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Evolution of the Urinary Proteome During Human Renal Development and Maturation

  • Zi Wang
  • Mingxi LiEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 845)

Abstract

Renal development process in human is divided into 3 successive stages: pronephros, mesonephros, and metanephros. The tubules continue to mature for 1–2 year after birth. Research of urinary proteome during human renal development is still lacking. Most urine proteome studies focus on postnatal renal maturation period. A comparison between full-term infant and adult urinary protein pattern identified 648 infant-enriched protein spots, of which most were involved in cellular turnover and metabolism. The study of preterm infant urinary proteome compared with term infants suggests elevated IGFBP-1, IGFBP-2, and IGFBP-6, monocyte chemotactic protein-1, CD14, and sialic acid-binding Ig-like lectin 5 during nephrogenesis. Research in several congenital kidney and urinary tract anomalies, ureteropelvic junction obstruction and autosomal dominant polycystic kidney disease, has discovered novel biomarkers, which may help to imply the mechanisms underlying inherited disorders. Future exploration of urinary proteome evolution during renal maturation is needed and will help to find novel biomarkers specially suiting pediatric renal diseases.

Keywords

Renal development Urinary proteome Biomarkers Ureteropelvic junction obstruction Autosomal dominant polycystic kidney disease 

References

  1. 1.
    Arant BS Jr (1978) Developmental patterns of renal functional maturation compared in the human neonate. J Pediatrics 92:705–712Google Scholar
  2. 2.
    Bakun M, Niemczyk M, Domanski D, Jazwiec R, Perzanowska A, Niemczyk S, Kistowski M, Fabijanska A, Borowiec A, Paczek L, Dadlez M (2012) Urine proteome of autosomal dominant polycystic kidney disease patients. Clin Proteomics 9:13PubMedCrossRefPubMedCentralGoogle Scholar
  3. 3.
    Baum M, Quigley R, Satlin L (2003) Maturational changes in renal tubular transport. Curr Opin Nephrol Hypertens 12:521–526Google Scholar
  4. 4.
    Charlton JR, Norwood VF, Kiley SC, Gurka MJ, Chevalier RL (2012) Evolution of the urinary proteome during human renal development and maturation: variations with gestational and postnatal age. Pediatr Res 72:179–185Google Scholar
  5. 5.
    Doublier S, Amri K, Seurin D, Moreau E, Merlet-Benichou C, Striker GE, Gilbert T (2001) Overexpression of human insulin-like growth factor binding protein-1 in the mouse leads to nephron deficit. Pediatr Res 49:660–666Google Scholar
  6. 6.
    Eskild-Jensen A, Frokiaer J, Djurhuus JC, Jorgensen TM, Nyengaard JR (2002) Reduced number of glomeruli in kidneys with neonatally induced partial ureteropelvic obstruction in pigs. J Urol 167:1435–1439Google Scholar
  7. 7.
    Froehlich JW, Vaezzadeh AR, Kirchner M, Briscoe AC, Hofmann O, Hide W, Steen H, Lee RS (2013). An in-depth comparison of the male pediatric and adult urinary proteomes. Biochimica et biophysica acta 1844:1044–1050Google Scholar
  8. 8.
    Hoy WE, Douglas-Denton RN, Hughson MD, Cass A, Johnson K, Bertram JF (2003) A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int Suppl 63:S31–37Google Scholar
  9. 9.
    Kistler AD, Mischak H, Poster D, Dakna M, Wuthrich RP, Serra AL (2009) Identification of a unique urinary biomarker profile in patients with autosomal dominant polycystic kidney disease. Kidney Int 76:89–96Google Scholar
  10. 10.
    Lee RS, Monigatti F, Lutchman M, Patterson T, Budnik B, Steen JA, Freeman MR, Steen H (2008) Temporal variations of the postnatal rat urinary proteome as a reflection of systemic maturation. Proteomics 8:1097–1112PubMedCrossRefGoogle Scholar
  11. 11.
    Madsen MG, Norregaard R, Frokiaer J, Jorgensen TM (2011) Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis. J Pediatr Urol 7:105–112Google Scholar
  12. 12.
    Maezawa Y, Kreidberg J, Quaggin SE (2012) Embryology of the Kidney. In Brenner and Rector’s the Kidney (9th Edition). Elseiver, New York, pp 1–23Google Scholar
  13. 13.
    Mesrobian HG, Mirza SP (2012) Hydronephrosis: a view from the inside. Pediatr Clin North Am 59:839–851 Google Scholar
  14. 14.
    Mesrobian HG, Mitchell ME, See WA, Halligan BD, Carlson BE, Greene AS, Wakim BT (2010) Candidate urinary biomarker discovery in ureteropelvic junction obstruction: a proteomic approach. J Urol 184:709–714Google Scholar
  15. 15.
    Michos O (2009). Kidney development: from ureteric bud formation to branching morphogenesis. Curr Opin Genet Dev 19:484–490Google Scholar
  16. 16.
    Osathanondh V, Potter EL (1963) Development of Human Kidney as Shown by Microdissection. III. Formation and Interrelationship of Collecting Tubules and Nephrons. Archives Pathol 76:290–302Google Scholar
  17. 17.
    Ravine D, Gibson RN, Walker RG, Sheffield LJ, Kincaid-Smith P, Danks DM (1994) Evaluation of ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease 1. Lancet 343:824–827PubMedCrossRefGoogle Scholar
  18. 18.
    Saxen L (1987) Organogenesis of the kidney. Cambridge University Press, CambridgeCrossRefGoogle Scholar
  19. 19.
    Wen JG, Ringgaard S, Jorgensen TM, Stodkilde-Jorgensen H, Djurhuus JC, Frokiaer J (2002) Long-term effects of partial unilateral ureteral obstruction on renal hemodynamics and morphology in newborn rats: a magnetic resonance imaging study. Urol Res 30:205–212Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Department of Nephrology, Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina

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