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Integrin α11β1: A Major Collagen Receptor on Fibroblastic Cells

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I Domain Integrins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 819))

Abstract

Integrin α11 is the last addition to the vertebrate integrin family. In this chapter we will summarize some basic facts about this integrin and update with information that has been gained in the last decade. Integrin α11β1 is a major collagen receptor on a subset of fibroblasts. Extensive characterization of the expression pattern in developing mouse embryos has demonstrated expression restricted to subsets of fibroblasts and a transient expression in odontoblasts, but comprehensive characterization of corresponding expression in adult tissues is still lacking. Mice lacking integrin α11 are dwarfed, primarily due to defective incisor eruption defect, which can be traced back to need for α11 on periodontal ligament fibroblasts during incisor eruption. Separate studies have suggested reduced levels of IGF-1 in mice lacking α11. Analysis of lung cancer has identified α11β1 as a functional important collagen receptor on carcinoma associated fibroblasts (CAFs) and a number of disease models are awaiting analysis to see the importance of this collagen receptor in pathological models.

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Authors and Affiliations

  1. Department of Biomedicine and Centre for Cancer Biomarkers, Norwegian Centre of Excellence, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway

    Cédric Zeltz, Ning Lu & Donald Gullberg

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  1. Cédric Zeltz
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  2. Ning Lu
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  3. Donald Gullberg
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Correspondence to Donald Gullberg .

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  1. University of Bergen, Bergen, Norway

    Donald Gullberg

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Zeltz, C., Lu, N., Gullberg, D. (2014). Integrin α11β1: A Major Collagen Receptor on Fibroblastic Cells. In: Gullberg, D. (eds) I Domain Integrins. Advances in Experimental Medicine and Biology, vol 819. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9153-3_5

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