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Applications of Peptide Retention Time in Proteomic Data Analysis

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Urine Proteomics in Kidney Disease Biomarker Discovery

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 845))

Abstract

In proteomic studies, liquid chromatography is commonly used to separate peptide mixtures prior to mass spectrometry (MS) detection. As an independent dimension of information from the information provided by the MS, peptide retention time information has been proven to be able to aid proteomic data analysis in many aspects. So far, some popular software has offered options for this information for MS data acquisition and analysis. This chapter is a brief review of current methodologies of retention time prediction and application in proteomic analysis.

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Authors and Affiliations

  1. National Key Laboratory of Medical Molecular Biology, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 5 Dong Dan San Tiao, Beijing, China

    Chen Shao

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  1. Chen Shao
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Correspondence to Chen Shao .

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Editors and Affiliations

  1. Pathophysiology, Peking Union Medical College & Inst. Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, China

    Youhe Gao

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Shao, C. (2015). Applications of Peptide Retention Time in Proteomic Data Analysis. In: Gao, Y. (eds) Urine Proteomics in Kidney Disease Biomarker Discovery. Advances in Experimental Medicine and Biology, vol 845. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9523-4_7

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