Skip to main content

Neuroimaging in Psychiatry

  • Chapter
  • First Online:
Book cover Neurosurgical Treatments for Psychiatric Disorders
  • 1184 Accesses

Abstract

Psychiatric disorders are generally defined by a combination of how a person feels, behaves, thinks, or perceives. The disorders may be associated with particular brain regions or functional units or with the nervous system as a whole, and are often diagnosed within a particular social context. In the past few decades, neuroimaging modalities have been developed to investigate specific brain regions thought to be involved in particular disorders. Neuroimaging has been applied in the differential diagnosis of neuropsychiatric syndromes and disorders, especially in otherwise difficult clinical contexts. Neuroimaging methodologies can also provide information about neural mechanisms and abnormal neural circuitry involved in various psychiatric disorders. Additionally, neuroimaging is an important tool for drug discovery and development.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Perlini C, Bellani M, Brambilla P. Structural imaging techniques in schizophrenia. Acta Psychiatr Scand. 2012;126(4):235–42.

    Article  CAS  PubMed  Google Scholar 

  2. Narayanaswamy JC, Venkatasubramanian G, Gangadhar BN. Neuroimaging studies in schizophrenia: an overview of research from Asia. Int Rev Psychiatry. 2012;24(5):405–16.

    Article  PubMed  Google Scholar 

  3. Sun D, et al. Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms. Biol Psychiatry. 2009;66(11):1055–60.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Meisenzahl EM, et al. Structural brain alterations at different stages of schizophrenia: a voxel-based morphometric study. Schizophr Res. 2008;104(1–3):44–60.

    Article  CAS  PubMed  Google Scholar 

  5. Hu M, et al. Decreased left middle temporal gyrus volume in antipsychotic drug-naive, first-episode schizophrenia patients and their healthy unaffected siblings. Schizophr Res. 2013;144(1–3):37–42.

    Article  PubMed  Google Scholar 

  6. Thompson PM, et al. Time-lapse mapping of cortical changes in schizophrenia with different treatments. Cereb Cortex. 2009;19(5):1107–23.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Xiao Y, et al. Similar and different gray matter deficits in schizophrenia patients and their unaffected biological relatives. Front Psychiatry. 2013;4:150.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Vago DR, et al. Identification of neural targets for the treatment of psychiatric disorders: the role of functional neuroimaging. Neurosurg Clin N Am. 2011;22(2):279–305.

    Google Scholar 

  9. Sorg C, et al. Increased intrinsic brain activity in the striatum reflects symptom dimensions in schizophrenia. Schizophr Bull. 2013;39(2):387–95.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Ebisch SJ, et al. Altered brain long-range functional interactions underlying the link between aberrant self-experience and self-other relationship in first-episode schizophrenia. Schizophr Bull. 2013.

    Google Scholar 

  11. Tu PC, et al. Schizophrenia and the brain’s control network: aberrant within- and between-network connectivity of the frontoparietal network in schizophrenia. Schizophr Res. 2013;147(2–3):339–47.

    Article  PubMed  Google Scholar 

  12. Mou X, et al. Voice recognition and altered connectivity in schizophrenic patients with auditory hallucinations. Prog Neuropsychopharmacol Biol Psychiatry. 2013;44:265–70.

    Article  PubMed  Google Scholar 

  13. Zanelli J, et al. Neuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relatives. Psychiatry Res. 2009;168(3):193–7.

    Article  PubMed  Google Scholar 

  14. Eisenberg DP, et al. Executive function, neural circuitry, and genetic mechanisms in schizophrenia. Neuropsychopharmacology. 2010;35(1):258−77.

    Google Scholar 

  15. Blasi G, et al. Nonlinear response of the anterior cingulate and prefrontal cortex in schizophrenia as a function of variable attentional control. Cereb Cortex. 2010;20(4):837−45.

    Google Scholar 

  16. Masdeu JC. Neuroimaging in psychiatric disorders. Neurotherapeutics. 2011;8(1):93–102.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Fusar-Poli P, Meyer-Lindenberg A. Striatal presynaptic dopamine in schizophrenia, part II: meta-analysis of [(18)F/(11)C]-DOPA PET studies. Schizophr Bull. 2013;39(1):33–42.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Fusar-Poli P, Meyer-Lindenberg A. Striatal presynaptic dopamine in schizophrenia, Part I: meta-analysis of dopamine active transporter (DAT) density. Schizophr Bull. 2013;39(1):22–32.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Brunelin J, Fecteau S, Suaud-Chagny MF. Abnormal striatal dopamine transmission in schizophrenia. Curr Med Chem. 2013;20(3):397–404.

    CAS  PubMed Central  PubMed  Google Scholar 

  20. Lerond J, et al. Effects of aripiprazole, risperidone, and olanzapine on 5-HT1A receptors in patients with schizophrenia. J Clin Psychopharmacol. 2013;33(1):84–9.

    Article  CAS  PubMed  Google Scholar 

  21. Kang JI, et al. Reduced binding potential of GABA-A/benzodiazepine receptors in individuals at ultra-high risk for psychosis: an [18F]-fluoroflumazenil positron emission tomography study. Schizophr Bull. 2013.

    Google Scholar 

  22. Poels EM, et al. Imaging glutamate in schizophrenia: review of findings and implications for drug discovery. Mol Psychiatry. 2014;19(1):20–9.

