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Metabolic Engineering of Microorganisms for Biosynthesis of Antibiotics

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Systems and Synthetic Biology

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Abstract

Number of microorganisms produces antibiotics that can inhibit or kill the other microbes. The production of some antibiotics is not sufficient in native host rather difficult to synthesize chemically and to extract in large amounts for commercialization. Metabolic engineering plays an increasingly significant role in the production of antibiotics and its precursors. Thus, we engineer biosynthetic pathways in desire host for the production of sufficient quantity of antibiotics. In this chapter, we illustrated bioengineering of different microbes using synthetic biology and metabolic engineering approaches for production and regulation of antibiotics.

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Acknowledgements

Authors wish to thank A.K. Singh, Satya Prakash and Pritee Singh for providing the suggestions, encouragement and fruitful discussion during preparation of this chapter.

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Authors and Affiliations

  1. Synth-Bio Group, Institute of Systems & Synthetic Biology, University of Evry, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbruères, 91030, ÉVRY, France

    Vijai Singh

  2. National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, 226002, Lucknow, India

    Indra Mani

  3. Department of Biochemistry, Faculty of Science, Banaras Hindu University, 221005, Varanasi, India

    Indra Mani & Dharmendra Kumar Chaudhary

Authors
  1. Vijai Singh
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  2. Indra Mani
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  3. Dharmendra Kumar Chaudhary
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Correspondence to Vijai Singh .

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Editors and Affiliations

  1. Centre for Computational Biology and Bioinformatics, Central University of Himachal Pradesh, Dharamshala, India

    Vikram Singh

  2. Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Gautam Budh Nagar, India

    Pawan K. Dhar

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Singh, V., Mani, I., Chaudhary, D. (2015). Metabolic Engineering of Microorganisms for Biosynthesis of Antibiotics. In: Singh, V., Dhar, P. (eds) Systems and Synthetic Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9514-2_18

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