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Kinesins and Cancer pp 149–170Cite as

Kif14: A Clinically Relevant Kinesin and Potential Target for Cancer Therapy

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Abstract

Kinesin family member 14 (KIF14) is an atypical N-3 kinesin identified as a potential oncogene in the prototypic genetic cancer retinoblastoma. KIF14 is crucial for the last phases of cytokinesis, where it interacts with protein regulating cytokinesis 1 (PRC1), citron kinase (CIT) and supervillin to mediate formation of the cleavage furrow. However its importance in cancer is perhaps better characterized than its cell biology, and has generated much interest in this kinesin as a potential prognostic marker and exciting therapeutic target. Located on chromosome 1q32.1, a common region of gain in many cancers, KIF14 demonstrates genomic gain and overexpression in multiple neoplasms. KIF14 expression is tumor-specific, and in breast, lung, ovarian, liver, and brain cancers expression correlates with stage, aggressiveness and poor patient outcomes. In cancer cells, KIF14 interacts with tumorigenic signaling pathways that promote cellular behaviors such as adhesion, invasion and chemotherapeutic resistance, with the end result of promoting tumor progression. Here we discuss the mounting evidence pointing to KIF14 as a prognostic marker and oncogenic stimulus in multiple cancers, as well as the additional evidence required for validation of KIF14 as a potential drug target.

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Acknowledgments

We thank Brenda Gallie (Ontario Cancer Institute) for critical comments on the manuscript. Related work in the laboratory of TWC has been supported by an American Cancer Society Institutional Research Grant, the Knights Templar Eye Foundation and the Alcon Research Institute. This publication was also made possible in part by Grant Number KL2TR001106 from the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award and by an unrestricted grant from Research to Prevent Blindness, Inc.

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Authors and Affiliations

  1. Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Cancer Centre, Toronto, ON, Canada

    Brigitte L. Thériault

  2. Eugene and Marilyn Glick Eye Institute, Departments of Ophthalmology, Biochemistry and Molecular Biology, and Pharmacology and Toxicology, and Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA

    Timothy W. Corson

Authors
  1. Brigitte L. Thériault
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  2. Timothy W. Corson
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Correspondence to Timothy W. Corson .

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Editors and Affiliations

  1. Chair, Department of Pharmaceutical and Biological Chemistry School of Pharmacy, University College London, London, United Kingdom

    Frank Kozielski, FSB

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Thériault, B.L., Corson, T.W. (2015). Kif14: A Clinically Relevant Kinesin and Potential Target for Cancer Therapy. In: Kozielski, FSB, F. (eds) Kinesins and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9732-0_10

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