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Kinesins and Cancer pp 193–222Cite as

The Kinesin-6 Members MKLP1, MKLP2 and MPP1

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Abstract

The kinesin-6 or mitotic kinesin (MKLP) family comprises three members in human cells: MKLP1 (KIF23), MKLP2 (KIF20A), and MPP1 (KIF20B). All three members have been characterised primarily because of their role in cell division, where they contribute to the regulation of the cytokinetic machinery as cells exit mitosis. Here we discuss the mechanisms by which MKLP1, MKLP2 and MPP1 regulate events during cell division and in post-mitotic tissues, highlighting common themes and points of difference. We also outline the ways they are dysregulated in human cancers. Finally we discuss the different ways kinesin-6 family members are being targeted to develop novel chemotherapy and immunotherapy strategies for treating human cancers.

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Authors and Affiliations

  1. Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK

    Ryan D. Baron

  2. Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK

    Francis A. Barr

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  1. Chair, Department of Pharmaceutical and Biological Chemistry School of Pharmacy, University College London, London, United Kingdom

    Frank Kozielski, FSB

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Baron, R.D., Barr, F.A. (2015). The Kinesin-6 Members MKLP1, MKLP2 and MPP1. In: Kozielski, FSB, F. (eds) Kinesins and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9732-0_12

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