Skip to main content

Carbon Nanotubes and Safety

Classification of Carbon Nanotubes, Size Effects and Potential Toxicity of the High-Aspect Ratio Nanotubes

  • Chapter
  • First Online:
Trends in Nanoscale Mechanics

Abstract

This chapter reviews geometry of different classes of carbon nanotubes and examines similarities between carbon nanotubes and asbestos fibers. Geometric parameters of carbon nanotubes are characterized by the aspect ratios and other critical scaling parameters related to the inhalability of carbon nanotubes and their engulfment by macrophages in phagocytosis. Geometric and scaling parameters are used to present a conceptual framework and a parametric map for the extrapolation of potential toxic effects resulting from the inhalation of carbon nanotubes. Similarities between carbon nanotubes and asbestos fibers are also examined by using the Cook’s criteria for the asbestos-like pathologies that can be also caused by microscopic fibers. Scaling parameters for the size effects associated with carbon nanotubes and a new parametric map for the efficiency of phagocytosis are used to evaluate the potential toxicological effects of the inhaled carbon nanotubes from the point of view of the Cook’s criteria for asbestos fibers and other research.

Dr. V.M. Harik, f. ICASE Staff Scientist at the NASA Langley Research Center (Hampton, VA), Principal Scientist at Nanodesign Consulting, author of a monograph and a short course entitled “Mechanics of Carbon Nanotubes” © (2001) presented at the Annual ASME Congress (2001 & 2004) and a co-editor of Kluwer volumes: “Trends in Nanoscale Mechanics” (2003) and “Micromechanics and Nanoscale Effects” (2004).

Nanodesigns Consulting is a 2004 spin-off from the NASA Langley Research Center, Hampton, Virginia. Its Staff consulted for the Princeton-based NASA-funded URETI Institute for Nanostructured Bio-inspired Materials (http://bimat.org), National Institute of Aerospace (Hampton, VA), University Space Research Association (USRA) and NASA NAIC (Atlanta, GA).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    R. Hurt, Which material properties/features determine the biological response to carbon nanotubes? Brown University, Providence, Rhode Island, 2011.

References

  1. The Royal Academy of Engineering and the British Royal Society, Nanoscience and Nanotechnologies: Opportunities and Uncertainties (Joint Report, the Royal Academy of Engineering and the British Royal Society, London, United Kingdom, August 2004)

    Google Scholar 

  2. P.M. Cook, Asbestos and Related Durable Fibers: Too Ubiquitous, Too Persistent, Too Complex to Put Health Risks to Rest? (Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Duluth, Minnesota, 2004)

    Google Scholar 

  3. V.M. Harik, Nanotechnology of Carbon Nanotubes and Safety Issues (Proceedings of the 20th Technical Conference of American Society for Composites, Philadelphia, Pennsylvania, 7–8 September 2005), p. 44

    Google Scholar 

  4. V.M. Harik, Ranges of Applicability for the Continuum-Beam Model in the Constitutive Analysis of Carbon Nanotubes: Nanotubes or Nano-Beams? (NASA/CR-2001-211013, NASA Langley Research Center, Hampton, Virginia, USA, June 2001)

    Google Scholar 

  5. V.M. Harik, Ranges of applicability of the continuum beam model in the mechanics of carbon nanotubes. Solid State Commun. (Int. J.) 120, 331–335 (2001)

    Google Scholar 

  6. V.M. Harik, Mechanics of Carbon Nanotubes (A Short Course Notes) (ASME Education Institute, American Society of Mechanical Engineers, New York, NY, USA, 2001)

    Google Scholar 

  7. V.M. Harik, Comput. Mater. Eng. (Int. J.) 24(3), 328 (2002)

    Google Scholar 

  8. S.J.V. Frankland, V.M. Harik, Analysis of carbon nanotube pull-out from a polymer matrix. Surf. Sci. Lett. 525, L103 (2003)

    Google Scholar 

  9. S.J.V. Frankland, V.M. Harik, Mat. Res. Soc. Symp. Proc. 733 E, T6.2.1 (2002)

    Google Scholar 

  10. S.J.V. Frankland, V.M. Harik, Mat. Res. Soc. Symp. Proc. 740, I12.1.1 (2002)

    Google Scholar 

  11. D.B. Warheit, B.R. Laurence, K.L. Reed, D.H. Roach, G.A.M. Reynolds, T.R. Webb, Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci. 77, 117–125 (2004)

    Article  Google Scholar 

  12. C.-W. Lam, J.T. James, R. McCluskey, R.L. Hunter, Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instilation. Toxicol. Sci. 77, 126–134 (2004)

    Article  Google Scholar 

  13. J. Muller, F. Huaux, N. Moreau, P. Misson, J.F. Heilier, M. Delos et al., Respiratory toxicity of multi-wall carbon nanotubes. Toxicol. Appl. Pharmacol. 207(3), 221–31 (2005)

