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Integrin α10β1: A Collagen Receptor Critical in Skeletal Development

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Book cover I Domain Integrins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 819))

Abstract

Integrin α10β1 is the most abundant collagen-binding integrin in cartilaginous tissues and its expression pattern is distinct from that of other collagen-binding integrins. In vitro and in vivo studies have identified integrin α10β1 as a unique phenotypic marker for chondrocyte differentiation and a crucial mediator of cell-matrix interactions required for proper cartilage development. This chapter describes the structure of the integrin subunit α10, the tissue distribution of the integrin 10β1 and updates available information regarding its regulation and ligand binding. We also summarize current information on the functional roles of α10β1 in chondrogenesis of mesenchymal stem cells and in skeletal growth.

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Author information

Authors and Affiliations

  1. Xintela AB, Medicon Village, SE-223 81, Lund, Sweden

    Evy Lundgren-Åkerlund

  2. Department of Surgery, Ludwig-Maximilians-University, Nussbaumstr. 20, 80336, Munich, Germany

    Attila Aszòdi

Authors
  1. Evy Lundgren-Åkerlund
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  2. Attila Aszòdi
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Corresponding author

Correspondence to Evy Lundgren-Åkerlund .

Editor information

Editors and Affiliations

  1. University of Bergen, Bergen, Norway

    Donald Gullberg

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Lundgren-Åkerlund, E., Aszòdi, A. (2014). Integrin α10β1: A Collagen Receptor Critical in Skeletal Development. In: Gullberg, D. (eds) I Domain Integrins. Advances in Experimental Medicine and Biology, vol 819. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9153-3_4

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