Abstract
Plague, also known as Black Death, is a natural focal disease caused by Yersinia pestis. It prevails in wild rodents, with rats as its important source of infection. Its pathogen is commonly carried by rat fleas to infect humans, which causes bubonic plague after its invasion of human skin and pneumonic plague after its invasion via the respiratory tract. Plague, one of the most serious infectious diseases threatening human life, has strong infectivity and a high mortality rate. In the Prevention and Control Act of Infectious Diseases in China, it has been listed as the first infectious disease in class A. Three pandemics of plague occurred, with the first event occurring in the sixth century which spread from Mediterranean into Europe and nearly 100 million deaths reported. The second pandemic occurred in the fourteenth century, with the disease prevailing in Europe, Asia, and African. The third pandemic occurred in the eighteenth century, with the disease prevailing in 32 countries. The pandemic in the fourteenth century involved China. Yersinia pestis can be manufactured into bioterrorism weapon to threaten the world peace. Therefore, the prevention and control of plague is very important.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
DaWa WJ, Pan WJ, Gu XY, et al. Primary pneumonic plague: report of 5 cases. Chin J Tuberc Respir Dis. 2011;34(6):404–8.
Layton RC, Mega W, Mc Donald JD, et al. Levofloxacin cures experimental pneumonic plague in African green monkeys. PLoS Negl Trop Dis. 2011a;5(2):e959.
Layton RC, Brasel T, Gigliotti A, et al. Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation. J Med Primatol. 2011b;40(1):6–17.
Suggested Reading
Clark EA, Walker N, Ford DC, et al. Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from Yersinia pestis. J Biol Chem. 2011;286(27):24015–22.
Cornelius CA, Quenee LE, Overheim KA, et al. Immunization with recombinant V10 Protects cynomolgus macaques from lethal pneumonic plague. Infect Immun. 2008;76(12):5588–97.
Dutt AK, Akhtar R, Mcveigh M. Surat plague of 1994 re-examined[J]. Southeast Asian J Trop Med Public Health. 2006;37(4):755–60.
Gamble C, Jacobsen KO, Leffel E, et al. Use of a low-concentration heparin solution to extend the life of central venous catheters in African green monkeys (Chlorocebus aethiops). J Am Assoc Lab Anim Sci. 2007;46(3):58–60.
Hinnebusch BJ, Erickson DL. Yersinia pestis biofilm in the flea vector and its role in the transmission of plague. Curr Top Microbiol Immunol. 2008;322:229–48.
Li LJ. Studies of infectious diseases. Beijing: Higher Education Press; 2011.
Rossi CA, Ulrich M, Norris S, et al. Identification of a surrogate marker for infection in the African green monkey model of inhalation anthrax. Infect Immun. 2008;76(12):5790–801.
Smiley ST. Current challenges in the development of vaccines for pneumonic plague. Expert Rev Vaccines. 2008;7(2):209–21.
Sun YC, Koumoutsi A, Darby C. The response regulator PhoP negatively regulator yersinia pseudotuberculosis and yersinia pestis biofilm. FEMS Microbiol Lett. 2009;290(1):85–90.
Van Andel R, Sherwood R, Gennings C, et al. Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestis. Comp Med. 2008;58(1):68–75.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media Dordrecht and People's Medical Publishing House
About this chapter
Cite this chapter
Li, R., Li, H.J., Wu, D. (2015). Plague. In: Li, H. (eds) Radiology of Infectious Diseases: Volume 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9876-1_19
Download citation
DOI: https://doi.org/10.1007/978-94-017-9876-1_19
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-9875-4
Online ISBN: 978-94-017-9876-1
eBook Packages: MedicineMedicine (R0)