Abstract
Drug addiction is also known as drug dependence. A committee of experts from WHO defined drug addiction as a mental, and sometimes a physical, state caused by the interaction of the drug with the organism. Individuals addicted to a drug exhibit a compulsive and continuous drug-taking behavior along with other reactions. The aim of these reactions is either to experience euphoria or to avoid the discomfort caused by drug withdrawal. The core feature of addiction is that the addicts know that the behavior is pernicious but they cannot control their intake. Drug addiction includes two parts, physiological dependence (physical dependence) and psychological dependence (psychic dependence). Physiological dependence is a physiological adaptation state caused by repeated drug consumption and displays drug tolerance and withdrawal syndrome. Psychological dependence is the euphoria caused by drug consumption and underlies the need for continuous consumption to experience the euphoria repeatedly. It is the main cause for relapse into drug addiction.
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References
Dieckmann G, Schneider H. Influence of stereotactic hypothalamotomy on alcohol and drug addiction. Appl Neurophysiol. 1978;41(1–4):93–8.
Jansson B, Nystrom S. Lobotomy as a therapeutic alternative in drug addiction. Lakartidningen. 1968;65(24):2444–5.
Kanaka TS, Balasubramaniam V. Stereotactic cingulumotomy for drug addiction. Appl Neurophysiol. 1978;41(1–4):86–92.
Medvedev SV, Anichkov AD, Polyakov YI. Physiological mechanisms of the effectiveness of bilateral stereotactic cingulotomy against strong psychological dependence in drug addicts. Hum Physiol. 2003;29(4):492–7.
Gao G, Wang X, He S, et al. Clinical study for alleviating opiate drug psychological dependence by a method of ablating the nucleus accumbens with stereotactic surgery. Stereotact Funct Neurosurg. 2003;81(1–4):96–104.
Wang X, He S, Heng L et al. Follow-up of nucleus accumbens lesion for treatment of drug dependence. Chinese Journal of Neurosurgery. 2005;10.28;21(10).
Fu X, Niu C. Stereotactic and Functional Neurosurgery Anhui Science and Technology Publishing House. 2004
Xu M, Wang C, Jiang C. Bilateral cingulotomy for the treatment of heroin dependence. Chinese Journal of Minimally Invasive Neurosurgery. 2005;10(4):162–3.
Yang K, Xi S, Wang K et al. Stereotactic bilateral nucleus accumbens lesion for the treatment of opioid dependence. Chinese Journal of Stereotactic and Functional Neurosurgery. 2005;18(3):135–9.
Orellana C. Controversy over brain surgery for heroin addiction in Russia. Lancet Neurol. 2002;1(6):333.
Everitt BJ, Robbins TW. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci. 2005;8(11):1481–9.
Belin D, Everitt BJ. Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron. 2008;57(3):432–41.
Kalivas PW, McFarland K. Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology. 2003;168(1–2):44–56.
Bittar RG, Kar-Purkayastha I, Owen SL, et al. Deep brain stimulation for pain relief: a meta-analysis. J Clin Neurosci: Official J Neurosurg Soc Australas. 2005;12(5):515–9.
Wichmann T, Delong MR. Deep brain stimulation for neurologic and neuropsychiatric disorders. Neuron. 2006;52(1):197–204.
Yamamoto T, Katayama Y. Deep brain stimulation therapy for the vegetative state. Neuropsychological Rehabil. 2005;15(3–4):406–13.
Zhou H, Xu J, Jiang J. Deep brain stimulation of nucleus accumbens on heroin-seeking behaviors: a case report. Biol Psychiatry. 2011;69:e41–2.
Li N, Wang J, Wang XL, Chang CW, Ge SN, Gao L, et al. Nucleus accumbens surgery for addiction. World Neurosurg. 2012. pii:S1878–8750(12)01106–0, doi:10.1016/j.wneu.2012.10.007.
Greenberg BD, Gabriels LA, Malone DA Jr, Rezai AR, Friehs GM, Okun MS, et al. Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience. Mol Psychiatry. 2010;15(1):64–79.
Anderson D, Ahmed A. Treatment of patients with intractable obsessive-compulsive disorder with anterior capsular stimulation: case report. J Neurosurg. 2003;98:1104–8.
Schaltenbrand G, Wahren W. Atlas for stereotaxy of the human brain. Stuttgard: Thieme; 1977.
Heng L, Wang X, He S, et al. Complications of nucleus accumbens leasions for the treatment of drug dependence. Chinese Journal of Stereotactic and Functional Neurosurgery. 2006;19(1):5–8.
Hang J. Reflections on neurosurgery detoxification. Chinese Journal of Pain Medicine. 2005;11(1):45–6.
Qu X, Qiu Z. Our views for the treatment of drug addiction by neurosurgery. Medicine and Philosophy. 2004;25(12):32.
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© 2015 Shanghai Jiao Tong University Press, Shanghai and Springer Science+Business Media Dordrecht
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Gao, G., Wang, X. (2015). Stereotactic Neurosurgery for Drug Addiction. In: Sun, B., Salles, A. (eds) Neurosurgical Treatments for Psychiatric Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9576-0_14
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DOI: https://doi.org/10.1007/978-94-017-9576-0_14
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