Abstract
Ever since synthetic biology as a formal discipline was launched, several parts, devices and circuits have been designed. The story of engineering-inspired approach to biology probably started from a publication in 2000 that described three gene circuit called repressilator and another one describing toggle switch. While repressilator is given a more detailed chapter in another chapter, this chapter provides a brief overview of key technical innovations in synthetic biology.
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References
Fraser CM et al (1995) The minimal gene complement of Mycoplasma genitalium. Science 270:397–403
Gardner TS, Cantor CC, Collins JJ (2000) Construction of a genetic toggle switch in Escherichia coli. Nature 403:339–342
Gibson DG et al (2010) Chemical synthesis of the mouse mitochondrial genome. Nat Methods 7(11):901–913
Gibson DG et al (2010) Creation of a bacterial cell controlled by a chemically synthesized genome. Science 329:52–56
Karas BJ et al (2013) Direct transfer of whole genomes from bacteria to yeast. Nat Methods 10:410–412
Luisi PL (2006) The emergence of life—from chemical origins to synthetic biology. Cambridge University Press, Cambridge
Acknowledgements
I would like to thank Ms. Nafisa Bulsara, Mr. Shivananda Naikar and Ms. Snehal Kamble for their useful inputs.
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© 2015 Springer Science+Business Media Dordrecht
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Dhar, P. (2015). Engineering Biological Systems: A Brief Overview. In: Singh, V., Dhar, P. (eds) Systems and Synthetic Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9514-2_21
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DOI: https://doi.org/10.1007/978-94-017-9514-2_21
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