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West Nile Virus: From Africa to Europe, America, and Beyond

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Zoonoses - Infections Affecting Humans and Animals

Abstract

Since the mid-1990s, West Nile virus (WNV) outbreaks of increased severity first appeared in Africa, then in Europe, and finally in North America. These outbreaks were due to related lineage one viruses of apparent pathogenicity. More recently lineage 2 strains also of apparent increased pathogenicity have caused outbreaks in Europe. Some of the implicated lineage 1 strains and the lineage 2 strains have a mutation in the NS3 helicase gene, which confers increased viral pathogenesis in birds. The recent pattern of sporadic cases and outbreaks of WNV that has emerged in Europe and North America shows no signs of abating. While broad areas of high risk can be identified, the sporadic, local and regional outbreaks that occur within these areas remain elusively unpredictable. Fewer than one percent of persons infected develop neuroinvasive disease, characterized by meningitis, encephalitis, or acute flaccid paralysis. Increasing age is a risk factor for neuroinvasive disease, both in humans and horses. Four WNV vaccines are currently marketed for horses and clinical trials have been conducted for two human vaccines. Treatment is supportive.

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References

  • Adrian Diaz L, Komar N, Visintin A, Dantur Juri MJ, Stein M, Lobo Allende R, Spinsanti L, Konigheim B, Aguilar J, Laurito M, Almiron W, Contigiani M (2008) West Nile virus in birds, Argentina. Emerg Infect Dis 14(4):689–691

    PubMed  Google Scholar 

  • Alpert SG, Fergerson J, Noel LP (2003) Intrauterine West Nile virus: ocular and systemic findings. Am J Ophthalmol 136(4):733–735

    PubMed  Google Scholar 

  • Anastasiadou A, Economopoulou A, Kakoulidis I, Zilidou R, Butel D, Zorpidou D, Ferentinos G, Markou P, Kougas E, Papa A (2011) Non-neuroinvasive West Nile virus infections during the outbreak in Greece. Clin Microbiol Infect 17(11):1681–1683

    CAS  PubMed  Google Scholar 

  • Anastasiadou A, Kakoulidis I, Butel D, Kehagia E, Papa A (2013) Follow-up study of Greek patients with West Nile virus neuroinvasive disease. Int J Infect Dis 17(7):e494–497

    PubMed  Google Scholar 

  • Anderson JF, Main AJ (2006) Importance of vertical and horizontal transmission of West Nile virus by Culex pipiens in the Northeastern United States. J Infect Dis 194(11):1577–1579

    PubMed  Google Scholar 

  • Anderson RC, Horn KB, Hoang MP, Gottlieb E, Bennin B (2004) Punctate exanthem of West Nile Virus infection: report of 3 cases. J Am Acad Dermatol 51(5):820–823

    PubMed  Google Scholar 

  • Andreadis TG (2012) The contribution of Culex pipiens complex mosquitoes to transmission and persistence of West Nile virus in North America. J Am Mosq Control Assoc 28(4 Suppl):137–151

    PubMed  Google Scholar 

  • Andreadis TG, Armstrong PM (2007) A two-year evaluation of elevated canopy trapping for Culex mosquitoes and West Nile virus in an operational surveillance program in the northeastern United States. J Am Mosq Control Assoc 23(2):137–148

    PubMed  Google Scholar 

  • Andreadis TG, Anderson JF, Vossbrinck CR, Main AJ (2004) Epidemiology of West Nile virus in Connecticut: a five-year analysis of mosquito data 1999–2003. Vector Borne Zoonotic Dis 4(4):360–378

    PubMed  Google Scholar 

  • Appler KK, Brown AN, Stewart BS, Behr MJ, Demarest VL, Wong SJ, Bernard KA (2010) Persistence of West Nile virus in the central nervous system and periphery of mice. PLoS ONE 5(5):e10649

    PubMed Central  PubMed  Google Scholar 

  • Austgen, LE, Bowen RA, Bunning ML, Davis BS, Mitchell CJ, Chang GJ (2004) Experimental infection of cats and dogs with West Nile virus. Emerg Infect Dis 10(1):82–86

    PubMed Central  PubMed  Google Scholar 

  • Autorino, GL, Battisti A, Deubel V, Ferrari G, Forletta R, Giovannini A, Lelli R, Murri S, Scicluna MT (2002) West Nile virus epidemic in horses, Tuscany region, Italy. Emerg Infect Dis 8(12):1372–1378

    PubMed Central  PubMed  Google Scholar 

  • Bai F, Kong KF, Dai J, Qian F, Zhang L, Brown CR, Fikrig E, Montgomery RR (2010) A paradoxical role for neutrophils in the pathogenesis of West Nile virus. J Infect Dis 202(12):1804–1812

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bakonyi T, Ivanics E, Erdelyi K, Ursu K, Ferenczi E, Weissenbock H, Nowotny N (2006) Lineage 1 and 2 strains of encephalitic West Nile virus, central Europe. Emerg Infect Dis 12(4):618–623

    PubMed Central  PubMed  Google Scholar 

  • Bakonyi T, Ferenczi E, Erdelyi K, Kutasi O, Csorgo T, Seidel B, Weissenbock H, Brugger K, Ban E, Nowotny N (2013) Explosive spread of a neuroinvasive lineage 2 West Nile virus in Central Europe, 2008/2009. Vet Microbiol 165(1–2):61–70

    PubMed  Google Scholar 

  • Banet-Noach C, Simanov L, Malkinson M (2003) Direct (non-vector) transmission of West Nile virus in geese. Avian Pathology 32(5):489–494

    PubMed  Google Scholar 

  • Barzon L, Pacenti M, Franchin E, Lavezzo E, Martello T, Squarzon L, Toppo S, Fiorin F, Marchiori G, Russo F, Cattai M, Cusinato R, Palu G (2012a) New endemic West Nile virus lineage 1a in northern Italy, July 2012. Euro Surveill 17(31):pii=20231

    Google Scholar 

  • Barzon L, Pacenti M, Franchin E, Martello T, Lavezzo E, Squarzon L, Toppo S, Fiorin F, Marchiori G, Scotton GP, Russo F, Cattai M, Cusinato R, Palu G (2012b) Clinical and virological findings in the ongoing outbreak of West Nile virus Livenza strain in northern Italy, July to September 2012. Euro Surveill 17(36):20260

    Google Scholar 

  • Barzon L, Pacenti M, Franchin E, Squarzon L, Lavezzo E, Toppo S, Martello T, Cattai M, Cusinato R, Palu G (2012c) Novel West Nile virus lineage 1a full genome sequences from human cases of infection in north-eastern Italy, 2011. Clin Microbiol Infect 18(12):E541–544

    Google Scholar 

  • Barzon L, Pacenti M, Franchin E, Pagni S, Martello T, Cattai M, Cusinato R, Palu G (2013a) Excretion of West Nile virus in urine during acute infection. J Infect Dis 208(7):1086–1092

    Google Scholar 

  • Barzon L, Papa A, Pacenti M, Franchin E, Lavezzo E, Squarzon L, Masi G, Martello T, Testa T, Cusinato R, Palu G (2013b) Genome sequencing of West Nile virus from human cases in Greece, 2012. Viruses 5(9):2311–2319

    Google Scholar 

  • Baty SA, Gibney KB, Staples JE, Patterson AB, Levy C, Lehman J, Wadleigh T, Feld J, Lanciotti R, Nugent CT, Fischer M (2012) Evaluation for West Nile virus (WNV) RNA in urine of patients within 5 months of WNV infection. J Infect Dis 205(9):1476–1477

    PubMed  Google Scholar 

  • Beasley DW (2011) Vaccines and immunotherapeutics for the prevention and treatment of infections with West Nile virus. Immunotherapy 3(2):269–285

    CAS  PubMed  Google Scholar 

  • Benson TJ, Ward MP, Lampman RL, Raim A, Weatherhead PJ (2012) Implications of spatial patterns of roosting and movements of american robins for West Nile virus transmission. Vector Borne Zoonotic Dis 12(10):877–885

    PubMed  Google Scholar 

  • Berg PJ, Smallfield S, Svien L (2010) An investigation of depression and fatigue post West Nile virus infection. S D Med 63(4):127–129, 131–123

    PubMed  Google Scholar 

  • Bernkopf H, Levine S, Nerson R (1953) Isolation of West Nile virus in Israel. J Infect Dis 93(3):207–218

    CAS  PubMed  Google Scholar 

  • Biedenbender R, Bevilacqua J, Gregg AM, Watson M, Dayan G (2011) Phase II, randomized, double-blind, placebo-controlled, multicenter study to investigate the immunogenicity and safety of a West Nile virus vaccine in healthy adults. J Infect Dis 203(1):75–84

    CAS  PubMed Central  PubMed  Google Scholar 

  • Biggerstaff, BJ, Petersen LR (2003) Estimated risk of transmission of the West Nile virus through blood transfusion in the US, 2002. Transfusion 43(8):1007–1017

    PubMed  Google Scholar 

  • Blackburn NK, Reyers F, Berry WL, Shepherd AJ (1989) Susceptibility of dogs to West Nile virus: a survey and pathogenicity trial. J Comp Pathol 100(1):59–66

    CAS  PubMed  Google Scholar 

  • Blitvich BJ, Bowen RA, Marlenee NL, Hall RA, Bunning ML, Beaty BJ (2003) Epitope-blocking enzyme-linked immunosorbent assays for detection of west Nile virus antibodies in domestic mammals. J Clin Microbiol 41(6):2676–2679

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bode AV, Sejvar JJ, Pape WJ, Campbell GL, Marfin AA (2006) West Nile virus disease: a descriptive study of 228 patients hospitalized in a 4-county region of Colorado in 2003. Clin Infect Dis 42(9):1234–1240

    PubMed  Google Scholar 

  • Bondre VP, Jadi RS, Mishra AC, Yergolkar PN, Arankalle VA (2007) West Nile virus isolates from India: evidence for a distinct genetic lineage. J Gen Virol 88(Pt 3):875–884

    CAS  PubMed  Google Scholar 

  • Bosch I, Herrera F, Navarro JC, Lentino M, Dupuis A, Maffei J, Jones M, Fernandez E, Perez N, Perez-Eman J, Guimaraes AE, Barrera R, Valero N, Ruiz J, Velasquez G, Martinez J, Comach G, Komar N, Spielman A, Kramer L (2007) West Nile virus, Venezuela. Emerg Infect Dis 13(4):651–653

    PubMed Central  PubMed  Google Scholar 

  • Bowden SE, Magori K, Drake JM (2011) Regional differences in the association between land cover and West Nile virus disease incidence in humans in the United States. Am J Trop Med Hyg 84(2):234–238