    Article  Google Scholar 

  14. L.E. Murr, K.M. Garza, K.F. Soto, A. Carrasco, T.G. Powell, D.A. Ramirez et al., Cytotoxicity assessment of some carbon nanotubes and related carbon nanoparticle aggregates and the implications for anthropogenic carbon nanotube aggregates in the environment. Int. J. Environ. Res. Public Health 2(1), 31–42 (2005)

    Article  Google Scholar 

  15. A.A. Shvedova, V. Castranova, E.R. Kisin, A.R. Murray, D. Schwegler-Berry, V.Z. Gandelsman, A. Maynard, P. Baron. Exposure to nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells (Multiscale analysis of cells and other materials systems has been presented in V.M. Harik, M. Salas (eds.) Trends in Nanoscale Mechanics (Kluwer Academic Publishers, The Netherlands, 2003), while various transport phenomena in ionic fluids have been examined in V.M. Harik, L.-S. Luo (eds.), Micromechanics and Nanoscale Effects (Kluwer Academic Publishers, The Netherlands, 2004)). J. Toxicol. Environ. Health 66, 1901–1918 (2003)

    Google Scholar 

  16. V. Stone, K. Donaldson, Signs of stress (“Signs of stress” refers to the situation when 500 µm cell tried to digest carbon nanotubes without success). Nature 1, 23–24 (2006)

    Google Scholar 

  17. K. Kostarelos, The long and short of carbon nanotube toxicity, (The “long and short” sized nanotube toxicity depends on geometric parameters of carbon nanotubes.) Nat. Biotechnol. 28(7), 774–776 (2008)

    Google Scholar 

  18. M.-C.F. Jaurand, A. Renier, J. Daubriac, Mesothelioma: do asbestos and carbon nanotubes pose the same health risk? Part. Fibre Toxicol. 6(16), 1–14 (2009)

    Google Scholar 

  19. C.A. Poland, R. Duffin, I. Kinloch, A. Maynard, W.A. Wallace, A. Seaton, V. Stone, S. Brown, W. Macnee, K. Donaldson, Carbon nanotubes introduced into the abdominal cavity of mice show asbestos like pathogenicity in a pilot study. Nat. Nanotechnol. 3, 423–428 (2008)

    Article  Google Scholar 

  20. K. Donaldson, F.A Murphy, R. Duffin, C.A Poland, Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part. Fibre Toxicol. 7(5), 1–17 (2010)

    Google Scholar 

  21. K. Yamashita, Y. Yoshioka, K. Higashisaka et al., Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape. Inflammation 33(4), 276–280 (2010)

    Article  Google Scholar 

  22. V.M. Harik, Mechanics of Carbon Nanotubes (Nanodesigns Press, Newark, Delaware, 2011)

    Google Scholar 

  23. B. Diskin, V.M. Harik, Efficient multigrid methods for materials processing flows with small particles: effects of particle distribution and processing conditions, Chapter 5, in Micromechanics and Nanoscale Effects, ed. by V.M. Harik, L.-S. Luo (Kluwer Academic Publishers, The Netherlands, 2004)

    Google Scholar 

  24. C. Salvador-Morales, P. Townsend, E. Flahaut, C. Ve´nien-Bryan, A. Vlandas, M.L.H. Green, R.B. Sim, Binding of pulmonary surfactant proteins to carbon nanotubes; potential for damage to lung immune defense mechanisms. Carbon 45, 607–617 (2007)

    Google Scholar 

Further Readings

  1. D.W. Cugell, D.W. Kamp, Asbestos and the pleura: a review. Chest 125, 1103–1117 (2004)

    Google Scholar 

  2. S.J. Lai-Fook, Pleural mechanics and fluid exchange. Physiol. Rev. 84, 385–410 (2004)

    Google Scholar 

  3. J. Liu, H.L. Wong, J. Moselhy, B. Bowen, X.Y. Wu, M.R. Johnston, Targeting colloidal particulates to thoracic lymph nodes. Lung Cancer 51, 377–386 (2006)

    Article  Google Scholar 

  4. I. Ahmad, G. Hsuan, C. Li, R. Cairncross, Reaction-diffusion model describing antioxidant depletion in polyethylene-clay nanocomposites, in Abstracts of the 2013 AIChE Annual Meeting on Environmental Aspects, Applications, and Implications of Nanomaterials and Nanotechnology (San Francisco, CA, 2013)

    Google Scholar 

Download references

Acknowledgments

This research has been supported in part by the Nanotech Safety Program at Nanodesigns Consulting (http://www.nanodesignconsult.com), which encourages all researchers to allocate at least 5 % of the research funding for ensuring and improving the safety of nanotechnology in their area of research.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vasyl Harik .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Harik, V. (2014). Carbon Nanotubes and Safety. In: Harik, V. (eds) Trends in Nanoscale Mechanics. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9263-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-9263-9_8

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-9262-2

  • Online ISBN: 978-94-017-9263-9

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics