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Regulation of Heat Shock Genes Expression

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Heat Shock Proteins and Whole Body Adaptation to Extreme Environments

Abstract

Cellular stresses modulate intracellular signaling pathways that control almost all aspects of cell physiology and metabolism. Heat shock genes system activation in response to various forms of stress is extremely rapid and, hence, represents an excellent model for investigation of gene regulation at all levels. In Drosophila it is possible to detect local chromatin decondensation leading to puffs formation in salivary glands polytene chromosomes within the first 1–2 min after HS challenge. Fast activation of Hsp genes is apparently necessary for cell survival under stress conditions and for cross-protection against unrelated stresses. Activation of HS system is rapidly initiated at all stages of genetic information realization including transcription, export of mRNA and translation.

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  1. Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, Russia

    Michael B. Evgen’ev, David G. Garbuz & Olga G. Zatsepina

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  1. Michael B. Evgen’ev
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  2. David G. Garbuz
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  3. Olga G. Zatsepina
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© 2014 Springer Science+Business Media Dordrecht

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Evgen’ev, M.B., Garbuz, D.G., Zatsepina, O.G. (2014). Regulation of Heat Shock Genes Expression. In: Heat Shock Proteins and Whole Body Adaptation to Extreme Environments. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9235-6_3

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