    PubMed Central  PubMed  Google Scholar 

  • Brault AC, Huang CY, Langevin SA, Kinney RM, Bowen RA, Ramey WN, Panella NA, Holmes EC, Powers AM, Miller BR (2007) A single positively selected West Nile viral mutation confers increased virogenesis in American crows. Nat Genet 39(9):1162–1166

    CAS  PubMed Central  PubMed  Google Scholar 

  • Brown JA, Factor DL, Tkachenko N, Templeton SM, Crall ND, Pape WJ, Bauer MJ, Ambruso DR, Dickey WC, Marfin AA (2007) West Nile viremic blood donors and risk factors for subsequent West Nile fever. Vector Borne Zoonotic Dis 7(4):479–488

    PubMed  Google Scholar 

  • Bunning ML, Bowen RA, Cropp CB, Sullivan KG, Davis BS, Komar N, Godsey MS, Baker D, Hettler DL, Holmes DA, Biggerstaff BJ, Mitchell CJ (2002) Experimental infection of horses with West Nile virus. Emerg Infect Dis 8(4):380–386

    PubMed Central  PubMed  Google Scholar 

  • Burton JM, Kern RZ, Halliday W, Mikulis D, Brunton J, Fearon M, Pepperell C, Jaigobin C (2004) Neurological manifestations of West Nile virus infection. Can J Neurol Sci 31(2):185–193

    PubMed  Google Scholar 

  • Busch MP, Kleinman SH, Tobler LH, Kamel HT, Norris PJ, Walsh I, Matud JL, Prince HE, Lanciotti RS, Wright DJ, Linnen JM, Caglioti S (2008) Virus and antibody dynamics in acute West Nile virus infection. J Infect Dis 198(7):984–993

    CAS  PubMed  Google Scholar 

  • Cabre O, Grandadam M, Marie JL, Gravier P, Prange A, Santinelli Y, Rous V, Bourry O, Durand JP, Tolou H, Davoust B (2006) West Nile Virus in horses, sub-Saharan Africa. Emerg Infect Dis 12(12):1958–1960

    PubMed Central  PubMed  Google Scholar 

  • Calisher CH (1988) Antigenic classification and taxonomy of flaviviruses (family Flaviviridae) emphasizing a universal system for the taxonomy of viruses causing tick-borne encephalitis. Acta Virol 32(5):469–478

    CAS  PubMed  Google Scholar 

  • Cantile C, Di Guardo G, Eleni C, Arispici M (2000) Clinical and neuropathological features of West Nile virus equine encephalomyelitis in Italy. Equine Vet J 32(1):31–35

    CAS  PubMed  Google Scholar 

  • Cantile C, Del Piero F, Di Guardo G, Arispici M (2001) Pathologic and immunohistochemical findings in naturally occuring West Nile virus infection in horses. Vet Pathol 38(4):414–421

    CAS  PubMed  Google Scholar 

  • Carney RM, Husted S, Jean C, Glaser C, Kramer V (2008) Efficacy of aerial spraying of mosquito adulticide in reducing incidence of West Nile Virus, California, 2005. Emerg Infect Dis 14(5):747–754

    PubMed Central  PubMed  Google Scholar 

  • Carson PJ, Konewko P, Wold KS, Mariani P, Goli S, Bergloff P, Crosby RD (2006) Long-term clinical and neuropsychological outcomes of West Nile virus infection. Clin Infect Dis 43(6):723–730

    PubMed  Google Scholar 

  • Carson PJ, Borchardt SM, Custer B, Prince HE, Dunn-Williams J, Winkelman V, Tobler LH, Biggerstaff BJ, Lanciotti R, Petersen LR, Busch MP (2012) Neuroinvasive disease and West Nile virus infection, North Dakota, USA, 1999–2008. Emerg Infect Dis 18(4):684–686

    PubMed Central  PubMed  Google Scholar 

  • Centers for Disease Control and Prevention (2002a) Intrauterine West Nile virus infection–New York, 2002. MMWR Morb Mortal Wkly Rep 51(50):1135–1136

    Google Scholar 

  • Centers for Disease Control and Prevention (2002b) Laboratory-acquired West Nile virus infections–United States, 2002. MMWR Morb Mortal Wkly Rep 51(50):1133–1135

    Google Scholar 

  • Centers for Disease Control and Prevention (2003) West Nile virus infection among turkey breeder farm workers–Wisconsin, 2002. MMWR Morb Mortal Wkly Rep 52(42):1017–1019

    Google Scholar 

  • Centers for Disease Control and Prevention (2004) Possible dialysis-related west nile virus transmission–Georgia, 2003. MMWR Morb Mortal Wkly Rep 53(32):738–739

    Google Scholar 

  • Centers for Disease Control and Prevention (2005) Human exposure to mosquito-control pesticides–Mississippi, North Carolina, and Virginia, 2002 and 2003. MMWR Morb Mortal Wkly Rep 54(21):529–532

    Google Scholar 

  • Centers for Disease Control and Prevention (2007) West Nile virus transmission through blood transfusion–South Dakota, 2006. MMWR Morb Mortal Wkly Rep 56(4):76–79

    Google Scholar 

  • Centers for Disease Control and Prevention (2013) Fatal West Nile virus infection after probable transfusion-associated transmission–Colorado, 2012. MMWR Morb Mortal Wkly Rep 62(31):622–624

    Google Scholar 

  • Centers for Disease Control and Prevention. West Nile virus transmission. http://www.cdc.gov/westnile/transmission/. Accessed 7 Jan 2014

  • Chambers TJ, Hahn CS, Galler R, Rice CM (1990) Flavivirus genome organization, expression, and replication. Annu Rev Microbiol 44:649–688

    CAS  PubMed  Google Scholar 

  • Chevalier V, Lancelot R, Diaite A, Mondet B, Sall B, De Lamballerie X (2006) Serological assessment of West Nile fever virus activity in the pastoral system of Ferlo, Senegal. Ann N Y Acad Sci 1081:216–225

    PubMed  Google Scholar 

  • Chevalier V, Dupressoir A, Tran A, Diop OM, Gottland C, Diallo M, Etter E, Ndiaye M, Grosbois V, Dia M, Gaidet N, Sall AA, Soti V, Niang M (2010) Environmental risk factors of West Nile virus infection of horses in the Senegal River basin. Epidemiol Infect 138(11):1601–1609

    CAS  PubMed  Google Scholar 

  • Chinikar S, Javadi A, Ataei B, Shakeri H, Moradi M, Mostafavi E, Ghiasi SM (2012) Detection of West Nile virus genome and specific antibodies in Iranian encephalitis patients. Epidemiol Infect 140(8):1525–1529

    CAS  PubMed  Google Scholar 

  • Chinikar S, Shah-Hosseini N, Mostafavi E, Moradi M, Khakifirouz S, Jalali T, Goya MM, Shirzadi MR, Zainali M, Fooks AR (2013) Seroprevalence of West Nile virus in Iran. Vector Borne Zoonotic Dis 13(8):586–589

    PubMed  Google Scholar 

  • Cho H, Diamond MS (2012) Immune responses to West Nile virus infection in the central nervous system. Viruses 4(12):3812–3830

    PubMed Central  PubMed  Google Scholar 

  • Chowers MY, Lang R, Nassar F, Ben-David D, Giladi M, Rubinshtein E, Itzhaki A, Mishal J, Siegman-Igra Y, Kitzes R, Pick N, Landau Z, Wolf D, Bin H, Mendelson E, Pitlik SD, Weinberger M (2001) Clinical characteristics of the West Nile fever outbreak, Israel, 2000. Emerg Infect Dis 7(4):675–678

    CAS  PubMed Central  PubMed  Google Scholar 

  • Chung WM, Buseman CM, Joyner SN, Hughes SM, Fomby TB, Luby JP, Haley RW (2013) The 2012 West Nile encephalitis epidemic in Dallas, Texas. JAMA 310(3):297–307

    CAS  PubMed  Google Scholar 

  • Ciccozzi M, Peletto S, Cella E, Giovanetti M, Lai A, Gabanelli E, Acutis PL, Modesto P, Rezza G, Platonov AE, Lo Presti A, Zehender G (2013) Epidemiological history and phylogeography of West Nile virus lineage 2. Infect Genet Evol 17:46–50

    PubMed  Google Scholar 

  • Cook RL, Xu X, Yablonsky EJ, Sakata N, Tripp JH, Hess R, Piazza P, Rinaldo CR (2010) Demographic and clinical factors associated with persistent symptoms after West Nile virus infection. Am J Trop Med Hyg 83(5):1133–1136

    PubMed Central  PubMed  Google Scholar 

  • Cornel AJ, Jupp PG, Blackburn NK (1993) Environmental temperature on the vector competence of Culex univittatus (Diptera: Culicidae) for West Nile virus. J Med Entomol 30(2):449–456

    CAS  PubMed  Google Scholar 

  • Crowder DW, Dykstra EA, Brauner JM, Duffy A, Reed C, Martin E, Peterson W, Carriere Y, Dutilleul P, Owen JP (2013) West Nile virus prevalence across landscapes is mediated by local effects of agriculture on vector and host communities. PLoS One 8(1):e55006

    CAS  PubMed Central  PubMed  Google Scholar 

  • Darwish MA, Ibrahim AH (1971) Survey for antibodies to arboviruses in Egyptian sera. I. West Nile virus antihemagglutinins in human and animal sera. J Egypt Public Health Assoc 46(2):61–70

    CAS  PubMed  Google Scholar 

  • Davis BS, Chang GJ, Cropp B, Roehrig JT, Martin DA, Mitchell CJ, Bowen R, Bunning ML (2001) West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays. J Virol 75(9):4040–4047

    CAS  PubMed Central  PubMed  Google Scholar 

  • Davis CT, Ebel GD, Lanciotti RS, Brault AC, Guzman H, Siirin M, Lambert A, Parsons RE, Beasley DW, Novak RJ, Elizondo-Quiroga D, Green EN, Young DS, Stark LM, Drebot MA, Artsob H, Tesh RB, Kramer LD, Barrett AD (2005) Phylogenetic analysis of North American West Nile virus isolates, 2001–2004: evidence for the emergence of a dominant genotype. Virology 342(2):252–265

    CAS  PubMed  Google Scholar 

  • Dayan GH, Bevilacqua J, Coleman D, Buldo A, Risi G (2012) Phase II, dose ranging study of the safety and immunogenicity of single dose West Nile vaccine in healthy adults > 50 years of age. Vaccine 30(47):6656–6664

    CAS  PubMed  Google Scholar 

  • De Filette M, Ulbert S, Diamond M, Sanders NN (2012) Recent progress in West Nile virus diagnosis and vaccination. Vet Res 43(1):16

    PubMed Central  PubMed  Google Scholar 

  • DeGroote JP, Sugumaran R (2012) National and regional associations between human West Nile virus incidence and demographic, landscape, and land use conditions in the coterminous United States. Vector Borne Zoonotic Dis 12(8):657–665

