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Essence of Cancer Epigenetic: A Harmonic Art for the Future

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Epigenetics Territory and Cancer
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Abstract

This chapter provides an evolutionary mode in the field of Cancer epigenetic and it was aimed to bridge between different chapters. Epigenetic as a Reservoir in cancer open diverse avenues including fundamental, diagnostics, preventive and therapeutic aspects. Three new insights as the multi-potential and multi-directional models are provided including ‘a map of Cancer Development,Epigenetic Programming’, and ‘Diverse- methylation process, target and function at different ages. These models are indicative of capability and cooperative manner of epigenetics in Science and Medicine. In addition, different aspects of 16 provided chapters have been presented at a glance. Finally, I tried to provide a new insight in the field of Evolutionary Epigenetic as two new terms including ‘Medical Epi-anthropology’ and ‘Cancer Epi-anthropology. Through these directions, exploring about our ancestral lines and origin of the malignant and non- cancerous would be possible. By considering the importance of translational paradigm and pharmacogenetics, epigenetic is a reliable choice in cancer drug innovation. Besides, the impact of other genetic and cellular alterations as a challenging item in cancer therapy is highlighted. The final message is ‘considering epigenetic alteration by application of the complementary maneuvering through the cellular/molecular platforms to achieve the most effective therapeutic mélange’.

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Abbreviations

ATM::

Ataxia-telangiectasia mutated gene

ATO::

Arsenic trioxide

BC::

Breast cancer

BPP::

Beneficial preventive programming

CTCs::

Circulating TUMOR cells

DI::

Diverse impact

DF::

Diverse function

DIn::

Diverse interaction

DC::

Diverse cell territories

DA::

Different ages

DP::

Developmental process

EP::

Embryonic programming

FP::

Fetal programming

EP::

Environmental programming

EF::

Environmental factors

ED::

Embryonic development

FD::

Fetal development

FTC::

Follicular thyroid cancer

GBEF::

Genetic based environmental factors

14-3-3σ::

Human mammary epithelium-specific marker 1 (HME1)

HEF::

Hazard environmental factors

PNP::

Pre-natal programming

P/N-PP::

Positive/negative preventive programming

PND::

Pre-natal development Pos-ND: Post-natal development

RASSF1A::

Ras association domain family 1A gene

SCZ: :

Schizophrenia

References

  • Gokhman D, Lavi E, Prüfer K, Fraga MF, Riancho JA, Kelso J, Pääbo S, Meshorer E, Carmel L (2014) Reconstructing the DNA methylation maps of the Neandertal and the Denisovan. Science 344:523–527

    Article  CAS  PubMed  Google Scholar 

  • Gray SG (2014) Book review: “Epigenetics”. Front Genet 5:104. doi:10.3389/fgene.2014.00104 (Lyle A (Ed) Epigenetics. Garland Sci. Taylor & Francis Group, LLC)

    Article  PubMed Central  Google Scholar 

  • Heerboth S, Lapinska K, Snyder N, Leary M, Rollinson S, Sarkar S (2014) Use of epigenetic drugs in disease. An overview. Genet Epigenetics 6:9–19. doi:10.4137/GEG.S12270

    CAS  Google Scholar 

  • Lyon MF (1974) Mechanisms and evolutionary origins of variable X-chromosome activity in mammals. Proc R Soc Lond B 187:243–268

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Parvin Mehdipour .

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Mehdipour, P. (2015). Essence of Cancer Epigenetic: A Harmonic Art for the Future. In: Mehdipour, P. (eds) Epigenetics Territory and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9639-2_17

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