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Urinary Proteins with Post-translational Modifications

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Urine Proteomics in Kidney Disease Biomarker Discovery

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 845))

Abstract

Research on the human urine proteome may lay the foundation for the discovery of relevant disease biomarkers. Posttranslational modifications (PTMs) have important effects on the functions of protein biomarkers. Identifying PTMs without enrichment adds no extra steps to conventional identification procedures for urine proteomics. The only difference is that this method requires software that can conduct unrestrictive identifications of PTMs. These PTMs include methylation, dehydration, oxidation, hydroxylation, phosphorylation, or dihydroxylation. These data are useful reference for PTM biomarker discovery in the future.

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Author information

Authors and Affiliations

  1. Key Laboratory of Medical Molecular Biology, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/School of Basic Medicine, 5 Dong Dan San Tiao, Beijing, China

    Liu Liu

  2. Department of Nephrology, Beijing Anzhen Hospital, Capital Medical University, 2 Road, Chaoyang District, Beijing, China

    Xuejiao Liu

  3. Department of Nephrology, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Dongcheng District, Beijing, China

    Xuejiao Liu

Authors
  1. Liu Liu
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  2. Xuejiao Liu
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Corresponding author

Correspondence to Liu Liu .

Editor information

Editors and Affiliations

  1. Pathophysiology, Peking Union Medical College & Inst. Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, China

    Youhe Gao

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Liu, L., Liu, X. (2015). Urinary Proteins with Post-translational Modifications. In: Gao, Y. (eds) Urine Proteomics in Kidney Disease Biomarker Discovery. Advances in Experimental Medicine and Biology, vol 845. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9523-4_6

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