Skip to main content
SpringerLink
Log in

Capsule Endoscopy in Pediatrics

  • Chapter
  • First Online:
Book cover Handbook of Capsule Endoscopy

Abstract

Small bowel capsule endoscopy (SBCE ) becomes particularly valuable for pediatric patients because it does not require the ionizing radiation, deep sedation, or general anesthesia usually employed by other imaging modalities. In light of these features supportive data, the US Food and Drug Administration (FDA) expanded the role of SBCE for use in children aged 2 years and older and approved the use of a patency capsule (PC) for this age group.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. U.S. Food and Drug Administration, Center for Devices and Radiological Health. PC Patency system and pillcam platform with pillcam SB capsules. Available at: http://www.accessdata.fda.gov/cdrh_docs/pdf9/K090557.pdf. Accessed 10 Feb 2010.

  2. Mishkin DS, Chuttani R, Croffie J, et al. ASGE technology status evaluation report: wireless capsule endoscopy. Gastrointest Endosc. 2006;63:539–45.

    Article  PubMed  Google Scholar 

  3. Cohen SA, Klevens AI. Use of capsule endoscopy in diagnosis and management of pediatric patients, based on meta-analysis. Clin Gastroenterol Hepatol. 2011;9:490–6.

    Article  PubMed  Google Scholar 

  4. Cohen SA, Ephrath H, Lewis JD, et al. Pediatric capsule endoscopy: a single center, 5 year retrospective review of small bowel and patency capsules. JPGN. 2012;54:409–13.

    PubMed  Google Scholar 

  5. Gralnek IM, Cohen SA, Ephrath H. Small bowel capsule endoscopy impacts diagnosis and management of pediatric inflammatory bowel disease: a prospective study. Digest Dis Sci. DOI 10.1007/s10620-011-1894-5.

  6. Tokuhara D, Watanabe K, Okano Y, et al. Wireless capsule endoscopy in pediatric patients: the first series from Japan. J Gastroenterol. 2010;45:683–91.

    Article  PubMed  Google Scholar 

  7. Guilhon de Araujo Sant’Anna AM, Dubois J, Miron MC, et al. Wireless capsule endoscopy for obscure small-bowel disorders: final results of the first pediatric controlled trial. Clin Gastroenterol Hepatol 2005;3:264–270.

    Google Scholar 

  8. Jensen MK, Tipnis NA, Bajorunaite R, et al. Capsule endoscopy performed across the pediatric age range: indications, incomplete studies, and utility in management of inflammatory bowel disease. Gastrointest Endosc. 2010;72:95–102.

    Article  PubMed  Google Scholar 

  9. Antao B, Bishop J, Shawis R, et al. Clilnical application and diagnostic yield of wireless capsule endoscopy in children. J Laparoendosc Adv Surg Tech. 2007;17:364–70.

    Article  Google Scholar 

  10. Cohen SA, Gralnek IM, Ephrath H, et al. Capsule endoscopy may reclassify pediatric inflammatory bowel disease: a historical analysis. J Pediatr Gastroenterol Nutr. 2008;47:31–6.

    Article  PubMed  Google Scholar 

  11. de’ Angelis GL, Fornaroli F, de’ Angeles N, et al. Wireless capsule endoscopy for pediatric small-bowel diseases. Am J Gastroenterol 2007;102:1749–1757.

    Google Scholar 

  12. Atay O, Mahajan L, Kay M, et al. Risk of capsule endoscope retention in pediatric patients: a large single-center experience and review of the literature. J Pediatr Gastroenterol Nutr. 2009;49:1–6.

    Article  Google Scholar 

  13. Cohen S. Pediatric capsule endoscopy. Tech Gastrointest Endosc. 2013;15:32–5.

    Article  Google Scholar 

  14. Moy L, Levine J. Wireless capsule endoscopy in the pediatric age group: experience and complications. J Pediatr Gastroenterol Nutr. 2007;44:516–20.

    Article  PubMed  Google Scholar 

  15. Ge ZZ, Chen HY, Gao YJ, et al. Clinical application of wireless capsule endoscopy in pediatric patients for suspected small bowel diseases. Eur J Pediatr. 2007;166:825–9.

    Article  PubMed  Google Scholar 

  16. Arguelles-Arias F, Caunedo A, Romero J, et al. The value of capsule endoscopy in pediatric patients with a suspicion of Crohn’s disease. Endoscopy. 2004;36:869–73.

    Article  CAS  PubMed  Google Scholar 

  17. Urbain D, Tresinie M, De Looze D, et al. Capsule endoscopy in paediatrics: multicentric Belgian study. Acta Gastroenterol Belg. 2007;70:11–4.

    PubMed  Google Scholar 

  18. Barth BA, Donovan K, Fox VL. Endoscopic placement of the capsule endoscope in children. Gastrointest Endosc. 2004;60:818–21.

    Article  PubMed  Google Scholar 

  19. Shamir R, Hino B, Hartman C, et al. Wireless video capsule in pediatric patients with functional abdominal pain. J Pediatr Gastroenterol Nutr. 2007;44:45–50.

    Article  CAS  PubMed  Google Scholar 

  20. Fritscher-Ravens A, Scherbakov P, Bufler P, et al. The feasibility of wireless capsule endoscopy in detecting small intestinal pathology in children under the age of 8 years: a multicentre European study. Gut. 2009;58:1467–72.

    Article  CAS  PubMed  Google Scholar 

  21. Postgate A, Hyer W, Phillips R, et al. Feasibility of video capsule endoscopy in the management of children with Peutz-Jeghers Syndrome: a blinded comparison with barium enterography for the detection of small bowel polyps. J Pediatr Gastroenterol Nutr. 2009;49:417–23.

    Article  PubMed  Google Scholar 

  22. Thomson M, Fritscher-Ravens A, Mylonaki M, et al. Wireless capsule endoscopy in children: a study to assess diagnostic yield in small bowel disease in pediatric patients. J Pediatr Gastroenterol Nutr. 2007;44:192–7.

    Article  PubMed  Google Scholar 

  23. Werlin SL, Benuri-Silbiger I, Kerem E, et al. Evidence of intestinal inflammation in patients with cystic fibrosis. JPGN. 2010;51:304–8.

    CAS  PubMed  Google Scholar 

  24. Cohen SA, Lewis J, Stallworth A, et al. Mucosal healing with the specific carbohydrate diet in pediatric Crohn’s disease: preliminary results of a 12 week pilot study. Gastroenterol 2012;142(5):Supp AB Sa1992.

    Google Scholar 

  25. Viazis N, Sgouros S, Papaxoinis K, et al. Bowel preparation increases the diagnostic yield of capsule endoscopy: a prospective, randomized, controlled study. Gastrointest Endosc. 2004;60:534–8.

    Article  PubMed  Google Scholar 

  26. Burke CA, Church JM. Enhancing the quality of colonoscopy: the importance of bowel purgatives. Gastrointest Endosc. 2007;66:565–73.

    Article  PubMed  Google Scholar 

  27. de Franchis R, Avgerinos A, Barkin J, et al. ICCE consensus for bowel preparation and prokinetics. Endoscopy. 2005;37:1040–5.

    Article  PubMed  Google Scholar 

  28. Mergener K, Ponchon T, Gralnek I, et al. Literature review and recommendations for clinical application of small-bowel capsule endoscopy, based on a panel discussion by international experts. Consensus statements for small-bowel capsule endoscopy, 2006/2007. Endoscopy. 2007;39:895–909.

    Article  CAS  PubMed  Google Scholar 

  29. Dai N, Gubler C, Hengstler P, et al. Improved capsule endoscopy after bowel preparation. Gastrointest Endosc. 2005;61:28–31.

    Article  PubMed  Google Scholar 

  30. Ladas SD, Triantafyllou K, Spada C, et al. ESGE recommendations on VCE in investigation of small-bowel, esophageal, and colonic diseases. Endoscopy. 2010;42:220–7.

    Article  CAS  PubMed  Google Scholar 

  31. van Tuyl SA, den Ouden H, Stolk MF, et al. Optimal preparation for video capsule endoscopy: a prospective, randomized, single-blind study. Endoscopy. 2007;39:1037–40.

    Article  PubMed  Google Scholar 

  32. Wei W, Ge ZZ, Lu H, et al. Purgative bowel cleansing combined with simethicone improves capsule endoscopy imaging. Am J Gastroenterol. 2008;103:77–82.

    Article  PubMed  Google Scholar 

  33. Ben Soussan E, Savoye G, Antonietti M, et al. Is a 2-liter PEG preparation useful before capsule endoscopy? J Clin Gastroenterol. 2005;2005(39):381–4.

    Article  Google Scholar 

  34. Mishkin DS, Chuttani R, Croffie J, et al. ASGE technology status evaluation report: wireless capsule endoscopy. Gastrointest Endosc. 2006;63:539–45.

    Article  PubMed  Google Scholar 

  35. Faigel DO, Baron TH, Adler DG, et al. ASGE guideline: guidelines for credentialing and granting privileges for capsule endoscopy. Gastrointest Endosc. 2005;61:503–5.

    Article  PubMed  Google Scholar 

  36. Villa F, Signorelli C, Rondonotti E, et al. Preparations and prokinetics. Gastrointest Endosc Clin N Am. 2006;16:211–20.

    Article  PubMed  Google Scholar 

  37. Spada C, Riccioni ME, Familiari P, et al. Polyethylene glycol plus simethicone in small-bowel preparation for capsule endoscopy. Dig Liver Dis. 2010;42:365–7.

    Article  CAS  PubMed  Google Scholar 

  38. Chen H, Huang Y, Che S, et al. Small bowel preparations for capsule endoscopy with mannitol and simethicone: a prospective, randomized, clinical trial. J Clin Gastroenterol. 2011;45:337–41.

    Article  CAS  PubMed  Google Scholar 

  39. Oliva S, Cucchiara S, Spada C, et al. Small bowel cleansing for capsule endoscopy in pediatric patients: a prospective randomized single-blinded study. Dig Liver Dis. 2014;45:51–5.

    Article  Google Scholar 

  40. Malagelada C, DeIorio F, Azpiroz F, et al. New insight into intestinal motor function via noninvasive endoluminal image analysis. J Gastroenterol. 2008;135:1155–62.

    Article  Google Scholar 

  41. Fireman Z, Mahajana E, Broide E, et al. Diagnosing small bowel Crohn’s disease with wireless capsule endoscopy. Gut. 2003;52:390–2.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  42. Liao Z, Gao R, Xu C, Zhao-Shen L. Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review. Gastrointest Endosc. 2010;71:280–6.

    Article  PubMed  Google Scholar 

  43. Gay G, Fassler I, Florent C, Delvaux M. Malabsorption. In: Halpern M, Jacob H, editors. Atlas of capsule endoscopy. Norcross, GA: Given Imaging; 2002. p. 84–90.

    Google Scholar 

  44. Murray JA, Rubio-Tapia A, Van Dyke CT, et al. Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment. Clin Gastroenterol Hepatol. 2008;6:186–93.

    Article  PubMed Central  PubMed  Google Scholar 

  45. Uko V, Atay O, Mashajan L, et al. Endoscopic deployment of the wireless capsule using a capsule delivery device in pediatric patients: a case series. Endoscopy. 2009;41:380–2.

    Article  CAS  PubMed  Google Scholar 

  46. Cohen SA, Gralnek IM, Ephrath H, et al. The use of a patency capsule in pediatric Crohn’s disease: a prospective evaluation. Dig Dis Sci. 2011;56(3):860–5.

    Article  PubMed  Google Scholar 

  47. Fox V. Esophageal capsule endoscopy in children and young adults with portal hypertension. 6th International Conference on Capsule Endoscopy (ICCE) 2006;Madrid:AB887874.

    Google Scholar 

  48. Schaible TD, Olive AP, Wilson DS, et al. Use of esophageal capsule endoscopy in pediatric patients with portal hypertension. Gastrointest Endosc. 2010;71(5):M1562.

    Google Scholar 

  49. De Franchis R, Eisen GM, Laine L, et al. Esophageal capsule endoscopy for screening and surveillance of esophageal varices in patients with portal hypertension. Hepatology. 2008;47:1595–603.

    Article  PubMed  Google Scholar 

  50. Schoofs N, Deviere J, Van Gossum A, et al. PillCam colon capsule endoscopy compared with colonoscopy for colorectal tumor diagnosis: a prospective pilot study. Endoscopy. 2006;38:971–7.

    Article  CAS  PubMed  Google Scholar 

  51. Van Gossum A, Navas MM, Fernandez-Urien I, et al. Capsule endoscopy versus colonoscopy for the detection of polyps and cancer. N Engl J Med. 2009;361:264–70.

    Article  PubMed  Google Scholar 

  52. Eliakim R, Yassin K, Niv Y, et al. Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy. Endoscopy. 2009;41:1026–31.

    Article  CAS  PubMed  Google Scholar 

  53. Spada C, Hassan C, Munoz-NavasMet al. Second-generation colon capsule compared with colonoscopy. Gastrointest Endosc 2011;74:581–589 e1. Erratum in Gastrointest Endosc 2011;74:1174.

    Google Scholar 

  54. Spada C, Hassan C, Munoz-NavasMet al. Second-generation colon capsule compared with colonoscopy. Gastrointest Endosc 2011;74:581–589 e1. Erratum in Gastrointest Endosc 2011;74:1174.

    Google Scholar 

  55. Spada C, Hassan C, Galmiche JP, et al. Colon capsule endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2012;44:527–36.

    Article  CAS  PubMed  Google Scholar 

  56. Sung J, Ho KY, Chiu HM, et al. The use of pillcam colon in assessing mucosal inflammation in ulcerative colitis: a multicenter study. Endoscopy. 2012;44:754–8.

    Article  CAS  PubMed  Google Scholar 

  57. Ye CA, Gao YJ, Ge ZZ, et al. PillCam colon capsule endoscopy versus conventional colonoscopy for the detection of severity and extent of ulcerative colitis. J Dig Dis. 2013;14:117–24.

    Article  CAS  PubMed  Google Scholar 

  58. Meister T, Heinzow HS, Domagk D, et al. Colon capsule endoscopy versus standard colonoscopy in assessing disease activity of ulcerative colitis: a prospective trial. Tech Coloproctol. 2013;17(6):641–6.

    Article  CAS  PubMed  Google Scholar 

  59. Hosoe N, Matsuoka K, Naganuma M, et al. Applicability of second generation colon capsule endoscope to ulcerative colitis: a clinical feasibility study. J Gastroenterol Hepatol. 2013;28(7):1174–9.

    Article  CAS  PubMed  Google Scholar 

  60. Oliva S, Di Nardo G, Hassan C et al. Second generation colon capsule endoscopy versus colonoscopy in pediatric ulcerative colitis: a pilot study. Endoscopy. 2014;46(6):485–92.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy

    Salvatore Oliva

  2. Children’s Center for Digestive Health Care, Atlanta, GA, USA

    Stanley Cohen

Authors
  1. Salvatore Oliva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stanley Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Salvatore Oliva .

Editor information

Editors and Affiliations

  1. Department of Gastroenterology, Changhai Hospital, Shanghai, China

    Zhaoshen Li

  2. Department of Gastroenterology, Changhai Hospital, Shanghai, China

    Zhuan Liao

  3. Gastroenterology, Royal Hallamshire Hospital, Sheffield, United Kingdom

    Mark McAlindon

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Oliva, S., Cohen, S. (2014). Capsule Endoscopy in Pediatrics. In: Li, Z., Liao, Z., McAlindon, M. (eds) Handbook of Capsule Endoscopy. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9229-5_7

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-9229-5_7

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-9228-8

  • Online ISBN: 978-94-017-9229-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation