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Lycium Barbarum and Tumors in the Gastrointestinal Tract

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Lycium Barbarum and Human Health

Abstract

Chinese wolfberries have been proved to have an antitumor effect and to be less toxic. Lycium barbarum polysaccharide (LBP) isolated from aqueous extracts of L. barbarum has been identified as one of the major active ingredients that are responsible for the biological activities. LBP significantly affects the vascular endothelial growth factor (VEGF) and cyclin D1 protein expression in liver cancer. It inhibits gastric ulcer development and reduces the incidence of gastric cancer. Induction of cell-cycle arrest participates in the anticancer activity of LBP on gastric cancer cells. LBP has an antitumor effect probably by increasing the number of CD4 + T cells in tumor-infiltrating lymphocytes (TIL) to relieve the immunosuppression and enhance the antitumor function of the immune system. LBP inhibits the growth of colorectal tumor cells by inhibiting the expression of Livin and Bcl-2 and induces the apoptosis of tumor cells. LBP also has a long-term antiproliferative effect on colon cancer. These results provide a theoretical basis for the clinical use of Chinese wolfberries in the prevention and treatment of tumors in the gastrointestinal tract.

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Acknowledgments

This work was supported by the Student Innovation and Open Laboratory Program of Ningbo University (No. Cxxkf 2008-066), the Student Research and Innovation Program of Ningbo University (2008), the Scientific Innovation Team Project of Ningbo (No. 2011B82014), the Project of Key Disciplines in Ningbo (No. XKL11D2127 and No. XKL11D2128), the Foundation of Zhejiang Provincial Key Laboratory of Pathophysiology (No. 201301), and the K. C. Wong Magna Fund in Ningbo University.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, and Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, 315211, Ningbo, People’s Republic of China

    Peifei Li, Bingxiu Xiao & Junming Guo

  2. Ningbo College of Health Sciences, 315104, Ningbo, People’s Republic of China

    Huilin Chen

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  1. Peifei Li
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  2. Bingxiu Xiao
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  3. Huilin Chen
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  4. Junming Guo
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Correspondence to Junming Guo .

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Editors and Affiliations

  1. Department of Anatomy, LKS Faculty of Medicine the University of Hong Kong, Hong Kong, China

    Raymond Chuen-Chung Chang

  2. Department of Anatomy, LKS Faculty of Medicine the University of Hong Kong, Hong Kong, China

    Kwok-Fai So

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Li, P., Xiao, B., Chen, H., Guo, J. (2015). Lycium Barbarum and Tumors in the Gastrointestinal Tract. In: Chang, RC., So, KF. (eds) Lycium Barbarum and Human Health. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9658-3_6

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  • DOI: https://doi.org/10.1007/978-94-017-9658-3_6

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  • Publisher Name: Springer, Dordrecht

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  • Online ISBN: 978-94-017-9658-3

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