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Radioprotective Effect of CeO2 and GdEuVO4 Nanoparticles in “In Vivo” Experiments

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Nanoscience Advances in CBRN Agents Detection, Information and Energy Security

Abstract

In experiments performed in vivo of the irradiation of rats, a strong radioprotective effect of nanoparticles based on orthovanadates of rare earth elements and cerium dioxide was found. The nanoparticles were injected per os by two different schemes - once and during 15 days. For the 15-days scheme of GdEuVO4 nanoparticles injection the survival of animals irradiated with a dose of 6.0 Gy was 100 % during 30 days of observation. Injection of CeO2 nanoparticles also effectively protects the bodies of rats from radiation. For an irradiation with the lethal dose of 7.0 Gy, the radioprotective effect of the nanoparticles is negligible.

Note:

The work was conducted in accordance with international principles of the “European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes” (Strasbourg, 1986).

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Author information

Authors and Affiliations

  1. Grigoriev Institute for Medical Radiology-National Academy of Medical Science of Ukraine, 82 Pushkins’ka Street, Kharkiv, 61024, Ukraine

    E. M. Mamotyuk

  2. Institute for Scintillation Materials NAS of Ukraine, 60 Lenin ave., Kharkiv, 61001, Ukraine

    V. K. Klochkov, G. V. Grygorova, S. L. Yefimova & Yu. V. Malyukin

Authors
  1. E. M. Mamotyuk
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  2. V. K. Klochkov
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  3. G. V. Grygorova
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  4. S. L. Yefimova
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  5. Yu. V. Malyukin
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Corresponding author

Correspondence to G. V. Grygorova .

Editor information

Editors and Affiliations

  1. Department of Physics, University of Chemical Technology and Metallurgy, Sofia, Bulgaria

    Plamen Petkov

  2. Department of Physics, Technical University of Moldova, Chisinau, Moldova

    Dumitru Tsiulyanu

  3. Dept. of Mathematics and Natural Sciences, University of Kassel, Kassel, Germany

    Wilhelm Kulisch

  4. Inst. of Nanostructure Technologies and Analytics, University of Kassel, Kassel, Germany

    Cyril Popov

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Mamotyuk, E.M., Klochkov, V.K., Grygorova, G.V., Yefimova, S.L., Malyukin, Y.V. (2015). Radioprotective Effect of CeO2 and GdEuVO4 Nanoparticles in “In Vivo” Experiments. In: Petkov, P., Tsiulyanu, D., Kulisch, W., Popov, C. (eds) Nanoscience Advances in CBRN Agents Detection, Information and Energy Security. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9697-2_20

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