    PubMed  Google Scholar 

  • Del Giudice P, Schuffenecker I, Vandenbos F, Counillon E, Zeller H (2004) Human West Nile virus, France. Emerg Infect Dis 10(10):1885–1886

    PubMed Central  PubMed  Google Scholar 

  • Del Giudice P, Schuffenecker I, Zeller H, Grelier M, Vandenbos F, Dellamonica P, Counillon E (2005) Skin manifestations of West Nile virus infection. Dermatology 211(4):348–350

    CAS  PubMed  Google Scholar 

  • Depoortere E, Kavle J, Keus K, Zeller H, Murri S, Legros D (2004) Outbreak of West Nile virus causing severe neurological involvement in children, Nuba Mountains, Sudan, 2002. Trop Med Int Health 9(6):730–736

    PubMed  Google Scholar 

  • Diamond MS (2009) Progress on the development of therapeutics against West Nile virus. Antiviral Res 83(3):214–227

    CAS  PubMed Central  PubMed  Google Scholar 

  • Diuk-Wasser MA, Molaei G, Simpson JE, Folsom-O’Keefe CM, Armstrong PM, Andreadis TG (2010) Avian communal roosts as amplification foci for West Nile virus in urban areas in northeastern United States. Am J Trop Med Hyg 82(2):337–343

    PubMed Central  PubMed  Google Scholar 

  • Dohm DJ, ML O’Guinn, Turell MJ (2002) Effect of environmental temperature on the ability of Culex pipiens (Diptera: Culicidae) to transmit West Nile virus. J Med Entomol 39(1):221–225

    PubMed  Google Scholar 

  • Doron SI, Dashe JF, Adelman LS, Brown WF, Werner BG, Hadley S (2003) Histopathologically proven poliomyelitis with quadriplegia and loss of brainstem function due to West Nile virus infection. Clin Infect Dis 37(5):e74–77

    Google Scholar 

  • Dridi M, Vangeluwe D, Lecollinet S, Berg T van den, Lambrecht B (2013) Experimental infection of Carrion crows (Corvus corone) with two European West Nile virus (WNV) strains. Vet Microbiol 165(1–2):160–166

    Google Scholar 

  • Dropulic B, Masters CL (1990) Entry of neurotropic arboviruses into the central nervous system: an in vitro study using mouse brain endothelium. J Infect Dis 161(4):685–691

    CAS  PubMed  Google Scholar 

  • Duprey Z, Rivers S, Luber G, Becker A, Blackmore C, Barr D, Weerasekera G, Kieszak S, Flanders WD, Rubin C (2008) Community aerial mosquito control and naled exposure. J Am Mosq Control Assoc 24(1):42–46

    PubMed  Google Scholar 

  • Durbin AP, Wright PF, Cox A, Kagucia W, Elwood D, Henderson S, Wanionek K, Speicher J, Whitehead SS, Pletnev AG (2013) The live attenuated chimeric vaccine rWN/DEN4Delta30 is well-tolerated and immunogenic in healthy flavivirus-naive adult volunteers. Vaccine 31:5772–5777

    CAS  PubMed  Google Scholar 

  • Ebel GD, Carricaburu J, Young D, Bernard KA, Kramer LD (2004) Genetic and phenotypic variation of West Nile virus in New York, 2000–2003. Am J Trop Med Hyg 71(4):493–500

    CAS  PubMed  Google Scholar 

  • El-Harrak M, Martin-Folgar R, Llorente F, Fernandez-Pacheco P, Brun A, Figuerola J, Jimenez-Clavero MA (2011) Rift Valley and West Nile virus antibodies in camels, North Africa. Emerg Infect Dis 17(12):2372–2374

    PubMed Central  PubMed  Google Scholar 

  • El Rhaffouli H, El Harrak M, Lotfi C, El Boukhrissi F, Bajjou T, Laraqui A, Hilali F, Kenfaoui M, Lahlou-Amine I (2012) Serologic evidence of West Nile virus infection among humans, Morocco. Emerg Infect Dis 18(5):880–881

    PubMed Central  PubMed  Google Scholar 

  • Emig M, Apple DJ (2004) Severe West Nile virus disease in healthy adults. Clin Infect Dis 38(2):289–292

    PubMed  Google Scholar 

  • Epp T, Waldner C, Leighton FA, Berke O, Townsend HG (2007) Seroprevalence and risk factors for infection with West Nile virus in Saskatchewan horses, 2003. Can J Vet Res 71(4):256–263

    PubMed Central  PubMed  Google Scholar 

  • Erdelyi K, Ursu K, Ferenczi E, Szeredi L, Ratz F, Skare J, Bakonyi T (2007) Clinical and pathologic features of lineage 2 West Nile virus infections in birds of prey in Hungary. Vector Borne Zoonotic Dis 7(2):181–188

    PubMed  Google Scholar 

  • Ezenwa VO, Godsey MS, King RJ, Guptill SC (2006) Avian diversity and West Nile virus: testing associations between biodiversity and infectious disease risk. Proc Biol Sci 273(1582):109–117

    PubMed Central  PubMed  Google Scholar 

  • Fan E, Needham DM, Brunton J, Kern RZ, Stewart TE (2004) West Nile virus infection in the intensive care unit: a case series and literature review. Can Respir J 11(5):354–358

    PubMed  Google Scholar 

  • Ferguson DD, Gershman K, LeBailly A, Petersen LR (2005) Characteristics of the rash associated with West Nile virus fever. Clin Infect Dis 41(8):1204–1207

    PubMed  Google Scholar 

  • Figuerola J, Baouab RE, Soriguer R, Fassi-Fihri O, Llorente F, Jimenez-Clavero MA (2009) West Nile virus antibodies in wild birds, Morocco, 2008. Emerg Infect Dis 15(10):1651–1653

    PubMed Central  PubMed  Google Scholar 

  • Fonseca K, Prince GD, Bratvold J, Fox JD, Pybus M, Preksaitis JK, Tilley P (2005) West Nile virus infection and conjunctival exposure. Emerg Infect Dis 11(10):1648–1649

    PubMed Central  PubMed  Google Scholar 

  • Foppa IM, Beard RH, Mendenhall IH (2011) The impact of West Nile virus on the abundance of selected North American birds. BMC Vet Res 7:43

    PubMed Central  PubMed  Google Scholar 

  • Fradin MS, Day JF (2002) Comparative efficacy of insect repellents against mosquito bites. N Engl J Med 347(1):13–18

    CAS  PubMed  Google Scholar 

  • Freifeld AG, Meza J, Schweitzer B, Shafer L, Kalil AC, Sambol AR (2010) Seroprevalence of West Nile virus infection in solid organ transplant recipients. Transpl Infect Dis 12(2):120–126

    CAS  PubMed  Google Scholar 

  • Gancz AY, Smith DA, Barker IK, Lindsay R, Hunter B (2006) Pathology and tissue distribution of West Nile virus in North American owls (family: Strigidae). Avian Pathol 35(1):17–29

    PubMed  Google Scholar 

  • Gardner IA, Wong SJ, Ferraro GL, Balasuriya UB, Hullinger PJ, Wilson WD, Shi PY, MacLachlan NJ (2007). Incidence and effects of West Nile virus infection in vaccinated and unvaccinated horses in California. Vet Res 38(1):109–116

    PubMed  Google Scholar 

  • George S, Gourie-Devi M, Rao JA, Prasad SR, Pavri KM (1984). Isolation of West Nile virus from the brains of children who had died of encephalitis. Bull World Health Organ 62(6):879–882

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gibbs SE, Allison AB, Yabsley MJ, Mead DG, Wilcox BR, Stallknecht DE (2006). West Nile virus antibodies in avian species of Georgia, USA: 2000–2004. Vector Borne Zoonotic Dis 6(1):57–72

    PubMed  Google Scholar 

  • Gibney KB, Lanciotti RS, Sejvar JJ, Nugent CT, Linnen JM, Delorey MJ, Lehman JA, Boswell EN, Staples JE, Fischer M (2011) West Nile virus RNA not detected in urine of 40 people tested 6 years after acute West Nile virus disease. J Infect Dis 203(3):344–347

    PubMed Central  PubMed  Google Scholar 

  • Gibney KB, Colborn J, Baty S, Bunko Patterson AM, Sylvester T, Briggs G, Stewart T, Levy C, Komatsu K, MacMillan K, Delorey MJ, Mutebi JP, Fischer M, Staples JE (2012) Modifiable risk factors for West Nile virus infection during an outbreak–Arizona, 2010. Am J Trop Med Hyg 86(5):895–901

    PubMed Central  PubMed  Google Scholar 

  • Glass JD, Samuels O, Rich MM (2002) Poliomyelitis due to West Nile virus. N Engl J Med 347(16):1280–1281

    PubMed  Google Scholar 

  • Glavits R, Ferenczi E, Ivanics E, Bakonyi T, Mato T, Zarka P, Palya V (2005) Co-occurrence of West Nile Fever and circovirus infection in a goose flock in Hungary. Avian Pathol 34(5):408–414

    PubMed  Google Scholar 

  • Godsey MS Jr, Burkhalter K, Young G, Delorey M, Smith K, Townsend J, Levy C, Mutebi JP (2012) Entomologic investigations during an outbreak of West Nile virus disease in Maricopa County, Arizona, 2010. Am J Trop Med Hyg 87(6):1125–1131

    PubMed Central  PubMed  Google Scholar 

  • Gorsche R, Tilley P (2005) The rash of West Nile virus infection. CMAJ 172(11):1440

    PubMed Central  PubMed  Google Scholar 

  • Green MS, Weinberger M, Ben-Ezer J, Bin H, Mendelson E, Gandacu D, Kaufman Z, Dichtiar R, Sobel A, Cohen D, Chowers MY (2005) Long-term death rates, West Nile virus epidemic, Israel, 2000. Emerg Infect Dis 11(11):1754–1757

    PubMed Central  PubMed  Google Scholar 

  • Guarner J, Shieh WJ, Hunter S, Paddock CD, Morken T, Campbell GL, Marfin AA, Zaki SR (2004) Clinicopathologic study and laboratory diagnosis of 23 cases with West Nile virus encephalomyelitis. Hum Pathol 35(8):983–990

    PubMed  Google Scholar 

  • Gubler DJ (2007) The continuing spread of West Nile virus in the Western Hemisphere. Clin Infect Dis 45(8):1039–1046

    PubMed  Google Scholar 

  • Gujral IB, Zielinski-Gutierrez EC, LeBailly A, Nasci R (2007) Behavioral risks for West Nile virus disease, northern Colorado, 2003. Emerg Infect Dis 13(3):419–425

    PubMed Central  PubMed  Google Scholar 

  • Haaland KY, Sadek J, Pergam S, Echevarria LA, Davis LE, Goade D, Harnar J, Nfchissey RA, Sewel CM, Ettestad P (2006) Mental status after West Nile virus infection. Emerg Infect Dis 12(8):1260–1262

