Hormone-Dependent Changes in Female Urinary Proteome

  • Annalisa Castagna
  • Sarath Kiran Channavajjhala
  • Francesca Pizzolo
  • Oliviero OlivieriEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 845)


Human urine represents a good source for proteomic research for clinically related studies as it can be collected and processed easily and can give information about kidney-related mechanisms. Little is known about the urinary proteomic changes resulting from physiological (normal), pathological, or environmental variations, and there are few reports on hormone-related modifications of urine proteome. In our study, we highlighted the variations of urinary proteins associated with menstrual cycle or estro-progestin pill in females. We also described an association between some urinary proteins and the renin–angiotensin–aldosterone system, which might help to improve the understanding of physiological and pathological processes when a gender-specific pattern such as the menopause-related hypertension or eclampsia is evident. We therefore support the usefulness of urinary proteomics as a valuable tool for clinically related study as it can provide information on candidate biomarkers which, in turn, need to be confirmed by multiple approaches before the use in a clinical setting.


Urinary proteomics Female hormones Hypertension Renin–angiotensin–aldosterone system 


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Annalisa Castagna
    • 1
  • Sarath Kiran Channavajjhala
    • 1
  • Francesca Pizzolo
    • 1
  • Oliviero Olivieri
    • 1
    Email author
  1. 1.Department of Medicine, Unit of Internal MedicineUniversity of VeronaVeronaItaly

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