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Relevance of Mitochondrial Functions and Plasticity in Tumor Biology

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Mitochondria: The Anti- cancer Target for the Third Millennium

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Abstract

In this chapter we discuss the relevance of mitochondrial functions and plasticity in tumor biology. In 1920, Otto Warburg first hypothesized that mitochondrial impairment is a leading cause of cancer although he recognized the existence of oxidative tumors. Likewise, Weinhouse (1951) and others found that deficient mitochondrial respiration is not an obligatory feature of cancer and Peter Vaupel suggested in the 90s that tumor oxygenation rather than OXPHOS capacity was the limiting factor of mitochondrial energy production in cancer. Recent studies now clearly indicate that mitochondria are highly functional in mice tumors and the field of oncobioenergetics identified MYC, Oct1 and RAS as pro-OXPHOS oncogenes. In addition, cancer cells adaptation to aglycemia, metabolic symbiosis between hypoxic and non-hypoxic tumor regions as well the reverse Warburg hypothesis support the crucial role of mitochondrial plasticity in the survival of a subclass of tumors. Therefore, mitochondria are now considered as potential targets for anti-cancer therapy and tentative strategies including a bioenergetic profile characterization of the tumor and the subsequent adapted bioenergetic modulation could be considered for cancer killing.

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Acknowledgments

We thank the French National Institute for Scientific and Medical Research (INSERM), Université Victor Segalen Bordeaux 2, Région Aquitaine, Ammi, and Cancéropôle Grand Sud-Ouest for financial support. N. Bellance was supported by a Grant from AFM.

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Authors and Affiliations

  1. Laboratoire “MRGM” (Maladies Rares: Génétique et Métabolisme), Université Bordeaux 2 et Hôpital de Bordeaux, Bordeaux, France

    Emilie Obre, Nadège Bellance, Caroline Jose, Giovanni Benard, Karine Nouette-Gaulain & Rodrigue Rossignol

  2. EA4576 MRGM, Université Bordeaux Segalen, CHU Pellegrin, Place Amélie Raba-Léon, Ecole des Sages Femmes, étage 2, Bordeaux, France

    Rodrigue Rossignol

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  1. Emilie Obre
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  2. Nadège Bellance
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  3. Caroline Jose
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  4. Giovanni Benard
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  5. Karine Nouette-Gaulain
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  6. Rodrigue Rossignol
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Correspondence to Rodrigue Rossignol .

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  1. School of Medical Science, Griffith University, Southport, Queensland, Australia

    Jiri Neuzil

  2. School of Medicine, National University of Singapore, Singapore, Singapore

    Shazib Pervaiz

  3. Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany

    Simone Fulda

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Obre, E., Bellance, N., Jose, C., Benard, G., Nouette-Gaulain, K., Rossignol, R. (2014). Relevance of Mitochondrial Functions and Plasticity in Tumor Biology. In: Neuzil, J., Pervaiz, S., Fulda, S. (eds) Mitochondria: The Anti- cancer Target for the Third Millennium. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8984-4_11

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