    PubMed Central  PubMed  Google Scholar 

  • Harrigan RJ, Thomassen HA, Buermann W, Cummings RF, Kahn ME, Smith TB (2010) Economic conditions predict prevalence of West Nile virus. PLoS One 5(11):e15437

    PubMed Central  PubMed  Google Scholar 

  • Harris MC, Sleeman JM (2007) Morbidity and mortality of bald eagles (Haliaeetus leucocephalus) and peregrine falcons (Falco peregrinus) admitted to the Wildlife Center of Virginia, 1993–2003. J Zoo Wildl Med 38(1):62–66

    PubMed  Google Scholar 

  • Hartley DM, Barker CM, Le Menach A, Niu T, Gaff HD, Reisen WK (2012) Effects of temperature on emergence and seasonality of West Nile virus in California. Am J Trop Med Hyg 86(5):884–894

    PubMed Central  PubMed  Google Scholar 

  • Heinz F, Collet M, Purcell R, Gould E, Howeard C, Houghton M (2000) Family Flaviviridae. Virus Taxonomy: classification and nomenclature of viruses. M. Van Regenmortel. Academic, San Diego, pp 859–878

    Google Scholar 

  • Hinckley,AF, DR O’Leary, Hayes EB (2007) Transmission of West Nile virus through human breast milk seems to be rare. Pediatrics 119(3):e666–671

    PubMed  Google Scholar 

  • Hubalek Z, Halouzka J (1999) West Nile fever–a reemerging mosquito-borne viral disease in Europe. Emerg Infect Dis 5(5):643–650

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hunsperger EA, Roehrig JT (2006) Temporal analyses of the neuropathogenesis of a West Nile virus infection in mice. J Neurovirol 12(2):129–139

    PubMed  Google Scholar 

  • Hunsperger EA, McElroy KL, Bessoff K, Colon C, Barrera R, Munoz-Jordan JL (2009) West Nile virus from blood donors, vertebrates, and mosquitoes, Puerto Rico, 2007. Emerg Infect Dis 15(8):1298–1300

    PubMed Central  PubMed  Google Scholar 

  • Inojosa WO, Scotton PG, Fuser R, Giobbia M, Paolin A, Maresca MC, Brunello A, Nascimben E, Sorbara C, Rigoli R, Berti R, Gajo GB, Giometto B (2012) West Nile virus transmission through organ transplantation in north-eastern Italy: a case report and implications for pre-procurement screening. Infection 40(5):557–562

    CAS  PubMed  Google Scholar 

  • Iwamoto M, Jernigan DB, Guasch A, Trepka MJ, Blackmore CG, Hellinger WC, Pham SM, Zaki S, Lanciotti RS, Lance-Parker SE, DiazGranados CA, Winquist AG, Perlino CA, Wiersma S, Hillyer KL, Goodman JL, Marfin AA, Chamberland ME, Petersen LR (2003) Transmission of West Nile virus from an organ donor to four transplant recipients. N Engl J Med 348(22):2196–2203

    PubMed  Google Scholar 

  • Jeha LE, Sila CA, Lederman RJ, Prayson RA, Isada CM, Gordon SM (2003) West Nile virus infection: a new acute paralytic illness. Neurology 61(1):55–59

    CAS  PubMed  Google Scholar 

  • Johnson AJ, Noga AJ, Kosoy O, Lanciotti RS, Johnson AA, Biggerstaff BJ (2005a) Duplex microsphere-based immunoassay for detection of anti-West Nile virus and anti-St. Louis encephalitis virus immunoglobulin m antibodies. Clin Diagn Lab Immunol 12(5):566–574

    Google Scholar 

  • Johnson BW, Kosoy O, Martin DA, Noga AJ, Russell BJ, Johnson AA, Petersen LR (2005b) West Nile virus infection and serologic response among persons previously vaccinated against yellow fever and Japanese encephalitis viruses. Vector Borne Zoonotic Dis 5(2):137–145

    Google Scholar 

  • Jupp PG (2001) The ecology of West Nile virus in South Africa and the occurrence of outbreaks in humans. Ann N Y Acad Sci 951:143–152

    CAS  PubMed  Google Scholar 

  • Kading RC, Borland EM, Cranfield M, Powers AM (2013) Prevalence of antibodies to alphaviruses and flaviviruses in free-ranging game animals and nonhuman primates in the Greater Congo Basin. J Wildl Dis 40(3):587–599

    Google Scholar 

  • Kalaycioglu H, Korukluoglu G, Ozkul A, Oncul O, Tosun S, Karabay O, Gozalan A, Uyar Y, Caglayik DY, Atasoylu G, Altas AB, Yolbakan S, Ozden TN, Bayrakdar F, Sezak N, Pelitli TS, Kurtcebe ZO, Aydin E, Ertek M (2012) Emergence of West Nile virus infections in humans in Turkey, 2010 to 2011. Euro Surveill 17(21):pii=20182

    Google Scholar 

  • Kanagarajan K, Ganesh S, Alakhras M, Go ES, Recco RA, Zaman MM (2003) West Nile virus infection presenting as cerebellar ataxia and fever: case report. South Med J 96(6):600–601

    PubMed  Google Scholar 

  • Kelley TW, Prayson RA, Ruiz AI, Isada CM, Gordon SM (2003) The neuropathology of West Nile virus meningoencephalitis. A report of two cases and review of the literature. Am J Clin Pathol 119(5):749–753

    PubMed  Google Scholar 

  • Khan SA, Dutta P, Khan AM, Chowdhury P, Borah J, Doloi P, Mahanta J (2011) West Nile virus infection, Assam, India. Emerg Infect Dis 17(5):947–948

    PubMed Central  PubMed  Google Scholar 

  • Kilpatrick AM, Daszak P, Jones MJ, Marra PP, Kramer LD (2006a) Host heterogeneity dominates West Nile virus transmission. Proc Biol Sci 273(1599):2327–2333

    Google Scholar 

  • Kilpatrick AM, Kramer LD, Jones MJ, Marra PP, Daszak P (2006b) West Nile virus epidemics in North America are driven by shifts in mosquito feeding behavior. PLoS Biol 4(4):e82

    Google Scholar 

  • Kilpatrick AM, Meola MA, Moudy RM, Kramer LD (2008) Temperature, viral genetics, and the transmission of West Nile virus by Culex pipiens mosquitoes. PLoS Pathog 4(6):e1000092

    PubMed Central  PubMed  Google Scholar 

  • Klee, AL, Maidin B, Edwin B, Poshni I, Mostashari F, Fine A, Layton M, Nash D (2004) Long-term prognosis for clinical West Nile virus infection. Emerg Infect Dis 10(8):1405–1411

    PubMed Central  PubMed  Google Scholar 

  • Klenk K, Snow J, Morgan K, Bowen R, Stephens M, Foster F, Gordy P, Beckett S, Komar N, Gubler D, Bunning M (2004) Alligators as West Nile virus amplifiers. Emerg Infect Dis 10(12):2150–2155

    PubMed Central  PubMed  Google Scholar 

  • Knope K, Whelan P, Smith D, Johansen C, Moran R, Doggett S, Sly A, Hobby M, Kurucz N, Wright P, Nicholson J, A. National and C. Malaria Advisory (2013) Arboviral diseases and malaria in Australia, 2010–2011: annual report of the National Arbovirus and Malaria Advisory Committee. Commun Dis Intell Q Rep 37(1):E1–20

    PubMed  Google Scholar 

  • Komar N, Clark GG (2006) West Nile virus activity in Latin America and the Caribbean. Rev Panam Salud Publica 19(2):112–117

    PubMed  Google Scholar 

  • Komar N, Burns J, Dean C, Panella NA, Dusza S, Cherry B (2001a) Serologic evidence for West Nile virus infection in birds in Staten Island, New York, after an outbreak in 2000. Vector Borne Zoonotic Dis 1(3):191–196

    Google Scholar 

  • Komar N, Panella NA, Burns JE, Dusza SW, Mascarenhas TM, Talbot TO (2001b) Serologic evidence for West Nile virus infection in birds in the New York City vicinity during an outbreak in 1999. Emerg Infect Dis 7(4):621–625

    Google Scholar 

  • Komar N, Langevin S, Hinten S, Nemeth N, Edwards E, Hettler D, Davis B, Bowen R, Bunning M (2003) Experimental infection of North American birds with the New York 1999 strain of West Nile virus. Emerg Infect Dis 9(3):311–322

    PubMed Central  PubMed  Google Scholar 

  • Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR (2008) Dysregulation of TLR3 Impairs the innate immune response to West Nile virus in the elderly. J Virol 82(15):7613–7623

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kumar D, Drebot MA, Wong SJ, Lim G, Artsob H, Buck P, Humar A (2004) A seroprevalence study of West Nile virus infection in solid organ transplant recipients. Am J Transpl 4(11):1883–1888

    Google Scholar 

  • Kuniholm MH, Wolfe ND, Huang CY, Mpoudi-Ngole E, Tamoufe U, LeBreton M, Burke DS, Gubler DJ (2006) Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults. Am J Trop Med Hyg 74(6):1078–1083

    PubMed  Google Scholar 

  • LaBeaud AD, Kile JR, Kippes C, King CH, Mandalakas AM (2007) Exposure to West Nile virus during the 2002 epidemic in Cuyahoga County, Ohio: a comparison of pediatric and adult behaviors. Public Health Rep 122(3):356–361

    PubMed Central  PubMed  Google Scholar 

  • LaDeau SL, Kilpatrick AM, Marra PP (2007) West Nile virus emergence and large-scale declines of North American bird populations. Nature 447(7145):710–713

    CAS  PubMed  Google Scholar 

  • Lanciotti RS, Roehrig JT, Deubel V, Smith J, Parker M, Steele K, Crise B, Volpe KE, Crabtree MB, Scherret JH, Hall RA, MacKenzie JS, Cropp CB, Panigrahy B, Ostlund E, Schmitt B, Malkinson M, Banet C, Weissman J, Komar N, Savage HM, Stone W, McNamara T, Gubler DJ (1999) Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science 286(5448):2333–2337

    CAS  PubMed  Google Scholar 

  • Lanciotti RS, Ebel GD, Deubel V, Kerst AJ, Murri S, Meyer R, Bowen M, Mc NKinney, Morrill WE, Crabtree MB, Kramer LD, Roehrig JT (2002) Complete genome sequences and phylogenetic analysis of West Nile virus strains isolated from the United States, Europe, and the Middle East. Virology 298(1):96–105

    CAS  PubMed  Google Scholar 

  • Landesman WJ, Allan BF, Langerhans RB, Knight TM, Chase JM (2007) Inter-annual associations between precipitation and human incidence of West Nile virus in the United States. Vector Borne Zoonotic Dis 7(3):337–343

