; 2011.

    Google Scholar 

  • Rossi CA, Ulrich M, Norris S, et al. Identification of a surrogate marker for infection in the African green monkey model of inhalation anthrax. Infect Immun. 2008;76(12):5790–801.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Smiley ST. Current challenges in the development of vaccines for pneumonic plague. Expert Rev Vaccines. 2008;7(2):209–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sun YC, Koumoutsi A, Darby C. The response regulator PhoP negatively regulator yersinia pseudotuberculosis and yersinia pestis biofilm. FEMS Microbiol Lett. 2009;290(1):85–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Van Andel R, Sherwood R, Gennings C, et al. Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestis. Comp Med. 2008;58(1):68–75.

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hong Jun Li .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media Dordrecht and People's Medical Publishing House

About this chapter

Cite this chapter

Li, R., Li, H.J., Wu, D. (2015). Plague. In: Li, H. (eds) Radiology of Infectious Diseases: Volume 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9876-1_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-9876-1_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-9875-4

  • Online ISBN: 978-94-017-9876-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics