Abstract
This chapter provides an evolutionary mode in the field of Cancer epigenetic and it was aimed to bridge between different chapters. Epigenetic as a Reservoir in cancer open diverse avenues including fundamental, diagnostics, preventive and therapeutic aspects. Three new insights as the multi-potential and multi-directional models are provided including ‘a map of Cancer Development’, ‘Epigenetic Programming’, and ‘Diverse- methylation process, target and function at different ages’. These models are indicative of capability and cooperative manner of epigenetics in Science and Medicine. In addition, different aspects of 16 provided chapters have been presented at a glance. Finally, I tried to provide a new insight in the field of Evolutionary Epigenetic as two new terms including ‘Medical Epi-anthropology’ and ‘Cancer Epi-anthropology’. Through these directions, exploring about our ancestral lines and origin of the malignant and non- cancerous would be possible. By considering the importance of translational paradigm and pharmacogenetics, epigenetic is a reliable choice in cancer drug innovation. Besides, the impact of other genetic and cellular alterations as a challenging item in cancer therapy is highlighted. The final message is ‘considering epigenetic alteration by application of the complementary maneuvering through the cellular/molecular platforms to achieve the most effective therapeutic mélange’.
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Abbreviations
- ATM::
-
Ataxia-telangiectasia mutated gene
- ATO::
-
Arsenic trioxide
- BC::
-
Breast cancer
- BPP::
-
Beneficial preventive programming
- CTCs::
-
Circulating TUMOR cells
- DI::
-
Diverse impact
- DF::
-
Diverse function
- DIn::
-
Diverse interaction
- DC::
-
Diverse cell territories
- DA::
-
Different ages
- DP::
-
Developmental process
- EP::
-
Embryonic programming
- FP::
-
Fetal programming
- EP::
-
Environmental programming
- EF::
-
Environmental factors
- ED::
-
Embryonic development
- FD::
-
Fetal development
- FTC::
-
Follicular thyroid cancer
- GBEF::
-
Genetic based environmental factors
- 14-3-3σ::
-
Human mammary epithelium-specific marker 1 (HME1)
- HEF::
-
Hazard environmental factors
- PNP::
-
Pre-natal programming
- P/N-PP::
-
Positive/negative preventive programming
- PND::
-
Pre-natal development Pos-ND: Post-natal development
- RASSF1A::
-
Ras association domain family 1A gene
- SCZ: :
-
Schizophrenia
References
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Mehdipour, P. (2015). Essence of Cancer Epigenetic: A Harmonic Art for the Future. In: Mehdipour, P. (eds) Epigenetics Territory and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9639-2_17
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DOI: https://doi.org/10.1007/978-94-017-9639-2_17
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