    PubMed  Google Scholar 

  • Le Guenno B, Bougermouh A, Azzam T, Bouakaz R (1996) West Nile: a deadly virus? Lancet 348(9037):1315

    CAS  PubMed  Google Scholar 

  • Leis AA, Stokic DS (2012) Neuromuscular manifestations of West Nile virus infection. Front Neurol 3(Article 37):1–10

    Google Scholar 

  • Leis AA, Stokic DS, Polk JL, Dostrow V, Winkelmann M (2002) A poliomyelitis-like syndrome from West Nile virus infection. N Engl J Med 347(16):1279–1280

    PubMed  Google Scholar 

  • Leis AA, Stokic DS, Webb RM, Slavinski SA, Fratkin J (2003) Clinical spectrum of muscle weakness in human West Nile virus infection. Muscle Nerve 28(3):302–308

    PubMed  Google Scholar 

  • Lelli R, Calistri P, Bruno R, Monaco F, Savini G, Di Sabatino D, Corsi I, Pascucci I (2012) West Nile transmission in resident birds in Italy. Transbound Emerg Dis 59(5):421–428

    CAS  PubMed  Google Scholar 

  • Li J, Loeb JA, Shy ME, Shah AK, Tselis AC, Kupski WJ, Lewis RA (2003) Asymmetric flaccid paralysis: a neuromuscular presentation of West Nile virus infection. Ann Neurol 53(6):703–710

    PubMed  Google Scholar 

  • Li XL, Fu SH, Liu WB, Wang HY, Lu Z, Tong SX, Li ZX, Nasci RS, Kosoy O, Cui Y, Liang GD (2013) West Nile virus infection in Xinjiang, China. Vector Borne Zoonotic Dis 13(2):131–133

    PubMed  Google Scholar 

  • Lim PY, Behr MJ, Chadwick CM, Shi PY, Bernard KA (2011) Keratinocytes are cell targets of West Nile Virus in vivo. J Virol 85(10):5197–5201

    Google Scholar 

  • Lindsey NP, Kuhn S, Campbell GL, Hayes EB (2008) West Nile virus neuroinvasive disease incidence in the United States, 2002–2006. Vector Borne Zoonotic Dis 8(1):35–39

    PubMed  Google Scholar 

  • Lindsey NP, Staples JE, Lehman JA, Fischer M, C. Centers for Disease and Prevention (2010) Surveillance for human West Nile virus disease—United States, 1999–2008. MMWR Morb Mortal Wkly Rep Surveill Summ 59(2):1–17

    Google Scholar 

  • Lindsey NP, Sejvar JJ, Bode AV, Pape WJ, Campbell GL (2012a) Delayed mortality in a cohort of persons hospitalized with West Nile virus disease in Colorado in 2003. Vector Borne Zoonotic Dis 12(3):230–235

    Google Scholar 

  • Lindsey NP, Staples JE, Lehman JA, Fischer M (2012b) Medical risk factors for severe West Nile virus disease, United States, 2008–2010. Am J Trop Med Hyg 87(1):179–184

    Google Scholar 

  • Linke S, Niedrig M, Kaiser A, Ellerbrok H, Muller K, Muller T, Conraths FJ, Muhle RU, Schmidt D, Koppen U, Bairlein F, Berthold P, Pauli G (2007) Serologic evidence of West Nile virus infections in wild birds captured in Germany. Am J Trop Med Hyg 77(2):358–364

    PubMed  Google Scholar 

  • Loeb M, Elliott SJ, Gibson B, Fearon M, Nosal R, Drebot M, D’Cuhna C, Harrington D, Smith S, George P, Eyles J (2005) Protective behavior and West Nile virus risk. Emerg Infect Dis 11(9):1433–1436

    PubMed Central  PubMed  Google Scholar 

  • Loeb M, Hanna S, Nicolle L, Eyles J, Elliott S, Rathbone M, Drebot M, Neupane B, Fearon M, Mahony J (2008) Prognosis after West Nile virus infection. Ann Intern Med 149(4):232–241

    PubMed  Google Scholar 

  • Long MT, Gibbs EP, Mellencamp MW, Bowen RA, Seino KK, Zhang S, Beachboard SE, Humphrey PP (2007a) Efficacy, duration, and onset of immunogenicity of a West Nile virus vaccine, live Flavivirus chimera, in horses with a clinical disease challenge model. Equine Vet J 39(6):491–497

    Google Scholar 

  • Long MT, Gibbs EP, Mellencamp MW, Zhang S, Barnett DC, Seino KK, Beachboard SE, Humphrey PP (2007b) Safety of an attenuated West Nile virus vaccine, live Flavivirus chimera in horses. Equine Vet J 39(6):486–490

    Google Scholar 

  • Lothrop HD, Lothrop BB, Gomsi DE, Reisen WK (2008) Intensive early season adulticide applications decrease arbovirus transmission throughout the Coachella Valley, Riverside County, California. Vector Borne Zoonotic Dis 8(4):475–489

    PubMed Central  PubMed  Google Scholar 

  • Macedo PA, Schleier JJ 3rd, Reed M, Kelley K, Goodman GW, Brown DA, Peterson RK (2010) Evaluation of efficacy and human health risk of aerial ultra-low volume applications of pyrethrins and piperonyl butoxide for adult mosquito management in response to West Nile virus activity in Sacramento County, California. J Am Mosq Control Assoc 26(1):57–66

    CAS  PubMed  Google Scholar 

  • Magurano F, Remoli ME, Baggieri M, Fortuna C, Marchi A, Fiorentini C, Bucci P, Benedetti E, Ciufolini MG, Rizzo C, Piga S, Salcuni P, Rezza G, Nicoletti L (2012) Circulation of West Nile virus lineage 1 and 2 during an outbreak in Italy. Clin Microbiol Infect 18(12):E545–547

    Google Scholar 

  • Malkinson M, Banet C (2002) The role of birds in the ecology of West Nile virus in Europe and Africa. Curr Top Microbiol Immunol 267:309–322

    CAS  PubMed  Google Scholar 

  • Malkinson M, Banet C, Weisman Y, Pokamunski S, King R, Drouet MT, Deubel V (2002) Introduction of West Nile virus in the Middle East by migrating white storks. Emerg Infect Dis 8(4):392–397

    PubMed Central  PubMed  Google Scholar 

  • Martin JE, Pierson TC, Habka S, Rucker S, Gordon IJ, ME, Enama, Andrews CA Xu Q, Davis BS, Nason M, Fay M, Koup RA, Roederer M, Bailer RT, Gomez PL, Mascola JR, Chang GJ, Nabel GJ, Graham BS (2007) A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults in a phase one clinical trial. J Infect Dis 196:1732–1740

    PubMed Central  PubMed  Google Scholar 

  • Martina BE, Koraka P, Osterhaus AD (2010) West Nile virus: is a vaccine needed? Curr Opin Investig Drugs 11(2):139–146

    CAS  PubMed  Google Scholar 

  • Mattar S, Edwards E, Laguado J, Gonzalez M, Alvarez J, Komar N (2005) West Nile virus antibodies in Colombian horses. Emerg Infect Dis 11(9):1497–1498

    PubMed Central  PubMed  Google Scholar 

  • May FJ, Davis CT, Tesh RB, Barrett AD (2011) Phylogeography of West Nile virus: from the cradle of evolution in Africa to Eurasia, Australia, and the Americas. J Virol 85(6):2964–2974

    CAS  PubMed Central  PubMed  Google Scholar 

  • McCarthy TA, Hadler JL, Julian K, Walsh SJ, Biggerstaff BJ, Hinten SR, Baisley C, Iton A, Brennan T, Nelson RS, Achambault G, Marfin AA, Petersen LR (2001) West Nile virus serosurvey and assessment of personal prevention efforts in an area with intense epizootic activity: Connecticut, 2000. Ann N Y Acad Sci 951:307–316

    CAS  PubMed  Google Scholar 

  • McIntosh BM, McGillivray GM, Dickinson DB, Taljaard JJ (1968) Ecological studies on Sindbis and West Nile viruses in South Africa. IV. Infection in a wild avian population. S Afr J Med Sci 33(4):105–112

    CAS  PubMed  Google Scholar 

  • McKenzie VJ, Goulet NE (2010) Bird community composition linked to human West Nile virus cases along the Colorado front range. Ecohealth 7(4):439–447

    PubMed  Google Scholar 

  • McMullen AR, Albayrak H, May FJ, Davis CT, Beasley DW, Barrett AD (2013) Molecular evolution of lineage 2 West Nile virus. J Gen Virol 94(Pt 2):318–325

    CAS  PubMed Central  PubMed  Google Scholar 

  • Meyer TE, Bull LM, Cain Holmes K, Pascua RF, Travassos da Rosa A, Gutierrez CR, Corbin T, Woodward JL, Taylor JP, Tesh RB, Murray KO (2007) West Nile virus infection among the homeless, Houston, Texas. Emerg Infect Dis 13(10):1500–1503

    PubMed Central  PubMed  Google Scholar 

  • Miramontes R Jr, Lafferty WE, Lind BK, Oberle MW (2006) Is agricultural activity linked to the incidence of human West Nile virus? Am J Prev Med 30(2):160–163

    PubMed  Google Scholar 

  • Morrill JC, Johnson BK, Hyams C, Okoth F, Tukei PM, Mugambi M, Woody J (1991) Serological evidence of arboviral infections among humans of coastal Kenya. J Trop Med Hyg 94(3):166–168

    CAS  PubMed  Google Scholar 

  • Mostashari F, Bunning ML, Kitsutani PT, Singer DA, Nash D, Cooper MJ, Katz N, Liljebjelke KA, Biggerstaff BJ, Fine AD, Layton MC, Mullin SM, Johnson AJ, Martin DA, Hayes EB, Campbell GL (2001) Epidemic West Nile encephalitis, New York, 1999: results of a household-based seroepidemiological survey. Lancet 358(9278):261–264

    CAS  PubMed  Google Scholar 

  • Murata R, Hashiguchi K, Yoshii K, Kariwa H, Nakajima K, Ivanov LI, Leonova GN, Takashima I (2011) Seroprevalence of West Nile virus in wild birds in far eastern Russia using a focus reduction neutralization test. Am J Trop Med Hyg 84(3):461–465

    PubMed Central  PubMed  Google Scholar 

  • Murgue B, Murri S, Triki H, Deubel V, Zeller HG (2001a) West Nile in the Mediterranean basin:1950–2000. Ann N Y Acad Sci 951:117–126

    Google Scholar 

  • Murgue B, Murri S, Zientara S, Durand B, Durand JP, Zeller H (2001b) West Nile outbreak in horses in southern France, 2000: the return after 35 years. Emerg Infect Dis 7(4):692–696

    Google Scholar 

  • Murgue B, Zeller H, Deubel V (2002) The ecology and epidemiology of West Nile virus in Africa, Europe and Asia. Curr Top Microbiol Immunol 267:195–221

    CAS  PubMed  Google Scholar 

  • Murray K, Baraniuk S, Resnick M, Arafat R, Kilborn C, Cain K, Shallenberger R, York TL, Martinez D, Hellums JS, Hellums D, Malkoff M, Elgawley N, McNeely W, Khuwaja SA, Tesh RB (2006) Risk factors for encephalitis and death from West Nile virus infection. Epidemiol Infect 134(6):1325–1332

    CAS  PubMed Central  PubMed  Google Scholar 

  • Murray K, Walker C, Herrington E, Lewis JA, McCormick J, Beasley DW, Tesh RB, Fisher-Hoch S (2010) Persistent infection with West Nile virus years after initial infection. J Infect Dis 201(1):2–4

    CAS  PubMed Central  PubMed  Google Scholar 

  • Murray KO, Resnick M, Miller V (2007) Depression after infection with West Nile virus. Emerg Infect Dis 13(3):479–481

    PubMed Central  PubMed  Google Scholar 

  • Naficy K, Saidi S (1970) Serological survey on viral antibodies in Iran. Trop Geogr Med 22(2):183–188

    CAS  PubMed  Google Scholar 

  • Naowarat S, Tang IM (2004) Effect of bird-to-bird transmission of the West Nile virus on the dynamics of the transmission of this disease. Southeast Asian J Trop Med Public Health 35(1):162–166

    PubMed  Google Scholar 

  • Nasci RS, Savage HM, White DJ, Miller JR, Cropp BC, Godsey MS, Kerst AJ, Bennett P, Gottfried K, Lanciotti RS (2001) West Nile virus in overwintering Culex mosquitoes, New York City, 2000. Emerg Infect Dis 7(4):742–744

    CAS  PubMed Central  PubMed  Google Scholar 

  • Nash D, Mostashari F, Fine A, Miller J, O’Leary D, Murray K, Huang A, Rosenberg A, Greenberg A, Sherman M, Wong S, Layton M (2001) The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med 344(24):1807–1814

    CAS  PubMed  Google Scholar 

  • Nemeth N, Gould D, Bowen R, Komar N (2006) Natural and experimental West Nile virus infection in five raptor species. J Wildl Dis 42(1):1–13

    PubMed  Google Scholar 

  • Nemeth NM, Beckett S, Edwards E, Klenk K, Komar N (2007) Avian mortality surveillance for West Nile virus in Colorado. Am J Trop Med Hyg 76(3):431–437

    PubMed  Google Scholar 

  • Nett RJ, Kuehnert MJ, Ison MG, Orlowski JP, Fischer M, Staples JE (2012) Current practices and evaluation of screening solid organ donors for West Nile virus. Transpl Infect Dis 14(3):268–277

    CAS  PubMed  Google Scholar 

  • Nir Y, Beemer A, Goldwasser RA (1965) West Nile virus infection in mice following exposure to a viral aerosol. Br J Exper Pathol 46(4):443–449

    CAS  Google Scholar 

  • Nur YA, Groen J, Heuvelmans H, Tuynman W, Copra C, Osterhaus AD (1999) An outbreak of West Nile fever among migrants in Kisangani, Democratic Republic of Congo. Am J Trop Med Hyg 61(6):885–888

    CAS  PubMed  Google Scholar 

  • O’Leary DR, Kuhn S, Kniss KL, Hinckley AF, Rasmussen SA, Pape WJ, Kightlinger LK, Beecham BD, Miller TK, Neitzel DF, Michaels SR, Campbell GL, Lanciotti RS, Hayes EB (2006) Birth outcomes following West Nile Virus infection of pregnant women in the United States: 2003–2004. Pediatrics 117(3):e537–545

    PubMed  Google Scholar 

  • Ochieng C, Lutomiah J, Makio A, Koka H, Chepkorir E, Yalwala S, Mutisya J, Musila L, Khamadi S, Richardson J, Bast J, Schnabel D, Wurapa E, Sang R (2013) Mosquito-borne arbovirus surveillance at selected sites in diverse ecological zones of Kenya; 2007–2012. Virol J 10(1):140

    PubMed Central  PubMed  Google Scholar 

  • Orton SL, Stramer SL, Dodd RY (2006) Self-reported symptoms associated with West Nile virus infection in RNA-positive blood donors. Transfusion 46(2):272–277

    CAS  PubMed  Google Scholar 

  • Paisley JE, Hinckley AF, O’Leary DR, Kramer WC, Lanciotti RS, Campbell GL, Hayes EB (2006) West Nile virus infection among pregnant women in a northern Colorado community, 2003 to 2004. Pediatrics 117(3):814–820

    PubMed  Google Scholar 

  • Papa A (2012) West Nile virus infections in Greece: an update. Expert Rev Anti Infect Ther 10(7):743–750

    CAS  PubMed  Google Scholar 

  • Papa A, Bakonyi T, Xanthopoulou K, Vazquez A, Tenorio A, Nowotny N (2011a) Genetic characterization of West Nile virus lineage 2, Greece, 2010. Emerg Infect Dis 17(5):920–922

    Google Scholar 

  • Papa A, Danis K, Athanasiadou A, Delianidou M, Panagiotopoulos T (2011b) Persistence of West Nile virus immunoglobulin M antibodies, Greece. J Med Virol 83(10):1857–1860

    Google Scholar 

  • Papa A, Danis K, Tsergouli K, Tsioka K, Gavana E (2011c) Development time of IgG antibodies to West Nile virus. Arch Virol 156(9):1661–1663

    Google Scholar 

  • Papa A, Papadopoulou E, Gavana E, Kalaitzopoulou S, Mourelatos S (2013) Detection of west nile virus lineage 2 in Culex mosquitoes, Greece, 2012. Vector Borne Zoonotic Dis 13(9):682–684

    PubMed  Google Scholar 

  • Parreira R, Severino P, Freitas F, Piedade J, Almeida AP, Esteves A (2007) Two distinct introductions of the West Nile virus in Portugal disclosed by phylogenetic analysis of genomic sequences. Vector Borne Zoonotic Dis 7(3):344–352

    CAS  PubMed  Google Scholar 

  • Paul SD, Murthy DP, Das M (1970) Isolation of West Nile virus from a human case of febrile illness. Indian J Med Res 58(9):1177–1179

    CAS  PubMed  Google Scholar 

  • Pealer LN, Marfin AA, Petersen LR, Lanciotti RS, Page PL, Stramer SL, Stobierski MG, Signs K, Newman B, Kapoor H, Goodman JL, Chamberland ME (2003) Transmission of West Nile virus through blood transfusion in the United States in 2002. N Engl J Med 349(13):1236–1245

    CAS  PubMed  Google Scholar 

  • Pepperell C, Rau N, Krajden S, Kern R, Humar A, Mederski B, Simor A, Low DE, McGeer A, Mazzulli T, Burton J, Jaigobin C, Fearon M, Artsob H, Drebot MA, Halliday W, Brunton J (2003) West Nile virus infection in 2002: morbidity and mortality among patients admitted to hospital in southcentral Ontario. CMAJ 168(11):1399–1405

    PubMed Central  PubMed  Google Scholar 

  • Petersen LR, Epstein JS (2005) Problem solved? West Nile virus and transfusion safety. N Engl J Med 353(5):516–517

    CAS  PubMed  Google Scholar 

  • Petersen LR, Fischer M (2012) Unpredictable and difficult to control–the adolescence of West Nile virus. N Engl J Med 367(14):1281–1284

    CAS  PubMed  Google Scholar 

  • Petersen LR, Hayes EB (2008) West Nile virus in the Americas. Med Clin North Am 92(6):1307–1322, ix

    PubMed  Google Scholar 

  • Petersen LR, Roehrig JT (2007) Flavivirus DNA vaccines–good science, uncertain future. J Infect Dis 196(12):1721–1723

    PubMed  Google Scholar 

  • Petersen LR, Carson PJ, Biggerstaff BJ, Custer B, Borchardt SM, Busch MP (2012) Estimated cumulative incidence of West Nile virus infection in US adults, 1999–2010. Epidemiol Infect 1–5

    Google Scholar 

  • Petersen LR, Brault AC, Nasci RS (2013) West Nile virus: review of the literature. JAMA 310(3):308–315

    CAS  PubMed  Google Scholar 

  • Platonov AE (2001) West Nile encephalitis in Russia 1999–2001: were we ready? Are we ready? Ann N Y Acad Sci 951:102–116

    CAS  PubMed  Google Scholar 

  • Platonov AE, Shipulin GA, Shipulina OY, Tyutyunnik EN, Frolochkina TI, Lanciotti RS, Yazyshina S, Platonova OV, Obukhov IL, Zhukov AN, Vengerov YY, Pokrovskii VI (2001) Outbreak of West Nile virus infection, Volgograd Region, Russia, 1999. Emerg Infect Dis 7(1):128–132

    CAS  PubMed Central  PubMed  Google Scholar 

  • Platt KB, Tucker BJ, Halbur PG, Tiawsirisup S, Blitvich BJ, Fabiosa FG, Bartholomay LC, Rowley WA (2007) West Nile virus viremia in eastern chipmunks (Tamias striatus) sufficient for infecting different mosquitoes. Emerg Infect Dis 13(6):831–837

    PubMed Central  PubMed  Google Scholar 

  • Platt KB, Tucker BJ, Halbur PG, Blitvich BJ, Fabiosa FG, Mullin K, Parikh GR, Kitikoon P, Bartholomay LC, Rowley WA (2008) Fox squirrels (Sciurus niger) develop West Nile virus viremias sufficient for infecting select mosquito species. Vector Borne Zoonotic Dis 8(2):225–233

    PubMed  Google Scholar 

  • Pogodina VV, Frolova MP, Malenko GV, Fokina GI, Koreshkova GV, Kiseleva LL, Bochkova NG, Ralph NM (1983) Study on West Nile virus persistence in monkeys. Arch Virol 75(1–2):71–86

    CAS  PubMed  Google Scholar 

  • Porter MB, Long MT, Getman LM, Giguere S, MacKay RJ, Lester GD, Alleman AR, Wamsley HL, Franklin RP, Jacks S, Buergelt CD, Detrisac CJ (2003) West Nile virus encephalomyelitis in horses: 46 cases (2001). J Am Vet Med Assoc 222(9):1241–1247

    PubMed  Google Scholar 

  • Pupo M, Guzman MG, Fernandez R, Llop A, Dickinson FO, Perez D, Cruz R, Gonzalez T, Estevez G, Gonzalez H, Santos P, Kouri G, Andonova M, Lindsay R, Artsob H, Drebot M (2006) West Nile Virus infection in humans and horses, Cuba. Emerg Infect Dis 12(6):1022–1024