    Article  CAS  PubMed  Google Scholar 

  23. Clark CP, Frank LR, Brown GG. Sleep deprivation, EEG, and functional MRI in depression: preliminary results. Neuropsychopharmacology. 2001;25(5 Suppl):S79–84.

    Article  CAS  PubMed  Google Scholar 

  24. Clark CP, et al. Improved anatomic delineation of the antidepressant response to partial sleep deprivation in medial frontal cortex using perfusion-weighted functional MRI. Psychiatry Res. 2006;146(3):213–22.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Clark CP, et al. Does amygdalar perfusion correlate with antidepressant response to partial sleep deprivation in major depression? Psychiatry Res. 2006;146(1):43–51.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Meyer JH, et al. Imaging the serotonin transporter during major depressive disorder and antidepressant treatment. J Psychiatry Neurosci. 2007;32:86–102.

    Google Scholar 

  27. Theberge J. Perfusion magnetic resonance imaging in psychiatry. Top Magn Reson Imaging. 2008;19(2):111–30.

    Article  PubMed  Google Scholar 

  28. Meyer JH, et al. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am J Psychiatry. 2004;161(5):826–35.

    Article  PubMed  Google Scholar 

  29. Frokjaer VG, et al. High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding. Neuroimage. 2009;46(2):360–6.

    Article  PubMed  Google Scholar 

  30. Sublette ME, et al. Regional brain glucose uptake distinguishes suicide attempters from non-attempters in major depression. Arch Suicide Res. 2013;17(4):434–47.

    Article  PubMed  Google Scholar 

  31. Schienle A, Ebner F, Schafer A. Localized gray matter volume abnormalities in generalized anxiety disorder. Eur Arch Psychiatry Clin Neurosci. 2011;261(4):303–7.

    Article  PubMed  Google Scholar 

  32. Freitas-Ferrari MC, et al. Neuroimaging in social anxiety disorder: a systematic review of the literature. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(4):565–80.

    Article  PubMed  Google Scholar 

  33. Nakao T, et al. fMRI of patients with social anxiety disorder during a social situation task. Neurosci Res. 2011;69(1):67–72.

    Article  PubMed  Google Scholar 

  34. Ayling E, et al. Diffusion tensor imaging in anxiety disorders. Curr Psychiatry Rep. 2012;14(3):197–202.

    Article  PubMed  Google Scholar 

  35. Jones T, Rabiner EA. The development, past achievements, and future directions of brain PET. J Cereb Blood Flow Metab. 2012;32(7):1426–54.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  36. Frank GK, Kaye WH. Current status of functional imaging in eating disorders. Int J Eat Disord. 2012;45(6):723–36.

    Article  PubMed  Google Scholar 

  37. Phan KL, et al. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage. 2002;16(2):331–48.

    Article  PubMed  Google Scholar 

  38. Critchley HD, Mathias CJ, Dolan RJ. Fear conditioning in humans: the influence of awareness and autonomic arousal on functional neuroanatomy. Neuron. 2002;33(4):653–63.

    Article  CAS  PubMed  Google Scholar 

  39. Uher R, et al. Functional neuroanatomy of body shape perception in healthy and eating-disordered women. Biol Psychiatry. 2005;58(12):990–7.

    Article  PubMed  Google Scholar 

  40. Zhang HW, et al. Metabolic imaging of deep brain stimulation in anorexia nervosa: a 18F-FDG PET/CT study. Clin Nucl Med. 2013;38(12):943−8.

    Google Scholar 

  41. Audenaert K, et al. Decreased 5-HT2a receptor binding in patients with anorexia nervosa. J Nucl Med. 2003;44(2):163–9.

    CAS  PubMed  Google Scholar 

  42. Bailer UF, et al. Serotonin transporter binding after recovery from eating disorders. Psychopharmacology. 2007;195(3):315–24.

    Article  CAS  PubMed  Google Scholar 

  43. Chen XL, et al. MR perfusion-weighted imaging and quantitative analysis of cerebral hemodynamics with symptom provocation in unmedicated patients with obsessive-compulsive disorder. Neurosci Lett. 2004;370(2–3):206–11.

    Article  CAS  PubMed  Google Scholar 

  44. Zuo ct, et al. Metabolic imaging of bilateral anterior capsulotomy in refractory obsessive compulsive disorder: an FDG PET study. J Cereb Blood Flow Metab. 2013;33(6):880−7.

    Google Scholar 

  45. Ballanger B, et al. PET functional imaging of deep brain stimulation in movement disorders and psychiatry. J Cereb Blood Flow Metab. 2009;29(11):1743–54.

    Article  PubMed  Google Scholar 

  46. Bunevicius A, et al. Brain lesions manifesting as psychiatric disorders: eight cases. CNS Spectr. 2008;13(11):950–8.

    PubMed  Google Scholar 

  47. Wong DF, Tauscher J, Grunder G. The role of imaging in proof of concept for CNS drug discovery and development. Neuropsychopharmacology. 2009;34(1):187–203.

    Article  CAS  PubMed  Google Scholar 

  48. Grunder G, et al. The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia. Neuropsychopharmacology. 2006;31(5):1027–35.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chuantao Zuo .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Shanghai Jiao Tong University Press, Shanghai and Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Zuo, C., Zhang, H. (2015). Neuroimaging in Psychiatry. In: Sun, B., Salles, A. (eds) Neurosurgical Treatments for Psychiatric Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9576-0_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-9576-0_3

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-9575-3

  • Online ISBN: 978-94-017-9576-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics