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p53: Its Mutations and Their Impact on Transcription

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Mutant p53 and MDM2 in Cancer

Part of the book series: Subcellular Biochemistry ((SCBI,volume 85))

Abstract

p53 is a tumor suppressor protein whose key function is to maintain the integrity of the cell. Mutations in p53 have been found in up to 50 % of all human cancers and cause an increase in oncogenic phenotypes such as proliferation and tumorigenicity. Both wild-type and mutant p53 have been shown to transactivate their target genes, either through directly binding to DNA, or indirectly through protein-protein interactions. This review discusses possible mechanisms behind both wild-type and mutant p53-mediated transactivation and touches on the concept of addiction to mutant p53 of cancer cells and how that may be used for future therapies.

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Authors and Affiliations

  1. Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA, 23298, USA

    Catherine Vaughan, Isabella Pearsall & Andrew Yeudall

  2. Integrated Life Sciences Program, Virginia Commonwealth University, 1000 West Cary Street, Richmond, VA, 23284, USA

    Catherine Vaughan

  3. Department of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, 1101 East Leigh Street, Richmond, VA, 23298, USA

    Andrew Yeudall

  4. Department of Biochemistry and Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA

    Swati Palit Deb & Sumitra Deb

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  1. Department of Biochemistry and Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA

    Swati Palit Deb

  2. Department of Biochemistry and Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA

    Sumitra Deb

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Vaughan, C., Pearsall, I., Yeudall, A., Deb, S.P., Deb, S. (2014). p53: Its Mutations and Their Impact on Transcription. In: Deb, S., Deb, S. (eds) Mutant p53 and MDM2 in Cancer. Subcellular Biochemistry, vol 85. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9211-0_4

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