    PubMed Central  PubMed  Google Scholar 

  • Reed LM, Johansson MA, Panella N, McLean R, Creekmore T, Puelle R, Komar N (2009) Declining mortality in American crow (Corvus brachyrhynchos) following natural West Nile virus infection. Avian Dis 53(3):458–461

    PubMed  Google Scholar 

  • Reisen WK (2012) The contrasting bionomics of Culex mosquitoes in western North America. J Am Mosq Control Assoc 28(4 Suppl):82–91

    PubMed  Google Scholar 

  • Reisen WK, Brault AC (2007) West Nile virus in North America: perspectives on epidemiology and intervention. Pest Manag Sci 63(7):641–646

    CAS  PubMed  Google Scholar 

  • Reisen WK, Meyer RP, Tempelis CH, Spoehel JJ (1990) Mosquito abundance and bionomics in residential communities in Orange and Los Angeles Counties, California. J Med Entomol 27(3):356–367

    CAS  PubMed  Google Scholar 

  • Reisen WK, Fang Y, Lothrop HD, Martinez VM, Wilson J, Oconnor P, Carney R, Cahoon-Young B, Shafii M, Brault AC (2006a) Overwintering of West Nile virus in Southern California. J Med Entomol 43(2):344–355

    Google Scholar 

  • Reisen WK, Fang Y, Martinez VM (2006b) Effects of temperature on the transmission of West Nile virus by Culex tarsalis (Diptera: Culicidae). J Med Entomol 43(2):309–317

    Google Scholar 

  • Reisen WK, Takahashi RM, Carroll BD, Quiring R (2008) Delinquent mortgages, neglected swimming pools, and West Nile virus, California. Emerg Infect Dis 14(11):1747–1749

    PubMed Central  PubMed  Google Scholar 

  • Reiter P (2010) West Nile virus in Europe: understanding the present to gauge the future. Euro Surveill 15(10):19508

    Google Scholar 

  • Rhee C, Eaton EF, Concepcion W, Blackburn BG (2011) West Nile virus encephalitis acquired via liver transplantation and clinical response to intravenous immunoglobulin: case report and review of the literature. Transpl Infect Dis 13(3):312–317

    CAS  PubMed  Google Scholar 

  • Riabi S, Gallian P, Gaaloul I, Simon S, Harrath R, Hassine M, de Micco P, Aouni M (2010) Prevalence of IgG antibodies against West Nile virus in blood donors during the 2003 outbreak in Tunisia. Trans R Soc Trop Med Hyg 104(7):507–509

    PubMed  Google Scholar 

  • Richards SL, Mores CN, Lord CC, Tabachnick WJ (2007) Impact of extrinsic incubation temperature and virus exposure on vector competence of Culex pipiens quinquefasciatus Say (Diptera: Culicidae) for West Nile virus. Vector Borne Zoonotic Dis 7(4):629–636

    PubMed Central  PubMed  Google Scholar 

  • Ringia AM, Blitvich BJ, Koo HY, Van de Wyngaerde M, Brawn JD, Novak RJ (2004) Antibody prevalence of West Nile virus in birds, Illinois, 2002. Emerg Infect Dis 10(6):1120–1124

    PubMed Central  PubMed  Google Scholar 

  • Rizzo C, Salcuni P, Nicoletti L, Ciufolini MG, Russo F, Masala R, Frongia O, Finarelli AC, Gramegna M, Gallo L, Pompa MG, Rezza G, Salmaso S, Declich S (2012) Epidemiological surveillance of West Nile neuroinvasive diseases in Italy, 2008 to 2011. Euro Surveill 17(20):pii: 20172

    Google Scholar 

  • Robinson RL, Shahida S, Madan N, Rao S, Khardori N (2003) Transient parkinsonism in West Nile virus encephalitis. Am J Med 115(3):252–253

    PubMed  Google Scholar 

  • Roehrig JT, Nash D, Maldin B, Labowitz A, Martin DA, Lanciotti RS, Campbell GL (2003) Persistence of virus-reactive serum immunoglobulin m antibody in confirmed west nile virus encephalitis cases. Emerg Infect Dis 9(3):376–379

    CAS  PubMed Central  PubMed  Google Scholar 

  • Root JJ, Oesterle PT, Nemeth NM, Klenk K, Gould DH, McLean RG, Clark L, Hall JS (2006) Experimental infection of fox squirrels (Sciurus niger) with West Nile virus. Am J Trop Med Hyg 75(4):697–701

    PubMed  Google Scholar 

  • Ruiz MO, Walker ED, Foster ES, Haramis LD, Kitron UD (2007) Association of West Nile virus illness and urban landscapes in Chicago and Detroit. Int J Health Geogr 6:10

    PubMed Central  PubMed  Google Scholar 

  • Sadek JR, Pergam SA, Harrington JA, Echevarria LA, Davis LE, Goade D, Harnar J, Nofchissey RA, Sewell CM, Ettestad P, Haaland KY (2010) Persistent neuropsychological impairment associated with West Nile virus infection. J Clin Exp Neuropsychol 32(1):81–87

    PubMed  Google Scholar 

  • Saito EK, Sileo L, Green DE, Meteyer CU, McLaughlin GS, Converse KA, Docherty DE (2007) Raptor mortality due to West Nile virus in the United States, 2002. J Wildl Dis 43(2):206–213

    PubMed  Google Scholar 

  • Salazar P, Traub-Dargatz JL, Morley PS, Wilmot DD, Steffen DJ, Cunningham WE, Salman MD (2004) Outcome of equids with clinical signs of West Nile virus infection and factors associated with death. J Am Vet Med Assoc 225(2):267–274

    PubMed  Google Scholar 

  • Savage HM, Ceianu C, Nicolescu G, Karabatsos N, Lanciotti R, Vladimirescu A, Laiv L, Ungureanu A, Romanca C, Tsai TF (1999) Entomologic and avian investigations of an epidemic of West Nile fever in Romania in 1996, with serologic and molecular characterization of a virus isolate from mosquitoes. Am J Trop Med Hyg 61(4):600–611

    CAS  PubMed  Google Scholar 

  • Savage HM, Aggarwal D, Apperson CS, Katholi CR, Gordon E, Hassan HK, Anderson M, Charnetzky D, McMillen L, Unnasch EA, Unnasch TR (2007) Host choice and West Nile virus infection rates in blood-fed mosquitoes, including members of the Culex pipiens complex, from Memphis and Shelby County, Tennessee, 2002–2003. Vector Borne Zoonotic Dis 7(3):365–386

    PubMed Central  PubMed  Google Scholar 

  • Savini G, Capelli G, Monaco F, Polci A, Russo F, Di Gennaro A, Marini V, Teodori L, Montarsi F, Pinoni C, Pisciella M, Terregino C, Marangon S, Capua I, Lelli R (2012) Evidence of West Nile virus lineage 2 circulation in Northern Italy. Vet Microbiol 158(3–4):267–273

    CAS  PubMed  Google Scholar 

  • Sayao AL, Suchowersky O, Al-Khathaami A, Klassen B, Katz NR, Sevick R, Tilley P, Fox J, Patry D (2004) Calgary experience with West Nile virus neurological syndrome during the late summer of 2003. Can J Neurol Sci 31(2):194–203

    PubMed  Google Scholar 

  • Schellenberg TL, Anderson ME, Drebot MA, Vooght MT, Findlater AR, Curry PS, Campbell CA, Osei WD (2006) Seroprevalence of West Nile virus in Saskatchewan’s Five Hills Health Region, 2003. Can J Public Health 97(5):369–373

    PubMed  Google Scholar 

  • Schmidt JR, Elmansoury HK (1963) Natural and experimental infection of Egyptian equines with West Nile virus. Ann Trop Med Parasitol 57:415–427

    CAS  PubMed  Google Scholar 

  • Schneider BS, Higgs S (2008) The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune response. Trans R Soc Trop Med Hyg 102(5):400–408

    PubMed Central  PubMed  Google Scholar 

  • Schuffenecker I, Peyrefitte CN, el Harrak M, Murri S, Leblond A, Zeller HG (2005) West Nile virus in Morocco, 2003. Emerg Infect Dis 11(2):306–309

    PubMed Central  PubMed  Google Scholar 

  • Seino KK, Long MT, Gibbs EP, Bowen RA, Beachboard SE, Humphrey PP, Dixon MA, Bourgeois MA (2007) Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model. Clin Vaccine Immunol 14(11):1465–1471

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sejvar JJ, Marfin AA (2006) Manifestations of West Nile neuroinvasive disease. Rev Med Virol 16(4):209–224

    PubMed  Google Scholar 

  • Sejvar JJ, Haddad MB, Tierney BC, Campbell GL, Marfin AA, Van Gerpen JA, Fleischauer A, Leis AA, Stokic DS, Petersen LR (2003a) Neurologic manifestations and outcome of West Nile virus infection. JAMA 290(4):511–515

    Google Scholar 

  • Sejvar JJ, Leis AA, Stokic DS, Van Gerpen JA, Marfin AA, Webb R, Haddad MB, Tierney BC, Slavinski SA, Polk JL, Dostrow V, Winkelmann M, Petersen LR (2003b) Acute flaccid paralysis and West Nile virus infection. Emerg Infect Dis 9(7):788–793

    Google Scholar 

  • Sejvar JJ, Bode AV, Marfin AA, Campbell GL, Ewing D, Mazowiecki M, Pavot PV, Schmitt J, Pape J, Biggerstaff BJ, Petersen LR (2005) West Nile virus-associated flaccid paralysis. Emerg Infect Dis 11(7):1021–1027

    PubMed Central  PubMed  Google Scholar 

  • Sejvar JJ, Bode AV, Marfin AA, Campbell GL, Pape J, Biggerstaff BJ, Petersen LR (2006) West Nile virus-associated flaccid paralysis outcome. Emerg Infect Dis 12(3):514–516

    PubMed Central  PubMed  Google Scholar 

  • Sejvar JJ, Curns AT, Welburg L, Jones JF, Lundgren LM, Capuron L, Pape J, Reeves WC, Campbel GL (2008) Neurocognitive and functional outcomes in persons recovering from West Nile virus illness. J Neuropsychol 2(Pt 2):477–499

    PubMed  Google Scholar 

  • Sejvar JJ, Lindsey NP, Campbell GL (2011) Primary causes of death in reported cases of fatal West Nile fever, United States, 2002–2006. Vector Borne Zoonotic Dis 11(2):161–164

    PubMed  Google Scholar 

  • Shukla J, Saxena D, Rathinam S, Lalitha P, Joseph CR, Sharma S, Soni M, Rao PV, Parida M (2012) Molecular detection and characterization of West Nile virus associated with multifocal retinitis in patients from southern India. Int J Infect Dis 16(1):e53–59

    PubMed  Google Scholar 

  • Siger L, Bowen R, Karaca K, Murray M, Jagannatha S, Echols B, Nordgren R, Minke JM (2006) Evaluation of the efficacy provided by a Recombinant Canarypox-Vectored Equine West Nile Virus vaccine against an experimental West Nile Virus intrathecal challenge in horses. Vet Ther 7(3):249–256

    PubMed  Google Scholar 

  • Smithburn, KC, Hughes TP, Burke AW, Paul JH (1940) A neurotropic virus isolated from the blood of a native of Uganda. Am J Trop Med Hyg 20:470–492

    Google Scholar 

  • Smithburn KC, Jacobs HR (1942) Neutralization-tests against neurotropic viruses with sera collected in Central Africa. J Immunology 44(1):9–23

    Google Scholar 

  • Soliman A, Mohareb E, Salman D, Saad M, Salama S, Fayez C, Hanafi H, Medhat I, Labib E, Rakha M, El-Sayed N, Yingst S, Tjaden J, Earhart K (2010) Studies on West Nile virus infection in Egypt. J Infect Public Health 3(2):54–59

    PubMed  Google Scholar 

  • Solomon T (2004) Flavivirus encephalitis. N Engl J Med 351(4):370–378

    CAS  PubMed  Google Scholar 

  • Sondgeroth K, Blitvich B, Blair C, Terwee J, Junge R, Sauther M, VandeWoude S (2007) Assessing flavivirus, lentivirus, and herpesvirus exposure in free-ranging ring-tailed lemurs in southwestern Madagascar. J Wildl Dis 43(1):40–47

    CAS  PubMed  Google Scholar 

  • Sotelo E, Gutierrez-Guzman AV, Del Amo J, Llorente F, El-Harrak M, Perez-Ramirez E, Blanco JM, Hofle U, Jimenez-Clavero MA (2011) Pathogenicity of two recent Western Mediterranean West Nile virus isolates in a wild bird species indigenous to Southern Europe: the red-legged partridge. Vet Res 42(1):11

    PubMed Central  PubMed  Google Scholar 

  • Soverow JE, Wellenius GA, Fisman DN, Mittleman MA (2009) Infectious disease in a warming world: how weather influenced West Nile virus in the United States (2001–2005). Environ Health Perspect 117(7):1049–1052

    PubMed Central  PubMed  Google Scholar 

  • Steinman A, Banet-Noach C, Simanov L, Grinfeld N, Aizenberg Z, Levi O, Lahav D, Malkinson M, Perk S, Shpigel NY (2006) Experimental infection of common garter snakes (Thamnophis sirtalis) with West Nile virus. Vector Borne Zoonotic Dis 6(4):361–368

    PubMed  Google Scholar 

  • Styer LM, Lim PY, Louie KL, Albright RG, Kramer LD, Bernard KA (2011) Mosquito saliva causes enhancement of West Nile virus infection in mice. J Virol 85(4):1517–1527

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sutherland LJ, Cash AA, Huang YJ, Sang RC, Malhotra I, Moormann AM, King CL, Weaver SC, King CH, LaBeaud AD (2011) Serologic evidence of arboviral infections among humans in Kenya. Am J Trop Med Hyg 85(1):158–161

    PubMed Central  PubMed  Google Scholar 

  • Taylor RM, Work TH, Hurlbut HS, Rizk F (1956) A study of the ecology of West Nile virus in Egypt. Am J Trop Med Hyg 5(4):579–620

    PubMed  Google Scholar 

  • Tesh RB, Parsons R, Siirin M, Randle Y, Sargent C, Guzman H, Wuithiranyagool T, Higgs S, Vanlandingham DL, Bala AA, Haas K, Zerinque B (2004) Year-round West Nile virus activity, Gulf Coast region, Texas and Louisiana. Emerg Infect Dis 10(9):1649–1652

    PubMed Central  PubMed  Google Scholar 

  • Tesh RB, Siirin M, Guzman H, Travassos da Rosa AP, Wu X, Duan T, Lei H, Nunes MR, Xiao SY (2005) Persistent West Nile virus infection in the golden hamster: studies on its mechanism and possible implications for other flavivirus infections. J Infect Dis 192(2):287–295

    PubMed  Google Scholar 

  • Thakare JP, Rao TL, Padbidri VS (2002) Prevalence of West Nile virus infection in India. Southeast Asian J Trop Med Public Health 33(4):801–805

    CAS  PubMed  Google Scholar 

  • Tilley PA, Fox JD, Jayaraman GC, Preiksaitis JK (2006) Nucleic acid testing for West Nile virus RNA in plasma enhances rapid diagnosis of acute infection in symptomatic patients. J Infect Dis 193(10):1361–1364

    CAS  PubMed  Google Scholar 

  • Touil N, Cherkaoui Z, Lmrabih Z, Loutfi C, Harif B, El Harrak M (2012) Emerging viral diseases in dromedary camels in the Southern Morocco. Transbound Emerg Dis 59(2):177–182

    CAS  PubMed  Google Scholar 

  • Triki H, Murri S, Le Guenno B, Bahri O, Hili K, Sidhom M, Dellagi K (2001) West Nile viral meningo-encephalitis in Tunisia. Med Trop (Mars) 61(6):487–490

    CAS  Google Scholar 

  • Tsai TF, Popovici F, Cernescu C, Campbell GL, Nedelcu NI (1998) West Nile encephalitis epidemic in southeastern Romania. Lancet 352(9130):767–771

    CAS  PubMed  Google Scholar 

  • Valiakos G, Touloudi A, Athanasiou LV, Giannakopoulos A, Iacovakis C, Birtsas P, Spyrou V, Dalabiras Z, Petrovska L, Billinis C (2012) Serological and molecular investigation into the role of wild birds in the epidemiology of West Nile virus in Greece. Virol J 9:266

    PubMed Central  PubMed  Google Scholar 

  • Vazquez A, Sanchez-Seco MP, Ruiz S, Molero F, Hernandez L, Moreno J, Magallanes A, Tejedor CG, Tenorio A (2010) Putative new lineage of West Nile virus, Spain. Emerg Infect Dis 16(3):549–552

    PubMed Central  PubMed  Google Scholar 

  • Venter M (2009) Lineage 2 West Nile virus as cause of fatal neurologic disease in horses, South Africa. Emerg Infect Dis 15(6):659–664

    Google Scholar 

  • Venter M, Swanepoel R (2010) West Nile virus lineage 2 as a cause of zoonotic neurological disease in humans and horses in southern Africa. Vector Borne Zoonotic Dis 10(7):659–664

    PubMed  Google Scholar 

  • Verma S, Lo Y, Chapagain M, Lum S, Kumar M, Gurjav U, Luo H, Nakatsuka A, Nerurkar VR (2009) West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: transmigration across the in vitro blood-brain barrier. Virology 385(2):425–433

    CAS  PubMed Central  PubMed  Google Scholar 

  • Wang G, Minnis RB, Belant JL, Wax CL (2010) Dry weather induces outbreaks of human West Nile virus infections. BMC Infect Dis 10:38

    PubMed Central  PubMed  Google Scholar 

  • Wang H, Siddharthan V, Hall JO, Morrey JD (2009) West Nile virus preferentially transports along motor neuron axons after sciatic nerve injection of hamsters. J Neurovirol 1–7

    Google Scholar 

  • Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA (2004) Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 10(12):1366–1373

    CAS  PubMed  Google Scholar 

  • Ward MP, Levy M, Thacker HL, Ash M, Norman SK, Moore GE, Webb PW (2004) Investigation of an outbreak of encephalomyelitis caused by West Nile virus in 136 horses. J Am Vet Med Assoc 225(1):84–89

    PubMed  Google Scholar 

  • Watson JT, Pertel PE, Jones RC, Siston AM, Paul WS, Austin CC, Gerber SI (2004) Clinical characteristics and functional outcomes of West Nile fever. Ann Intern Med 141(5):360–365

    PubMed  Google Scholar 

  • Weber IB, Lindsey NP, Bunko-Patterson AM, Briggs G, Wadleigh TJ, Sylvester TL, Levy C, Komatsu KK, Lehman JA, Fischer M, Staples JE (2011) Completeness of West Nile virus testing in patients with meningitis and encephalitis during an outbreak in Arizona, USA. Epidemiol Infect 140(9):1632–1636

    PubMed  Google Scholar 

  • Weinberger M, Pitlik SD, Gandacu D, Lang R, Nassar F, Ben David D, Rubinstein E, Izthaki A, Mishal J, Kitzes R, Siegman-Igra Y, Giladi M, Pick N, Mendelson E, Bin H, Shohat T (2001) West Nile fever outbreak, Israel, 2000: epidemiologic aspects. Emerg Infect Dis 7(4):686–691

    CAS  PubMed Central  PubMed  Google Scholar 

  • Weingartl HM, Neufeld JL, Copps J, Marszal P (2004) Experimental West Nile virus infection in blue jays (Cyanocitta cristata) and crows (Corvus brachyrhynchos). Vet Pathol 41(4):362–370

    CAS  PubMed  Google Scholar 

  • Wimberly MC, Hildreth MB, Boyte SP, Lindquist E, Kightlinger L (2008) Ecological niche of the 2003 West Nile virus epidemic in the northern great plains of the United States. PLoS One 3(12):e3744

    PubMed Central  PubMed  Google Scholar 

  • Work TH, Hurlbut HS, Taylor RM (1955) Indigenous wild birds of the Nile Delta as potential West Nile virus circulating reservoirs. Am J Trop Med Hyg 4(5):872–888

    CAS  PubMed  Google Scholar 

  • Zaayman D, Venter M (2012) West Nile virus neurologic disease in humans, South Africa, September 2008-may 2009. Emerg Infect Dis 18(12):2051–2054

    PubMed Central  PubMed  Google Scholar 

  • Ziegler U, Angenvoort J, Fischer D, Fast C, Eiden M, Rodriguez AV, Revilla-Fernandez S, Nowotny N, de la Fuente JG, Lierz M, Groschup MH (2013) Pathogenesis of West Nile virus lineage 1 and 2 in experimentally infected large falcons. Vet Microbiol 161(3–4):263–273

    CAS  PubMed  Google Scholar 

  • Zohrabian A, Hayes EB, Petersen LR (2006) Cost-effectiveness of West Nile virus vaccination. Emerg Infect Dis 12(3):375–380

    PubMed Central  PubMed  Google Scholar 

  • Zou S, Foster GA, Dodd RY, Petersen LR, Stramer SL (2010) West Nile fever characteristics among viremic persons identified through blood donor screening. J Infect Dis 202(9):1354–1361

    PubMed  Google Scholar 

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    Lyle R. Petersen MD

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    Andreas Sing

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Petersen, L. (2015). West Nile Virus: From Africa to Europe, America, and Beyond. In: Sing, A. (eds) Zoonoses - Infections Affecting Humans and Animals. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9457-2_38

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