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Neurosurgical Treatments for Psychiatric Disorders pp 113–123Cite as

DBS for Obsessive-Compulsive Disorder

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Abstract

According to Diagnostic and Statistical Manual of Mental disorders, fifth edition (DSM-V), Obsessive compulsive disorder (OCD) is characterized by persistent obsessions with intrusive thoughts leading to severe generalized anxiety and/or compulsions in the form of repetitive tasks to relieve this distress. OCD is often associated with depression and other co-morbidities. There is also an increase in the incidence of suicidal ideation and suicide among patients with OCD. OCD is a chronic and severe disabling heterogeneous disorder that has a significant impact on the life of patients and their families with public health consequences. It affects approximately 2–3 % of population in the United States and worldwide and is the 10th leading cause of disability worldwide. OCD affects both genders equally. Pharmacological [Selective Serotonin reuptake inhibitors (SSRIs)] and non-pharmacological therapies such as cognitive behavior therapy (CBT) are the first line treatment options in patients with medical refractory OCD. These modalities are effective in approximately 50 % of patients with 40–60 % reduction in OCD symptoms. However, 10–25 % of these refractory patients have persistent OCD symptoms despite aggressive pharmacotherapy and behavior therapy.

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Abbreviations

DBS:

Deep brain stimulation

OCD:

Obsessive-compulsive disorder

Y-BOCS:

Yale-Brown obsessive compulsive scale

fMRI:

Functional magnetic resonance imaging

PET:

Positron emission tomography

NAcc:

Nucleus accumbens

STN:

Subthalamic nucleus

ALIC:

Anterior limb of internal capsule

Vc/Vs:

Ventral capsule and ventral striatum

ITP:

Inferior thalamic peduncle

Gpi:

Globus pallidus internus

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Author information

Authors and Affiliations

  1. Center of Neuromodulation, Wexner Medical Center, The Ohio State University, 410 W 10th Ave, Room 1047, Columbus, OH, 43210, USA

    Mayur Sharma

  2. Department of Neurosurgery, Center of Neuromodulation, Wexner Medical Center, The Ohio State University, 480 Medical Center Drive, Columbus, OH, 43210, USA

    Emam Saleh & Milind Deogaonkar

  3. Neuroscience Program and Center for Neuromodulation, Wexner Medical Center, The Ohio State University, 480 Medical Center Drive, Columbus, OH, 43210, USA

    Ali Rezai

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  1. Mayur Sharma
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Correspondence to Ali Rezai .

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Editors and Affiliations

  1. Center for Functional Neurosurgery, Ruijin Hospital Shanghai Jiao Tong University, Shanghai, China

    Bomin Sun

  2. Neurosurgery, University of California, Los Angeles, California, USA

    Antonio De Salles

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Sharma, M., Saleh, E., Deogaonkar, M., Rezai, A. (2015). DBS for Obsessive-Compulsive Disorder. In: Sun, B., Salles, A. (eds) Neurosurgical Treatments for Psychiatric Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9576-0_11

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