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Effects of Exercise on the Urinary Proteome

  • Maxie Kohler
  • Wilhelm Schänzer
  • Mario ThevisEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 845)

Abstract

Exercise-induced proteinuria has been observed and studied for more than a century. It was found that different sport disciplines alter the urinary proteome in different ways. Moderate-intensity exercise results in increased glomerular filtration, meaning that medium-sized proteins are excreted in higher amounts, while high-intensity exercise of short duration also increases the excretion of low molecular weight proteins as a result of tubular dysfunction. Exhaustive exercise may lead to the excretion of hemoglobin or myoglobin, which changes the urinary proteome considerably. Studies comparing protein maps of different sport types compared to a control group showed that quality and quantity of urinary proteins are interindividually different. In addition, urine samples collected before and after exercise exhibit substantially different protein patterns even from the same person. Therefore, further studies investigating the urinary proteome are desirable. As the variation of protein content and composition in urine are generally much higher than in other matrices, respective studies need to be well controlled and homogenous groups of volunteers should be chosen. In addition to the sport-related physiological and biochemical interest, exercise-induced protein changes also need to be considered for biomarker measurements from urine samples for kidney or other diseases.

Keywords

Urinary proteome Exercise Biomarker Kidney diseases 

Notes

Acknowledgments

The study was conducted with support of the Manfred-Donike-Institute, Cologne, Germany, and Antidoping Switzerland, Berne, Switzerland.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Maxie Kohler
    • 1
    • 2
  • Wilhelm Schänzer
    • 1
  • Mario Thevis
    • 1
    Email author
  1. 1.Institute of Biochemistry/Center for Preventive Doping ResearchGerman Sport University CologneCologneGermany
  2. 2.Chemistry DepartmentUniversity of CologneCologneGermany

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