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Effects of Diuretics on Urinary Proteins

  • Xundou LiEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 845)

Abstract

Biomarker is the measurable change associated with a physiological or pathophysiological process. Unlike blood which has mechanisms to keep the internal environment homeostatic, urine is more likely to reflect changes of the body. As a result, urine is likely to be a better biomarker source than blood. However, since the urinary proteome is affected by many factors, including diuretics, careful evaluation of those effects is necessary if urinary proteomics is used for biomarker discovery. The human orthologs of most of these 14 proteins affected are stable in the healthy human urinary proteome, and 10 of them are reported as disease biomarkers. Thus, our results suggest that the effects of diuretics deserve more attention in future urinary protein biomarker studies. Moreover, the distinct effects of diuretics on the urinary proteome may provide clues to the mechanisms of diuretics.

Keywords

Diuretics Urine proteome 

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.National Key Laboratory of Medical Molecular Biology, Department of Pathophysiology, Institute of Basic Medical SciencesChinese Academy of Medical Sciences/School of Basic MedicineBeijingChina

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